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  • 1
    Online Resource
    Online Resource
    Biomechanical stability of novel mechanically adapted open-porous titanium scaffolds in metatarsal bone defects of sheep
    Elsevier BV ; 2015
    In:  Biomaterials Vol. 46 ( 2015-04), p. 35-47
    Details
    In: Biomaterials, Elsevier BV, Vol. 46 ( 2015-04), p. 35-47
    Type of Medium: Online Resource
    ISSN: 0142-9612
    URL: Article
    DOI: 10.1016/j.biomaterials.2014.12.010
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2015
    detail.hit.zdb_id: 2004010-6
    SSG: 12
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  • 2
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    Cartilage regeneration by bone marrow cells-seeded scaffolds
    Wiley ; 2010
    In:  Journal of Biomedical Materials Research Part A Vol. 95A, No. 3 ( 2010-12-01), p. 735-740
    Details
    In: Journal of Biomedical Materials Research Part A, Wiley, Vol. 95A, No. 3 ( 2010-12-01), p. 735-740
    Type of Medium: Online Resource
    ISSN: 1549-3296
    URL: Issue
    URL: Article
    DOI: 10.1002/jbm.a.v95a:3
    DOI: 10.1002/jbm.a.32885
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 1477192-5
    SSG: 12
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  • 3
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    Impact of Preoperative Function on Early Postoperative Outcome after Total Hip Arthroplasty
    SAGE Publications ; 2010
    In:  Journal of Orthopaedic Surgery Vol. 18, No. 1 ( 2010-04), p. 6-10
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 18, No. 1 ( 2010-04), p. 6-10
    Abstract: To investigate the impact of preoperative functional status on early postoperative outcomes after total hip arthroplasty (THA). Methods. 39 men and 36 women aged 50 to 76 years who underwent cementless THA for osteoarthritis were followed up for at least 2 years. Patients were evaluated pre- and post-operatively (at 6, 12, and 24 months) using the Harris Hip Score (HHS), 36-item Short Form Health Survey (SF-36), and Western Ontario and McMaster University Osteoarthritis Index (WOMAC). Patients were classified into 3 groups based on their preoperative HHS (poor, 〈 45; intermediate, 45–55; good, 〉 55). Differences between and within groups were compared. Results. Patients with a poor preoperative HHS had worse early postoperative outcomes in terms of HHS, SF-36, and WOMAC. Postoperative pain and function correlated with preoperative HHS, but postoperative range of motion and deformity did not. Conclusion. Poor preoperative function may affect recovery unfavourably and lead to prolonged pain. Earlier THA in the course of functional decline may associate with better outcomes.
    Type of Medium: Online Resource
    ISSN: 2309-4990 , 2309-4990
    URL: Article
    DOI: 10.1177/230949901001800102
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2128854-9
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  • 4
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    IL-6-induced response of human osteoblasts from patients with rheumatoid arthritis after inhibition of the signaling pathway
    Springer Science and Business Media LLC ; 2023
    In:  Clinical and Experimental Medicine
    Details
    In: Clinical and Experimental Medicine, Springer Science and Business Media LLC
    Abstract: Interleukin (IL-) 6 is a critical factor in inflammatory processes of rheumatoid arthritis (RA). This is of high interest as the progression of RA may lead to the implantation of joint endoprostheses, which is associated with a pro-inflammatory increase in IL-6 in the periprosthetic tissue. Biological agents such as sarilumab have been developed to inhibit IL-6-mediated signaling. However, IL-6 signaling blockade should consider the inhibition of inflammatory processes and the regenerative functions of IL-6. This in vitro study investigated whether inhibiting IL-6 receptors can affect the differentiation of osteoblasts isolated from patients with RA. Since wear particles can be generated at the articular surfaces of endoprostheses leading to osteolysis and implant loosening, the potential of sarilumab to inhibit wear particle-induced pro-inflammatory processes should be investigated. Both in monocultures and indirect co-cultures with osteoclast-like cells (OLCs), human osteoblasts were stimulated with 50 ng/mL each of IL-6 + sIL-6R and in combination with sarilumab (250 nM) to characterize cell viability and osteogenic differentiation capacity. Furthermore, the influence of IL-6 + sIL-6R or sarilumab on viability, differentiation, and inflammation was evaluated in osteoblasts exposed to particles. Stimulation with IL-6 + sIL-6R and sarilumab did not affect cell viability. Except for the significant induction of RUNX2 mRNA by IL-6 + sIL-6R and a significant reduction with sarilumab, no effects on cell differentiation and mineralization could be detected. Furthermore, the different stimulations did not affect the osteogenic and osteoclastic differentiation of co-cultured cells. Compared to the osteoblastic monocultures, a decreased release of IL-8 was triggered in the co-culture. Among these, treatment with sarilumab alone resulted in the greatest reduction of IL-8. The co-culture also showed clearly increased OPN concentrations than the respective monocultures, with OPN secretion apparently triggered by the OLCs. Particle exposure demonstrated decreased osteogenic differentiation using different treatment strategies. However, sarilumab administration caused a trend toward a decrease in IL-8 production after stimulation with IL-6 + sIL-6R. The blockade of IL-6 and its pathway have no significant effect on the osteogenic and osteoclastic differentiation of bone cells derived from patients with RA. Nonetheless, observed effects on the reduced IL-8 secretion need further investigation.
    Type of Medium: Online Resource
    ISSN: 1591-9528
    URL: Article
    DOI: 10.1007/s10238-023-01103-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2054398-0
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  • 5
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    Patellar Tracking in Total Knee Arthroplasty—Influence on Clinical and Functional Outcome
    MDPI AG ; 2022
    In:  Diagnostics Vol. 12, No. 5 ( 2022-04-26), p. 1082-
    Details
    In: Diagnostics, MDPI AG, Vol. 12, No. 5 ( 2022-04-26), p. 1082-
    Abstract: Anterior knee pain is a common problem after primary total knee arthroplasty (TKA). The aim of this study was to find parameters in patellar positioning which influence the clinical and functional outcome after TKA. Included were 59 patients who underwent TKA, of which three patients were treated bilaterally (n = 62 included knees). In a periodical follow-up of up to 5 years, each patient had to answer three questionnaires (HSS, WOMAC, SF-36) and underwent three radiographies of the knee (including merchant view) and a clinical examination, including Range Of Motion (ROM). All radiographs were evaluated by a single observer blinded to clinical data, who collected multiple parameters of sagittal and axial patellar alignment including newly developed methods for measuring patellar shift and tilt. Depending on the measurement results, three groups were built for each parameter and the influence on the outcome was determined. A lateral patellar tilt of more than 4° resulted in lower scores for both the HSS and WOMAC. The rarely investigated patellar facet angle showed a significantly inferior clinical and functional outcome in late follow-up of 〉 24 months if lower than 142°, possibly due to progressive osteosclerotic changes of the patella caused by increased contact stress with corresponding patellar morphology. No significant difference was found for all other parameters. The newly developed method for measuring patellar shift has proven to be a valuable and easy instrument in the postoperative setting.
    Type of Medium: Online Resource
    ISSN: 2075-4418
    URL: Article
    DOI: 10.3390/diagnostics12051082
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662336-5
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  • 6
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    The effect of a digital-assisted group rehabilitation on clinical and functional outcomes after total hip and knee arthroplasty—a prospective randomized controlled pilot study
    Springer Science and Business Media LLC ; 2023
    In:  BMC Musculoskeletal Disorders Vol. 24, No. 1 ( 2023-03-14)
    Details
    In: BMC Musculoskeletal Disorders, Springer Science and Business Media LLC, Vol. 24, No. 1 ( 2023-03-14)
    Abstract: The rising number of total hip and knee arthroplasties and the decreasing availability of physiotherapists require clinically and economically effective rehabilitation approaches. Therefore, the present pilot study investigated the effect of a novel digital-assisted individualized group rehabilitation program on clinical and functional outcomes after total hip and knee arthroplasty. Methods In this randomized controlled pilot study, 26 patients undergoing total knee or hip replacement were randomly assigned to either the intervention group (IG, novel digital-assisted group therapy) or the control group (CG, standard postoperative physiotherapy currently carried out in Germany). The IG received the novel digital-assisted group therapy twice per week for a six-months period, while the CG received individual outpatient therapy depending on the prescription of the supervising physician. The number of therapy sessions was recorded. Moreover, subjective outcomes (EuroQol-5Dimensions (EQ-5D) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)), functional outcome (30 s sit to stand test and timed up and go test (TUG)), as well as gait parameters were quantified preoperatively as well as at three and six months after surgery. Data were analyzed using an analysis of covariance with baseline-adjustment. Results No patient-reported falls, pain, and hospital readmissions were recorded. On average, the IG received more therapy sessions. The clinical and functional outcomes were mainly not significantly different between groups at three- and six-months follow-up, but medium to large effect sizes for the differences in quality of life (EQ-5D) as well as pain, stiffness, and physical function (WOMAC), and TUG performance were observed in favor of the IG. However, the IG showed a higher variability of gait velocity after total joint replacement. Conclusion The digital-assisted rehabilitation had positive effects on quality of life, pain, stiffness, physical function, and TUG performance. Nevertheless, the therapy concept may be improved by adding exercises focusing on gait performance to reduce gait variability. The results indicate that the digital-assisted therapy concept is effective and safe. Therefore, a consecutive full-scaled randomized controlled clinical trial is recommended. Trial registration This study was retrospectively registered on 14/02/2022 in the German Clinical Trial Register (DRKS00027960).
    Type of Medium: Online Resource
    ISSN: 1471-2474
    URL: Article
    DOI: 10.1186/s12891-023-06270-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2041355-5
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  • 7
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    Coexistent lumbar spine disorders have a crucial impact on the clinical outcome after total hip replacement
    Elsevier BV ; 2015
    In:  Journal of Orthopaedic Science Vol. 20, No. 6 ( 2015-11), p. 1046-1052
    Details
    In: Journal of Orthopaedic Science, Elsevier BV, Vol. 20, No. 6 ( 2015-11), p. 1046-1052
    Type of Medium: Online Resource
    ISSN: 0949-2658
    URL: Article
    DOI: 10.1007/s00776-015-0764-y
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2015
    detail.hit.zdb_id: 1481657-X
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  • 8
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    Prospective multi-centre study on a composite ceramic femoral component in total knee arthroplasty: Five-year clinical and radiological outcomes
    Elsevier BV ; 2015
    In:  The Knee Vol. 22, No. 3 ( 2015-06), p. 186-191
    Details
    In: The Knee, Elsevier BV, Vol. 22, No. 3 ( 2015-06), p. 186-191
    Type of Medium: Online Resource
    ISSN: 0968-0160
    URL: Article
    DOI: 10.1016/j.knee.2015.02.003
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2015
    detail.hit.zdb_id: 2008020-7
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  • 9
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    Kramer and Chevron Osteotomy for Hallux Valgus Deformity – Retrospective Comparison of Functional and Radiological Results
    Georg Thieme Verlag KG ; 2019
    In:  Zeitschrift für Orthopädie und Unfallchirurgie Vol. 157, No. 01 ( 2019-02), p. 29-34
    Details
    In: Zeitschrift für Orthopädie und Unfallchirurgie, Georg Thieme Verlag KG, Vol. 157, No. 01 ( 2019-02), p. 29-34
    Abstract: Background Hallux valgus is the most common forefoot deformity, with a prevalence of up to 23%. Surgical treatment is necessary in symptomatic patients. Prospective studies comparing different procedures are rare. Chevron osteotomy is the preferred procedure for distal osteotomy. The relevance of Kramer osteotomy is not clearly defined. The objective of this study was to compare the two procedures in terms of functional and radiological outcome. Material and Methods 174 patients (42 male, 132 female, 44.0 ± 16.8 years), treated with Chevron (n = 71) or Kramer osteotomy (n = 103) between 2008 and 2015, were enrolled in this retrospective study. Time for surgery was analysed. Pre- and postoperative X-rays were evaluated to detect hallux valgus angle, intermetatarsal angle and position of sesamoids (mean ± SD). Function and quality of life were assessed using the Foot and Ankle Outcome Score (FAOS) and EuroQol5D questionnaire. Pain was rated by using the numeric rating scale (NRS). Statistical analyses were performed with mixed model ANOVA and the t test for independent samples. Results Both procedures reduce the hallux valgus angle (Kramer: 30° to 9°; Chevron 26° to 16°; p  〈  0.001). A significant difference was found between the two procedures (10° ± 2°; 95% CI: − 12.93; − 6.49; p  〈  0.001). A minimally reduced intermetatarsal angle was found in both groups (14° ± 3° to 12° ± 3°; p  〈  0.001). However, there was no significant difference between the two procedures (p = 0.116). The position of sesamoids was more improved by Kramer osteotomy (2/2 to 0/1; p  〈  0.001) according to Appel than with the Chevron osteotomy (2/2 to 2/1; p = 0.052). Time for surgery was significantly shorter when Kramer osteotomy was performed (31 ± 14 min vs. 44 ± 12 min; p  〈  0.001). No relevant differences in pain and function were observed (NRS postoperative Chevron: 1.3; Kramer: 1.7; p = 0.413; FAOS: no significant differences in all categories). Conclusion The results of the two procedures were equal in functional outcome. Time of surgery and radiological results were significantly better in the group with Kramer osteotomy. Therefore, Kramer osteotomy is an alternative option to Chevron osteotomy. Further prospective studies are necessary to confirm these results.
    Type of Medium: Online Resource
    ISSN: 1864-6697 , 1864-6743
    URL: Article
    DOI: 10.1055/a-0631-4924
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2019
    detail.hit.zdb_id: 2280747-0
    detail.hit.zdb_id: 2304338-6
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  • 10
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    Comparison of Cross-Sections of Different Femoral Components for Revision Total Knee Replacement
    SAGE Publications ; 2012
    In:  Journal of Orthopaedic Surgery Vol. 20, No. 1 ( 2012-04), p. 32-36
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 20, No. 1 ( 2012-04), p. 32-36
    Abstract: To compare the inner contour of the femoral component of 10 total knee replacement (TKR) designs for possible exchange in use. Methods. Inner contours of the femoral components of 10 cemented, cruciate-retaining TKR designs (e.motion, Genesis, Genia, Innex, LCS, Multigen Plus, NexGen, PFC, Scorpio, Vanguard) were scanned and reconstructed to 2-dimensional contours. Their cross-sections were compared by superimposition and aligning at the distal and anterior cuts. The patellar notch and outer contour were not analysed. Results. The maximum deviation was 5 mm in the posterior and posterior oblique cuts and 10 mm in the anterior oblique cut. Based on similarity of the inner contour, LCS and Innex was classified as group I, e.motion, Genesis, Scorpio, Vanguard, and Multigen Plus as group II, and Genia, NexGen, and PFC as group III. All 2 designs in group I were not compatible with the other 8 designs. Four of the 5 designs in group II showed good compatibility. All 3 designs in group III significantly differed in the posterior and oblique cuts. Conclusion. A standardised inner contour of the femoral component can increase compatibility of different TKR systems in revision surgery and reduces the extent of bone resection.
    Type of Medium: Online Resource
    ISSN: 2309-4990 , 2309-4990
    URL: Article
    DOI: 10.1177/230949901202000107
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2128854-9
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