In:
Alzheimer's & Dementia, Wiley, Vol. 17, No. S4 ( 2021-12)
Abstract:
Here, we investigated the contribution of education and regional amyloid as potential de‐ and accelerators in the spread of tau pathology. Method 85 amyloid‐positive subjects (age=76.80±1.08, education=16.70 ±.50 years, M/F=42/43) were included, for whom [18F]AV‐1451 PET at two timepoints, baseline [18F] AV‐45 PET, ApoE‐status and clinical information were available at ADNI. [18F]AV‐1451 PETs were intensity‐standardized (reference: inferior cerebellum) and z‐transformed (control sample: 35 amyloid‐negative subjects). Baseline and follow‐up tau‐PET z‐maps were converted to volume‐maps (z‐score threshold 〉 1.96). Based on these volume‐maps, tau‐changes over time were assessed: 1) tau speed (i.e. newly affected volume at follow‐up), 2) tau level rise (i.e. tau increase in previously affected volume). These two dependent variables were used in regression analyses including education, global amyloid, baseline tau, ApoE, cognitive function, sex, and age as predictors. Additionally, baseline amyloid‐burden was regionally correlated in 32 Freesurfer‐ROIs with newly tau‐affected volume and with mean z‐score change in five Meta‐ROIs (entorhinal cortex, inferior‐temporal, precuneus, middle‐occipital, oribito‐frontal), correcting for multiple comparisons. Result Education contributed as decelerator ( β=‐.322, p=.037 ), whereas global amyloid ( β=.262, p=.029 ) and baseline tau ( β=.283, p=.028 ) facilitated tau speed. Tau level rise was positively associated with age ( β=‐.211, p=.017 ) and baseline tau ( β=.710, p 〈 .001 ). Tau spread to the precuneus was related with greater cingulate amyloid‐burden, whereas tau level rise in temporal, parietal and occipital regions was associated with orbito‐frontal and cingulate amyloid‐burden. Conclusion A combination of de‐ and accelerating factors and regional dissociations likely contribute to the temporo‐spatial evolution of tau pathology.
Type of Medium:
Online Resource
ISSN:
1552-5260
,
1552-5279
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
2201940-6
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