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  • 1
    Online Resource
    Online Resource
    Contemporary Management of Severe Symptomatic Aortic Stenosis
    Elsevier BV ; 2021
    In:  Journal of the American College of Cardiology Vol. 78, No. 22 ( 2021-11), p. 2131-2143
    Details
    In: Journal of the American College of Cardiology, Elsevier BV, Vol. 78, No. 22 ( 2021-11), p. 2131-2143
    Type of Medium: Online Resource
    ISSN: 0735-1097
    URL: Article
    DOI: 10.1016/j.jacc.2021.09.864
    RVK:
    XA 17760
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 1468327-1
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  • 2
    Online Resource
    Online Resource
    Perception–Action Integration Is Altered in Functional Movement Disorders
    Wiley ; 2023
    In:  Movement Disorders Vol. 38, No. 8 ( 2023-08), p. 1399-1409
    Details
    In: Movement Disorders, Wiley, Vol. 38, No. 8 ( 2023-08), p. 1399-1409
    Abstract: Although functional neurological movement disorders (FMD) are characterized by motor symptoms, sensory processing has also been shown to be disturbed. However, how the integration of perception and motor processes, essential for the control of goal‐directed behavior, is altered in patients with FMD is less clear. A detailed investigation of these processes is crucial to foster a better understanding of the pathophysiology of FMD and can systematically be achieved in the framework of the theory of event coding (TEC). Objective The aim was to investigate perception–action integration processes on a behavioral and neurophysiological level in patients with FMD. Methods A total of 21 patients and 21 controls were investigated with a TEC‐related task, including concomitant electroencephalogram (EEG) recording. We focused on EEG correlates established to reflect perception–action integration processes. Temporal decomposition allowed to distinguish between EEG codes reflecting sensory (S‐cluster), motor (R‐cluster), and integrated sensory–motor processing (C‐cluster). We also applied source localization analyses. Results Behaviorally, patients revealed stronger binding between perception and action, as evidenced by difficulties in reconfiguring previously established stimulus–response associations. Such hyperbinding was paralleled by a modulation of neuronal activity clusters, including reduced C‐cluster modulations of the inferior parietal cortex and altered R‐cluster modulations in the inferior frontal gyrus. Correlations of these modulations with symptom severity were also evident. Conclusions Our study shows that FMD is characterized by altered integration of sensory information with motor processes. Relations between clinical severity and both behavioral performance and neurophysiological abnormalities indicate that perception–action integration processes are central and a promising concept for the understanding of FMD. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
    Type of Medium: Online Resource
    ISSN: 0885-3185 , 1531-8257
    URL: Issue
    URL: Article
    DOI: 10.1002/mds.v38.8
    DOI: 10.1002/mds.29458
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2041249-6
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  • 3
    Online Resource
    Online Resource
    Processing of embedded response plans is modulated by an interplay of frontoparietal theta and beta activity
    American Physiological Society ; 2022
    In:  Journal of Neurophysiology Vol. 128, No. 3 ( 2022-09-01), p. 543-555
    Details
    In: Journal of Neurophysiology, American Physiological Society, Vol. 128, No. 3 ( 2022-09-01), p. 543-555
    Abstract: Even simple actions like opening a door require integration/binding and flexible reactivation of different motor elements. Yet, the neural mechanisms underlying the processing of such “embedded response plans” are largely elusive, despite theoretical frameworks, such as the theory of event coding, describing the involved cognitive processes. In a sample of n = 40 healthy participants, we combine time-frequency decomposition and various beamforming methods to examine the neurophysiological dynamics of such action plans, with special emphasis on the interplay of theta and beta frequency activity during the processing of these plans. We show that the integration and rule-guided reactivation of embedded response plans is modulated by a complex interplay of theta and beta activity. Pretrial beta-band activity (BBA) is related to different functional neuroanatomical structures that are activated in a consecutive fashion. Enhanced preparatory activity is positively associated with higher binding-related BBA in the precuneus/parietal areas, indicating that activity in the precuneus/parietal cortex facilitates the execution of an embedded action sequence. Increased preparation subsequently leads to reduced working memory retrieval demands. A cascading pattern of interactions between pretrial and within-trial activity indicates the importance of preparatory brain activity. The study shows that there are multiple roles of beta and theta oscillations associated with different functional neuroanatomical structures during the integration and reactivation of motor elements during actions. NEW & NOTEWORTHY Even simple actions like opening a door require integration/binding and flexible reactivation of different motor elements. Yet, the neural mechanisms underlying the processing of such “embedded response plans” are largely elusive. The study shows that there are multiple roles of beta and theta oscillations associated with different functional neuroanatomical structures during the integration and reactivation of motor elements during actions.
    Type of Medium: Online Resource
    ISSN: 0022-3077 , 1522-1598
    URL: Article
    DOI: 10.1152/jn.00537.2021
    RVK:
    XA 10000 ; XA 552555
    Language: English
    Publisher: American Physiological Society
    Publication Date: 2022
    detail.hit.zdb_id: 80161-6
    detail.hit.zdb_id: 1467889-5
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  • 4
    Online Resource
    Online Resource
    Investigation of the influence of melt-impregnation parameters on the morphology of thermoplastic UD-tapes and a method for quantifying the same
    SAGE Publications ; 2021
    In:  Journal of Thermoplastic Composite Materials Vol. 34, No. 9 ( 2021-09), p. 1299-1312
    Details
    In: Journal of Thermoplastic Composite Materials, SAGE Publications, Vol. 34, No. 9 ( 2021-09), p. 1299-1312
    Abstract: During the production of unidirectional fibre-reinforced thermoplastic semi-finished products (UD-tapes) in melt-impregnation processes, parameters such as melt viscosity, production speed and impregnation die setup have a significant influence on the quality of the produced UD-tapes. These influences are investigated in this article by producing UD-tapes in an extrusion-based melt-impregnation process with varying impregnation parameters. To quantify the homogeneity of the fibre distribution, a method is presented and applied, in which microscopic cross-sectional images of the UD-tapes are analysed and a homogeneity coefficient is calculated. The porosity is also determined by analysing microscopic cross-sectional images of the UD-tapes. The results show that a decreased melt viscosity and a high number of redirection elements in the die have a positive influence on the homogeneity of the fibre distribution. Furthermore, a significant influence of the melt viscosity, the production speed and the die setup on the porosity was proved.
    Type of Medium: Online Resource
    ISSN: 0892-7057 , 1530-7980
    URL: Article
    DOI: 10.1177/0892705719864624
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2098671-3
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  • 5
    Online Resource
    Online Resource
    Perception‐action integration during inhibitory control is reflected in a concomitant multi‐region processing of specific codes in the neurophysiological signal
    Wiley ; 2023
    In:  Psychophysiology Vol. 60, No. 2 ( 2023-02)
    Details
    In: Psychophysiology, Wiley, Vol. 60, No. 2 ( 2023-02)
    Abstract: The integration of perception and action has long been studied in psychological science using overarching cognitive frameworks. Despite these being very successful in explaining perception‐action integration, little is known about its neurophysiological and especially the functional neuroanatomical foundations. We show that perception‐action integration reflects a multi‐region processing of specific fractions of information in the neural signal. This needs to be taken into account when further developing a cognitive science framework detailing perception‐action integration.
    Type of Medium: Online Resource
    ISSN: 0048-5772 , 1469-8986
    URL: Issue
    URL: Article
    DOI: 10.1111/psyp.v60.2
    DOI: 10.1111/psyp.14178
    RVK:
    CL 1000
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1484299-3
    SSG: 5,2
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  • 6
    Online Resource
    Online Resource
    Predictability reduces event file retrieval
    Springer Science and Business Media LLC ; 2023
    In:  Attention, Perception, & Psychophysics Vol. 85, No. 4 ( 2023-05), p. 1073-1087
    Details
    In: Attention, Perception, & Psychophysics, Springer Science and Business Media LLC, Vol. 85, No. 4 ( 2023-05), p. 1073-1087
    Abstract: There is growing consensus that stimulus–response bindings (event files) play a central role in human action control. Here, we investigated how the integration and the retrieval of event files are affected by the predictability of stimulus components of event files. We used the distractor–response binding paradigm, in which nominally task-irrelevant distractors are repeated or alternated from a prime to a probe display. The typical outcome of these kinds of tasks is that the effects of distractor repetition and response repetition interact: Performance is worse if the distractor repeats but the response does not, or vice versa. This partial-repetition effect was reduced when the distractor was highly predictable (Experiment 1). Separate manipulations of distractor predictability in the prime and probe trial revealed that this pattern was only replicated if the probe distractors were predictable (Experiment 2b, 3), but not if prime distractors were predictable (Experiment 2a). This suggests that stimulus predictability does not affect the integration of distractor information into event files, but the retrieval of these files when one or more of the integrated features are repeated. We take our findings to support theoretical claims that integration and retrieval of event files might differ concerning their sensitivity to top-down factors.
    Type of Medium: Online Resource
    ISSN: 1943-3921 , 1943-393X
    URL: Article
    DOI: 10.3758/s13414-022-02637-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2480891-X
    SSG: 5,2
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  • 7
    Online Resource
    Online Resource
    Stimulus decay functions in action control
    Springer Science and Business Media LLC ; 2022
    In:  Scientific Reports Vol. 12, No. 1 ( 2022-11-22)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2022-11-22)
    Abstract: When facing particular combinations of stimuli and responses, people create temporary event-files integrating the corresponding stimulus and response features. Subsequent repetition of one or more of these features retrieves the entire event-file, which impairs performance if not all features are repeated (partial-repetition costs). In the literature, different decay functions have been reported presumably dependent on the type of feature that is repeated (e.g. target vs. distractor features). Here, we use a variant of the S1R1-S2R2 and distractor-response binding task and analyze for the first time target-based and distractor-based event-file decay functions within the same task and sample. While we found evidence for decay functions and also stronger retrieval due to target than distractor repetitions, slopes of the decay functions were comparable suggesting that the decay process itself is equal irrespective of the type of stimulus feature that is repeated. Our study thereby confirms overarching approaches that summarize paradigm specific findings with the same set of core processes.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-022-24499-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2615211-3
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  • 8
    Online Resource
    Online Resource
    The Role of the Left Inferior Parietal Cortex in Gilles de la Tourette Syndrome—An rTMS Study
    MDPI AG ; 2023
    In:  Biomedicines Vol. 11, No. 3 ( 2023-03-22), p. 980-
    Details
    In: Biomedicines, MDPI AG, Vol. 11, No. 3 ( 2023-03-22), p. 980-
    Abstract: Increased activity in the left inferior parietal cortex (BA40) plays a role in the generation of tics in the Gilles de la Tourette syndrome (GTS). Thus, inhibitory repetitive transcranial magnetic stimulation (rTMS) applied to BA40 was hypothesized to alleviate symptoms in GTS. We investigated the immediate effects of single-session 1 Hz rTMS and sham stimulation delivered to the left BA40 on tics assessed with the Rush video protocol in 29 adults with GTS. There were no significant effects on tic symptoms following rTMS or sham stimulation. Moreover, there was no difference when comparing the effects of both stimulation conditions. Bayesian statistics indicated substantial evidence against an intervention effect. The left BA40 appears not to be a useful target for 1 Hz rTMS to modulate tic symptoms in GTS patients.
    Type of Medium: Online Resource
    ISSN: 2227-9059
    URL: Article
    DOI: 10.3390/biomedicines11030980
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2720867-9
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  • 9
    Online Resource
    Online Resource
    Cognitive and Neural Mechanisms of Behavior Therapy for Tics: A Perception–Action Integration Approach
    MDPI AG ; 2023
    In:  Biomedicines Vol. 11, No. 6 ( 2023-05-26), p. 1550-
    Details
    In: Biomedicines, MDPI AG, Vol. 11, No. 6 ( 2023-05-26), p. 1550-
    Abstract: European clinical guidelines recommend the use of Exposure and Response Prevention (ERP) and Comprehensive Behavioral Intervention for Tics (CBIT) as first-line treatments for tic disorders. Although ongoing efforts in research are being made to understand the mechanisms underlying these behavioral approaches, as of yet, the neurophysiological mechanisms behind behavioral interventions are poorly understood. However, this is essential to tailor interventions to individual patients in order to increase compliance and efficacy. The Theory of Event Coding (TEC) and its derivative BRAC (Binding and Retrieval in Action Control) provide a theoretical framework to investigate cognitive and neural processes in the context of tic disorders. In this context, tics are conceptualized as a phenomenon of enhanced perception–action binding, with premonitory urges constituting the perceptual and the motor or vocal expression constituting the action part of an event file. Based on this, CBIT is assumed to strongly affect stimulus–response binding in the context of response selection, whereas the effects of ERP presumably unfold during stimulus–response binding in the response inhibition context. Further studies are needed to clarify the neurophysiological processes underlying behavioral interventions to enable the individualization and further development of therapeutic approaches for tic disorders.
    Type of Medium: Online Resource
    ISSN: 2227-9059
    URL: Article
    DOI: 10.3390/biomedicines11061550
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2720867-9
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  • 10
    Online Resource
    Online Resource
    Interplay between alpha and theta band activity enables management of perception-action representations for goal-directed behavior
    Springer Science and Business Media LLC ; 2023
    In:  Communications Biology Vol. 6, No. 1 ( 2023-05-06)
    Details
    In: Communications Biology, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2023-05-06)
    Abstract: Goal-directed behavior requires integrated mental representations of perceptions and actions. The neurophysiological underpinnings of these processes, however, are not yet understood. It is particularly undetermined, which oscillatory activities in which brain regions are involved in the management of perception-action representations. We examine this question with a focus on response inhibition processes and show that the dynamics of perception-action representations reflected in theta band activity (TBA) are particularly evident in the supplementary motor area and the occipito-temporal cortex. Mental representations coded in alpha band activity (ABA) during perception-action integration are associated with the occipito-temporal cortex. Crucially, perception-action representations are exchanged between theta and alpha frequency bands. The results imply that ABA functions as dynamic top-down control over binding, retrieval and reconfiguration processes during response inhibition, which in turn are reflected by TBA. Our study thus highlights how the interplay of oscillatory activity enables the management of perception-action representations for goal-directed behavior.
    Type of Medium: Online Resource
    ISSN: 2399-3642
    URL: Article
    DOI: 10.1038/s42003-023-04878-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2919698-X
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