In:
Current Organic Chemistry, Bentham Science Publishers Ltd., Vol. 26, No. 20 ( 2023-10), p. 1827-1847
Abstract:
In this review, we have focused our attention on Pd-catalyzed amination and arylation
reactions for the construction of various benzodiazepine scaffolds. It includes numerous types of synthetic strategies like C-H arylation, Pd-catalyzed carbonylation, and Buchwald
Hartwig coupling. To synthesize different functionalized benzodiazepines, the domino processes as intra- or intermolecular reactions are developed as an eco-friendly and effective tool.
Benzodiazepines exhibit several biological activities and play a valuable role in medicinal and pharmaceutical chemistry. This review article mainly focuses on synthesizing a 1,4-
benzodiazepine nucleus fused with 5-membered carbo- and heterocycles in the presence of palladium catalysts.
Type of Medium:
Online Resource
ISSN:
1385-2728
DOI:
10.2174/1385272827666221229104724
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2023
Permalink