In:
Journal of Complementary and Integrative Medicine, Walter de Gruyter GmbH, Vol. 19, No. 2 ( 2022-09-21), p. 467-470
Abstract:
A mixture of Z and E communic acid is isolated for the first time from the cones of Juniperus phoenicea. Its biological activity was studied. Methods The plant material was extracted in a Soxhlet apparatus with n -hexane, the resulting extract was subjected to column chromatography (CC) on silica gel. The structure elucidation of the constituents of the isolated fraction was identified by comparison of its spectroscopic properties 1 H and 13 C NMR data with those reported in the literature. The antimicrobial assay of hexanic extract and isolated compounds was carried out by the disc diffusion and micro-dilution methods. Results A mixture of two diterpene acids isomers was isolated, with a high yield (68%). Their chemical structures were confirmed after comparing their spectral data with published reports. These natural products exhibited a significant antibacterial and antifungal activity against the tested strains. Indeed, for Bacillus cereus , Staphylococcus aureus , and Pseudomonas aeruginosa , the inhibition zone diameters (36–37 mm) was better than penicillin, novobiocin, and amoxicillin. For Candida albican s activity, it show that the mixture possess an activity similar to that of Metrazol. Against Escherichia coli , the inhibitory activity was found less than Amoxicillin. This is the first report of isolation of communic acid from J. phoenicea . Conclusions These results showed that the cones of J. phoenicea were an important source of communic acid, and its hexanic extract had the greatest potential antibacterial activity against both Gram-negative and Gram-positive bacteria and C. albicans .
Type of Medium:
Online Resource
ISSN:
2194-6329
,
1553-3840
DOI:
10.1515/jcim-2019-0319
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2022
detail.hit.zdb_id:
2197618-1
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