In:
Drug Metabolism and Bioanalysis Letters, Bentham Science Publishers Ltd., Vol. 16, No. 1 ( 2023-03), p. 14-26
Abstract:
Precision medicine seeks to individualize the dose from the beginning of
pharmacological therapy based on the characteristics of each patient, genes involved in the metabolic phenotype, ethnicity or miscegenation, with the purpose to minimize adverse effects
and optimize drug efficacy. The objective was to review studies that describe the association of the CYP2D6 and CYP2C19 genes with the tricontinental and Latin American ancestry of
Peruvians. A bibliographic search was carried out in PubMed/Medline and SciELO, with various descriptors in Spanish and English. : The results of this review confirm that the ethnic origin of Peruvians is tricontinental due to
European (mainly Spanish), African and Asian migration, in addition to Latin American migration, being 60.2% mixed, 25.8% Amerindian, 5.9% white, 3.6% African descent, 1.2% Chinese and Japanese descent, and 3.3% unspecified. Studies on CYP2C19*3, CYP2D6*2, *3 and *6 have been
reported in Peruvians, and the frequency is similar to that studied in Ecuadorians and Colombians. The CYP2C19*3, CYP2D6*3, and CYP2D6*6 alleles found in Peruvians are common in
Europeans, Africans, and Asians; while CYP2D6*4 in Africans and CYP2D6*2 related to Asians. In some studies, the ethnic/gene association has not been demonstrated; while others have shown
a significant association, which is why further investigation is warranted. It is concluded that the studies on CYP2D6 and CYP2C19 genes associated with the tricontinental and Latin American
ancestry of Peruvians are little, and according to what has been investigated, the CYP2C19*3, CYP2D6*2, *3, *4 and *6 alleles have more related to their ancestry.
Type of Medium:
Online Resource
ISSN:
2949-6810
DOI:
10.2174/1872312815666221213151140
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2023
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