In:
Acta Ophthalmologica, Wiley, Vol. 94, No. 1 ( 2016-02)
Abstract:
To compare the anti‐adhesive effect of cefuroxime and moxifloxacin on the primary attachment phase of Staphylococcus epidermidis on hydrophobic acrylic intraocular lenses ( IOL s). Methods Forty hydrophobic acrylic IOL s were used. Two groups of IOL s were soaked in a moxifloxacin (Mox‐T1: 0.5 mg/0.1 ml) or a cefuroxime (Cef‐T1: cefuroxime 1 mg/0.1 ml) solution before incubation in a S. epidermidis bacterial suspension. Two other groups were incubated in the bacterial suspension before antibiotics (Cef‐T2 and Mox‐T2) were added. The control group (Ctrl) consisted of IOL s incubated in the bacterial suspension. After incubation, IOL s were sonicated and vortexed. The resultant suspension was spread over a nutritive agar plate. Bacterial colonies were counted after 24 hr of incubation. Results Mean number of colony‐forming units per IOL was Cef‐T1 : 184 × 10 3 ( SE : 5.24; SD : 28.21), Cef‐T2 : 117 × 10 3 ( SE : 5.74; SD : 30.37), Mox‐T1 : 1.27 × 10 3 ( SE : 0.12; SD : 0.61), Mox‐T2 : 25 × 10 3 ( SE :1.98; SD : 9.72) and Ctrl : 361 × 10 3 ( SE : 26.9; SD : 107.6). The number of adhering bacteria did not vary whether cefuroxime was added before or after IOL incubation in the bacterial suspension (p = 0.132). Moxifloxacin was more effective in reducing the number of adhering bacteria when used before IOL incubation (p 〈 0.001). Overall for T1 and T2, moxifloxacin was more effective than cefuroxime in reducing bacterial adhesion on IOL s (p 〈 0.001). Conclusion Moxifloxacin and cefuroxime significantly reduced S. epidermidis adhesion on hydrophobic acrylic IOL s. The anti‐adhesive effect was superior with moxifloxacin.
Type of Medium:
Online Resource
ISSN:
1755-375X
,
1755-3768
DOI:
10.1111/aos.2016.94.issue-1
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2466981-7
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