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  • 1
    Online Resource
    Online Resource
    The pathomorphology of urolithiasis and the chemical analysis of the stones by x-ray diffraction and infrared spectroscopy
    Bionika Media Innovations ; 2021
    In:  Urologiia Vol. 6_2021 ( 2021-12-30), p. 30-34
    Details
    In: Urologiia, Bionika Media Innovations, Vol. 6_2021 ( 2021-12-30), p. 30-34
    Type of Medium: Online Resource
    ISSN: 1728-2985
    Uniform Title: Патоморфология мочекаменной болезни и анализ камней методом рентгеноструктурного анализа и инфракрасной спектроскопии
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.18565/urology.2021.6
    DOI: 10.18565/urology
    DOI: 10.18565/urology.2021.6.30-34
    Language: Russian
    Publisher: Bionika Media Innovations
    Publication Date: 2021
    detail.hit.zdb_id: 43204-0
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  • 2
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    Migration Intent of Health Care Workers during the COVID-19 Pandemic in Kosovo
    MDPI AG ; 2022
    In:  International Journal of Environmental Research and Public Health Vol. 19, No. 17 ( 2022-09-05), p. 11122-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 19, No. 17 ( 2022-09-05), p. 11122-
    Abstract: The migration of healthcare workers from developing countries to more economically developed countries is a long-standing and ongoing trend. Loss of qualified staff due to migration can negatively impact healthcare systems. Understanding factors that drive migration is essential to identifying and managing health system needs. Our study explored factors related to the migration intent of healthcare staff in Kosovo, particularly after the COVID-19 pandemic. We carried out a cross-sectional survey of healthcare workers from public and private institutions. The survey analysed the prevalence of willingness to migrate and whether willingness was affected by the pandemic, and calculated crude and adjusted odds ratios for variables which may influence migration willingness. 14.43% of healthcare workers reported aspiration to migrate, and 23.68% reported an increased chance of migrating after the pandemic. Dissatisfaction with wages and working conditions, higher education and private sector engagement were associated with increased odds of migration willingness. After the pandemic, factors related to interpersonal relationships and state response gave lower odds of migration intent. These findings point to potential factors associated with the migration of healthcare workers, which can help policymakers address gaps in national health system strategy.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph191711122
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2175195-X
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  • 3
    Online Resource
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    ACTES 2018 - Abstracts Book
    Albanian Society for Trauma and Emergency Surgery ; 2018
    In:  Albanian Journal of Trauma and Emergency Surgery Vol. 2, No. 2.2 ( 2018-11-10), p. 1-150
    Details
    In: Albanian Journal of Trauma and Emergency Surgery, Albanian Society for Trauma and Emergency Surgery, Vol. 2, No. 2.2 ( 2018-11-10), p. 1-150
    Abstract: Introduction: although the term “polytrauma” has been in use for decades, no generally accepted definition exists. Our definition has been until 2010: a combination of injuries where one, or the combination where one, or the combination of injuries himself is directly life threatening, in detail is meant: injury to two body cavities, or injury to one cavity committed by two long bone fractures, where spine and unstable pelvis has counted similarly as an injury to a cavity organ. Since 2013 a new definition has been established, the so-called Berlin definition. "A polytrauma means significant injuries of three or more points (AIS) in two or more different anatomic AIS regions in conjunction with one or more additional variables from 5 physiologic parameters: Hypotension (SBP - Systolic Blood Pressure 〈 = 90 mm Hg); Level of consciousness (GCS - Glasgow Coma Scale) ≤ 8; Acidosis (BE - Base Excess ≤ - 5.0); Coagulopathy (INR - International Normalized Ratio ≥ 1.4; PTT - Partial Thromboplastin Time ≥ 40 seconds, and Age ≥ 70 years). This definition fits the reality perfectly. The role of the surgeon in the trauma team is essential. It should provide multidisciplinary care to reduce diagnostic time and optimize therapeutic procedures. As Medicine adapts to the 21st century, new specialties arise. In the management of trauma, two models have been opposed in the past: on one side, a Trauma Surgeon based system, with specialists fully devoted to trauma care, often able to fix skeletal trauma too; on the other hand, blended systems with General Surgeons dealing with both elective and emergency surgery and trauma patients. The evolution of technology, of the epidemiology of trauma, and of the trauma systems and networks entailed the emerging of the concept of Acute Care Surgery. In the vast majority of Countries, this new specialist seems to better fit with the needs of both patients and health organization. Who is the Acute Care Surgeon? What is his minimal educational and technical background? How can interact with the other medical specialists playing around a trauma patient?
    Type of Medium: Online Resource
    ISSN: 2616-4922 , 2521-8778
    URL: Issue
    URL: Article
    DOI: 10.32391/ajtes.v2i2
    DOI: 10.32391/ajtes.v2i2.2.124
    Language: Unknown
    Publisher: Albanian Society for Trauma and Emergency Surgery
    Publication Date: 2018
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  • 4
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    Diabetes and COVID-19: Short- and Long-Term Consequences
    Georg Thieme Verlag KG ; 2022
    In:  Hormone and Metabolic Research Vol. 54, No. 08 ( 2022-08), p. 503-509
    Details
    In: Hormone and Metabolic Research, Georg Thieme Verlag KG, Vol. 54, No. 08 ( 2022-08), p. 503-509
    Abstract: When the corona pandemic commenced more than two years ago, it was quickly recognized that people with metabolic diseases show an augmented risk of severe COVID-19 and an increased mortality compared to people without these comorbidities. Furthermore, an infection with SARS-CoV-2 has been shown to lead to an aggravation of metabolic diseases and in single cases to new-onset metabolic disorders. In addition to the increased risk for people with diabetes in the acute phase of COVID-19, this patient group also seems to be more often affected by long-COVID and to experience more long-term consequences than people without diabetes. The mechanisms behind these discrepancies between people with and without diabetes in relation to COVID-19 are not completely understood yet and will require further research and follow-up studies during the following years. In the current review, we discuss why patients with diabetes have this higher risk of developing severe COVID-19 symptoms not only in the acute phase of the disease but also in relation to long-COVID, vaccine breakthrough infections and re-infections. Furthermore, we discuss the effects of lockdown on glycemic control.
    Type of Medium: Online Resource
    ISSN: 0018-5043 , 1439-4286
    URL: Article
    DOI: 10.1055/a-1878-9566
    RVK:
    XA 46918
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2022
    detail.hit.zdb_id: 2056576-8
    detail.hit.zdb_id: 80125-2
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  • 5
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    Higher COVID-19 Vaccination Rates Are Associated with Lower COVID-19 Mortality: A Global Analysis
    MDPI AG ; 2022
    In:  Vaccines Vol. 11, No. 1 ( 2022-12-28), p. 74-
    Details
    In: Vaccines, MDPI AG, Vol. 11, No. 1 ( 2022-12-28), p. 74-
    Abstract: Mass vaccination initiatives are underway worldwide, and a considerable percentage of the world’s population is now vaccinated. This study examined the association of COVID-19 deaths per 1000 cases with a fully vaccinated population. The global median deaths per 1000 cases were 15.68 (IQR 9.84, 25.87) after 6 months of vaccinations and 11.96 (IQR 6.08, 20.63) after 12 months. Across 164 countries, we found significant variations in vaccination levels of populations, booster doses, and mortality, with higher vaccine coverage and lower mortality in high-income countries. Several regression models were performed to test the association between vaccination and COVID-19 mortality. Control variables were used to account for confounding variables. A 10-percentage-point increase in vaccination was associated with an 18.1% decrease in mortality after 6 months (95%CI, 7.4–28.8%) and a 16.8% decrease after 12 months (95%CI, 6.9–26.7%). A 10-percentage-point increase in booster vaccination rates was associated with a 33.1% decrease in COVID-19 mortality (95%CI, 16.0–50.2%). This relationship is present in most analyses by country income groups with variations in the effect size. Efforts are needed to reduce vaccine hesitancy while ensuring suitable infrastructure and supply to enable all countries to increase their vaccination rates.
    Type of Medium: Online Resource
    ISSN: 2076-393X
    URL: Article
    DOI: 10.3390/vaccines11010074
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2703319-3
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  • 6
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    The interface of COVID-19, diabetes, and depression
    Springer Science and Business Media LLC ; 2022
    In:  Discover Mental Health Vol. 2, No. 1 ( 2022-12)
    Details
    In: Discover Mental Health, Springer Science and Business Media LLC, Vol. 2, No. 1 ( 2022-12)
    Abstract: Comorbid diabetes with depression is a challenging and often under-recognized clinical problem. During the current COVID-19 pandemic, a communicable disease is thriving on the increasing incidences of these non-communicable diseases. These three different health problems are bidirectionally connected forming a vicious cycle. Firstly, depressed individuals show a higher risk of developing diabetes and patients with diabetes have a higher risk of developing symptoms of depression. Secondly, patients with diabetes have a higher risk of developing severe COVID-19 as well as of experiencing breakthrough infections. Thirdly, in both patients with type 2 diabetes and in COVID-19 survivors the prevalence of depression seems to be increased. Fourthly, lockdown and quarantine measurements during the COVID-19 pandemic has led to an increase in depression. Therefore, it is of importance to increase the awareness of this interface between depression, diabetes and COVID-19. Finally, as symptoms of post-COVID, diabetes and depression may be overlapping, there is a need for educating skilled personnel in the management of these comorbidities.
    Type of Medium: Online Resource
    ISSN: 2731-4383
    URL: Article
    DOI: 10.1007/s44192-022-00007-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 3097626-1
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  • 7
    Online Resource
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    The 6th Albanian Congress of Trauma and Emergency Surgery
    Albanian Society for Trauma and Emergency Surgery ; 2022
    In:  Albanian Journal of Trauma and Emergency Surgery Vol. 6, No. 2.6 ( 2022-11-19), p. 1-132
    Details
    In: Albanian Journal of Trauma and Emergency Surgery, Albanian Society for Trauma and Emergency Surgery, Vol. 6, No. 2.6 ( 2022-11-19), p. 1-132
    Abstract: After a three-year quarantine from the deadliest global pandemic of the last century, ASTES is organizing to gather all health professionals in Tirana, The 6th Albanian Congress of Trauma and Emergency Surgery(ACTES 2022) on 11-12 November 2022, with the topic Trauma & Emergency Surgery and not only...with the aim of providing high quality, the best standards, and the best results, for our patients ...ACTES 2022 is the largest event that ASTES (Albanian Society for Trauma and Emergency Surgery) has organized so far with 230 presentations, and 67 foreign lecturers with enviable geography, making it the largest national and wider scientific event.The scientific program is as strong as ever, thanks to the inclusiveness, where all the participants with a mix of foreign and local lecturers, select the best of the moment in medical science, innovation, and observation.The scientific committee has selected all the presentations so that the participants of each medical discipline will have something to learn, discuss, debate, and agree with updated methods, techniques, and protocols.I hope you will join us on Friday morning, and continue the journey of our two-day event together.
    Type of Medium: Online Resource
    ISSN: 2616-4922 , 2521-8778
    URL: Issue
    URL: Article
    DOI: 10.32391/ajtes.v6i2.6
    DOI: 10.32391/ajtes.v6i2.6.307
    Language: Unknown
    Publisher: Albanian Society for Trauma and Emergency Surgery
    Publication Date: 2022
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  • 8
    Online Resource
    Online Resource
    ACTES 2019 - Abstracts Book; The 3rd Albanian Congress of Trauma and Emergency Surgery
    Albanian Society for Trauma and Emergency Surgery ; 2019
    In:  Albanian Journal of Trauma and Emergency Surgery Vol. 3, No. 2.3 ( 2019-11-16), p. 1-124
    Details
    In: Albanian Journal of Trauma and Emergency Surgery, Albanian Society for Trauma and Emergency Surgery, Vol. 3, No. 2.3 ( 2019-11-16), p. 1-124
    Abstract: This event reflects the author's involvement in internationally recognized education and training models, as ATLS, ETC, and DSTC, and  UEMS Boards of Emergency SurgeryDo different countries need very different things? I don’t think so, for the simple reason that in Europe and about the challenges we face, with regard to trauma and other medical and surgical emergencies, similarities are much greater than differences.• We all agree on the need for a trauma system “to assure that patients (…) seamlessly receive the proper care, in the proper locations, with proper interventions and, if necessary, transfer to a hospital able to provide the best and most appropriate care” (www.aast.org).• We all agree that teamwork is necessary for prehospital care, transportation, emergency room care, intensive care, surgery, and in/post-hospital rehabilitation.• We all agree on the need for trauma registries with, as much as possible, global follow-up of patient's course.• And finally, we all agree that it is necessary to educate, how to prevent and how to treat.This is also apparent from the recommendations of the European Trauma Course Organization (ETCO) about equipment and facilities: complete trauma team, trauma admission bay close to the ambulance entrance, enough space and adequate lighting, the adjacent operating room to allow emergency procedures, standardequipment for the initial management of major trauma, immediate availability of additional equipment as difficult airway equipment, X-ray, ultrasound machine, surgical instruments, readily available bloodproducts and massive transfusion equipment, co-located CT scanner to allow immediately imaging and access to angiography and interventional radiology, 24 hours a day within 30-60 minutes of request.
    Type of Medium: Online Resource
    ISSN: 2616-4922 , 2521-8778
    URL: Issue
    URL: Article
    DOI: 10.32391/ajtes.v3i2
    DOI: 10.32391/ajtes.v3i2.3.153
    Language: Unknown
    Publisher: Albanian Society for Trauma and Emergency Surgery
    Publication Date: 2019
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  • 9
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    Metabolic disorders and preventive measures against stones in the urinary tract
    AMALTEA Medical Publishing House ; 2023
    In:  Romanian Journal of Medical Practice Vol. 18, No. 1 ( 2023-03-31), p. 14-19
    Details
    In: Romanian Journal of Medical Practice, AMALTEA Medical Publishing House, Vol. 18, No. 1 ( 2023-03-31), p. 14-19
    Abstract: Introduction. Urolithiasis is not a simple disease, but it is a group of metabolic and endocrine disorders in the organism, coupled with changes in the urinary tract. Objectives. Research on the etiopathogenesis of urolithiasis; to analyze parathyroid hormones, to determine citrates in urine; their influence on the occurrence of urolithiasis. Research and the role of infection in the occurrence of urolithiasis, clinical symptoms, diagnostic methods, prevention methods and as well as preventive measures. Materials and methods. The research was conducted on our patients at the Urology Clinic, University Clinical Center of Kosovo, in Pristina. The work was prospective; in our research, we included 102 patients. Results. Our research has increased Parathormone in 5, 88% of cases. We had hypocitraturia in 57, 84% of cases. Hypocyturia then affects the creation of conditions for the crystallization and aggregation of stoneforming substances. Urolithiasis includes both sexes, primarily men 66, 7%, and women 33.3%. With X2- test we obtained a significant difference with statistical significance in the number of cases by gender (X2 = 11.3, P = 0.001). The most attacked age group was 40-49 years old. Symptoms are dominated by colic, nephralgia, dysuria, and hematuria. In this research, we have 22.5% of positive results of urine cultures. Conclusion. Therefore, there is still no explanation about the pathogenesis of urolithiasis, and with the knowledge of the etiopathogenesis of urolithiasis, symptoms, clinic, metabolic disorders and pathomorphology of urolithiasis, prophylactic measures can be taken, and urolith recurrence can be prevented.
    Type of Medium: Online Resource
    ISSN: 1842-8258 , 2069-6108
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.37897/RJMP.2023.1
    DOI: 10.37897/RJMP
    DOI: 10.37897/RJMP.2023.1.3
    Language: Unknown
    Publisher: AMALTEA Medical Publishing House
    Publication Date: 2023
    detail.hit.zdb_id: 2570962-8
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  • 10
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    Vitamin D-Dimer: A Possible Biomolecule Modulator in Cytotoxic and Phagocytosis Processes?
    MDPI AG ; 2022
    In:  Biomedicines Vol. 10, No. 8 ( 2022-07-25), p. 1785-
    Details
    In: Biomedicines, MDPI AG, Vol. 10, No. 8 ( 2022-07-25), p. 1785-
    Abstract: Background: Vitamin D3 complexed to deglycosylated vitamin D binding protein (VitD-dgVDBP) is a water-soluble vitamin D dimeric compound (VitD-dgVDBP). It is not clear how VitD-dgVDBP affects circulating monocytes, macrophages, other immune cell systems, including phagocytosis and apoptosis, and the generation of reactive oxygen species (ROS) compared to dgVDBP. Methods: Flow cytometry was used to measure superoxide anion radical (O2*−) levels and macrophage activity in the presence of VitD-dgVDBP or dgVDBP. VitD-dgVDBP was incubated with normal human lymphocytes (nPBMCs), and several clusters of determination (CDs) were estimated. dgVDBP and VitD-dgVDBP apoptosis was estimated on malignant prostatic cells. Results: The macrophage activity was 2.8-fold higher using VitD-dgVDBP (19.8·106 counts) compared to dgVDBP (7.0·106 counts), but O2*− production was 1.8-fold lower in favor of VitD-dgVDBP (355·103 counts) compared to dgVDBP (630·106 counts). The calculated ratio of the radical/macrophage activity was 5-fold lower compared to that of dgVDBP. Only VitD-dgVDBP activated caspase-3 (8%), caspase-9 (13%), and cytochrome-C (11%) on prostatic cancer cells. PE-Cy7-labeled VitD-dgVDBP was found to bind to cytotoxic suppressor cells, monocytes/macrophages, dendritic and natural killer cells (CD8+), and helper cells (CD4+). After 12 h of co-incubation of nPBMCs with VitD-dgVDBP, significant activation and expression were measured for CD16++/CD16 (0.6 ± 0.1% vs. 0.4 ± 0.1%, p 〈 0.05), CD45k+ (96.0 ± 6.0% vs. 84.7 ± 9.5%, p 〈 0.05), CD85k+ (24.3 ± 13.2% vs. 3.8 ± 3.2%, p 〈 0.05), and CD85k+/CD123+ (46.8 ± 8.1% vs. 3.5 ± 3.7%, p 〈 0.001) compared to the control experiment. No significant difference was found using CD3+, CD4+, CD8+, CD4/CD8, CD4/CD8, CD16+, CD16++, CD14+, or CD123+. A significant decline in CD14+/CD16+ was obtained in the presence of VitD-dgVDBP (0.7 ± 0.2% vs. 3.1 ± 1.7%; p 〈 0.01). Conclusion: The newly developed water-soluble VitD3 form VitD-dgVDBP affected cytotoxic suppressor cells by activating the low radical-dependent CD16 pathway and seemed to induce apoptosis in malignant prostatic cells.
    Type of Medium: Online Resource
    ISSN: 2227-9059
    URL: Article
    DOI: 10.3390/biomedicines10081785
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2720867-9
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