In:
Journal of Thyroid Research, Hindawi Limited, Vol. 2020 ( 2020-05-05), p. 1-8
Abstract:
Purpose . The primary aim of this study was to determine the incidence of estrogen receptor α (ER α ), estrogen receptor β (ER β ), and human epidermal growth factor receptor 2 (HER-2) expression in various subtypes of thyroid carcinoma (TC) of follicular origin and the secondary aim was to correlate the expression with various clinicopathologic prognostic factors. Methods . Immunohistochemistry analysis was performed on archival paraffin-embedded tissue sections (1991–2016). ER α , ER β, and HER-2 expressions were correlated with clinicopathologic prognostic factors, disease recurrence, and overall survival (OS). Results . A total of 264 TC patients were included in the study. Incidences of ER α , ER β, and HER-2 were 8.1 vs 16.3 vs 13.9% p = 0.15 , 26.6 vs 11.5 vs 36.1% p = 0.002 , and 12.9 vs 2.9 vs 0% p = 0.003 in papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC), and poorly differentiated thyroid carcinoma (PDTC), respectively. Overall ER α had significant correlation with distant metastases (0.038) and in case of PDTC with multicentricity p = 0.037 . ER β had significant correlation with lymph node metastases p = 0.023 in FTC. HER-2 correlated with tumor size p = 0.027 only on univariate analysis. OS did not correlate with expression of any receptor. Conclusion . ER α , ER β, and HER-2 have differential expression and prognostic implications in different TC subtypes.
Type of Medium:
Online Resource
ISSN:
2090-8067
,
2042-0072
DOI:
10.1155/2020/6935724
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2020
detail.hit.zdb_id:
2549014-X
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