In:
Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 31, No. 15_suppl ( 2013-05-20), p. e20603-e20603
Abstract:
e20603 Background: β-glucans have antibacterial, immunomodulator and anti-cancer effects. The present study aimed to determine the effect of oral β-glucan on mucositis and leukopenia in a group of colorectal cancer patients with a high risk for neutropenia and mucositis who received adjuvant FOLFOX-4 (oxaliplatin, 5-flourouracil, and folinic acid) combination chemotherapy. Methods: This retrospective study included 62 patients with colorectal cancer that underwent a FOLFOX-4 treatment regimen between July 2009 and July 2010. Ethics committee of Erciyes University approved the study design. Colorectal cancer patients treated with a FOLFOX-4 regimen were retrospectively evaluated in 2 equal groups: One group received β-glucan (treatment group), and the other did not (control group). In both groups the level of leucocytes, neutrophils, and platelets were evaluated before and 1 week after chemotherapy. The occurrence of oral mucositis and diarrhea was noted. Data were statistically analyzed. Results: There were 21 male and 10 female patients in the treatment group, and the median age was 61 years (range: 43-72 years). The control group included 17 male and 14 female patients, and the median age was 55 years (range: 30-78 years). There weren't any statistically differences in age or gender between the 2 groups. Leucocyte and neutrophil counts after chemotherapy in the treatment group were 7300/mm 3 and 3800/mm 3 , respectively, and the reductions, as compared to baseline, were not significant (p = 0.673 and 0.784). The median platelet count was 264000/mm 3 after chemotherapy in the treatment group and the reduction, as compared to baseline, was borderline significant (p = 0.048). In the control group the reduction in leucocyte, neutrophil, and platelet counts was statistically significant (median values were 5600/mm 3 , 2880/mm 3 , and 229000/mm 3 , respectively; p 〈 0.01). In addition, oral mucositis and diarrhea secondary to chemotherapy were less common in the treatment group (19% v.s 42%). Conclusions: β-glucan effectively suppressed the adverse effects of chemotherapy. We think that nutritional supplementation with β-glucan in cancer patients should be investigated further.
Type of Medium:
Online Resource
ISSN:
0732-183X
,
1527-7755
DOI:
10.1200/jco.2013.31.15_suppl.e20603
Language:
English
Publisher:
American Society of Clinical Oncology (ASCO)
Publication Date:
2013
detail.hit.zdb_id:
2005181-5
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