In:
Brain Imaging and Behavior, Springer Science and Business Media LLC, Vol. 17, No. 2 ( 2023-04), p. 257-269
Abstract:
Social and non-social deficits in autism spectrum disorders (ASD) persist into adulthood and may share common regions of aberrant neural activations. The current meta-analysis investigated activation differences between ASD and neurotypical controls irrespective of task type. Activation likelihood estimation meta-analyses were performed to examine consistent hypo-activated and/or hyper-activated regions for all tasks combined, and for social and non-social tasks separately; meta-analytic connectivity modelling and behavioral/paradigm analyses were performed to examine co-activated regions and associated behaviors. One hundred studies (mean age range = 18–41 years) were included. For all tasks combined, the ASD group showed significant (p 〈 .05) hypo-activation in one cluster around the left amygdala (peak − 26, -2, -20, volume = 1336 mm 3 , maximum ALE = 0.0327), and this cluster co-activated with two other clusters around the right cerebellum (peak 42, -56, -22, volume = 2560mm 3 , maximum ALE = 0.049) Lobule VI/Crus I and the left fusiform gyrus (BA47) (peak − 42, -46, -18, volume = 1616 mm 3 , maximum ALE = 0.046) and left cerebellum (peak − 42, -58, -20, volume = 1616mm 3 , maximum ALE = 0.033) Lobule VI/Crus I. While the left amygdala was associated with negative emotion (fear) (z = 3.047), the left fusiform gyrus/cerebellum Lobule VI/Crus I cluster was associated with language semantics (z = 3.724) and action observation (z = 3.077). These findings highlight the left amygdala as a region consistently hypo-activated in ASD and suggest the potential involvement of fusiform gyrus and cerebellum in social cognition in ASD. Future research should further elucidate if and how amygdala-fusiform/cerebellar connectivity relates to social and non-social cognition in adults with ASD.
Type of Medium:
Online Resource
ISSN:
1931-7557
,
1931-7565
DOI:
10.1007/s11682-022-00754-2
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2023
detail.hit.zdb_id:
2377165-3
SSG:
5,2
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