In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 16, No. 8 ( 2022-8-4), p. e0010623-
Abstract:
Countermeasures against Zika virus (ZIKV), including vaccines, are frequently tested in nonhuman primates (NHP). Macaque models are important for understanding how ZIKV infections impact human pregnancy due to similarities in placental development. The lack of consistent adverse pregnancy outcomes in ZIKV-affected pregnancies poses a challenge in macaque studies where group sizes are often small (4–8 animals). Studies in small animal models suggest that African-lineage Zika viruses can cause more frequent and severe fetal outcomes. No adverse outcomes were observed in macaques exposed to 1x10 4 PFU (low dose) of African-lineage ZIKV at gestational day (GD) 45. Here, we exposed eight pregnant rhesus macaques to 1x10 8 PFU (high dose) of African-lineage ZIKV at GD 45 to test the hypothesis that adverse pregnancy outcomes are dose-dependent. Three of eight pregnancies ended prematurely with fetal death. ZIKV was detected in both fetal and placental tissues from all cases of early fetal loss. Further refinements of this exposure system (e.g., varying the dose and timing of infection) could lead to an even more consistent, unambiguous fetal loss phenotype for assessing ZIKV countermeasures in pregnancy. These data demonstrate that high-dose exposure to African-lineage ZIKV causes pregnancy loss in macaques and also suggest that ZIKV-induced first trimester pregnancy loss could be strain-specific.
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0010623
DOI:
10.1371/journal.pntd.0010623.g001
DOI:
10.1371/journal.pntd.0010623.g002
DOI:
10.1371/journal.pntd.0010623.g003
DOI:
10.1371/journal.pntd.0010623.g004
DOI:
10.1371/journal.pntd.0010623.g005
DOI:
10.1371/journal.pntd.0010623.g006
DOI:
10.1371/journal.pntd.0010623.g007
DOI:
10.1371/journal.pntd.0010623.t001
DOI:
10.1371/journal.pntd.0010623.t002
DOI:
10.1371/journal.pntd.0010623.s001
DOI:
10.1371/journal.pntd.0010623.s002
DOI:
10.1371/journal.pntd.0010623.s003
DOI:
10.1371/journal.pntd.0010623.s004
DOI:
10.1371/journal.pntd.0010623.s005
DOI:
10.1371/journal.pntd.0010623.s006
DOI:
10.1371/journal.pntd.0010623.s007
DOI:
10.1371/journal.pntd.0010623.s008
DOI:
10.1371/journal.pntd.0010623.s009
DOI:
10.1371/journal.pntd.0010623.s010
DOI:
10.1371/journal.pntd.0010623.s011
DOI:
10.1371/journal.pntd.0010623.s012
DOI:
10.1371/journal.pntd.0010623.s013
DOI:
10.1371/journal.pntd.0010623.s014
DOI:
10.1371/journal.pntd.0010623.s015
DOI:
10.1371/journal.pntd.0010623.s016
DOI:
10.1371/journal.pntd.0010623.s017
DOI:
10.1371/journal.pntd.0010623.s018
DOI:
10.1371/journal.pntd.0010623.s019
DOI:
10.1371/journal.pntd.0010623.s020
DOI:
10.1371/journal.pntd.0010623.s021
DOI:
10.1371/journal.pntd.0010623.s022
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2429704-5
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