In:
The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 125, No. 4_Supplement ( 2009-04-01), p. 2713-2713
Abstract:
Ultrasound acts synergistically with thrombolytic agents, such as recombinant tissue plasminogen activator (rt-PA), to accelerate thrombolysis. The aim of the study was to demonstrate the efficacy of 120-kHz ultrasound-enhanced rt-PA thrombolysis in a porcine hemorrhagic stroke model in vivo. Clots were formed by infusing 3 ml of autologous blood into the frontal white matter of 30 mixed-bred Yorkshire pigs (20.5–3.1 kg) and incubated for 3 h. For these nonsurvival studies, six pigs received rt-PA alone (0.3 cc of 0.107 mg/ml), six received ultrasound alone, six received rt-PA plus ultrasound, six were sham-exposed (saline only), and six were controls (no ultrasound or rt-PA treatment). The clots receiving ultrasound treatment were insonified with a peak-to-peak pressure of 0.48 MPa in situ (80% duty cycle, and PRF of 1.7 kHz) for 30 min. Clots treated with rt-PA alone exhibited a volume loss of 55.0% and clots treated with rt-PA and 120-kHz ultrasound had a significantly higher volume loss of 75.2% and a higher penetration of rt-PA. Thus, 120-kHz pulsed ultrasound enhancement of thrombolysis has been demonstrated both in vitro and in an in vivo porcine hemorrhagic stroke model.
Type of Medium:
Online Resource
ISSN:
0001-4966
,
1520-8524
Language:
English
Publisher:
Acoustical Society of America (ASA)
Publication Date:
2009
detail.hit.zdb_id:
1461063-2
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