In:
European Journal of Immunology, Wiley, Vol. 46, No. 8 ( 2016-08), p. 2018-2027
Abstract:
Regulatory mechanisms initiated by allergen‐specific immunotherapy are mainly attributed to T cell derived IL‐10. However, it has not been shown that T cell derived IL‐10 is required for successful tolerance induction (TI). Here, we analyze cellular sources and the functional relevance of cell type specific IL‐10 during TI in a murine model of allergic airway inflammation. While TI was effective in IL‐10 competent mice, neutralizing IL‐10 prior to tolerogenic treatment completely abrogated the beneficial effects. Cellular sources of IL‐10 during TI were identified by using transcriptional reporter mice as T cells, B cells, and to a lesser extent DCs. Interestingly, TI was still effective in mice with T cell, B cell, B and T cell, or DC‐specific IL‐10 deficiency. In contrast, TI was not possible in mice lacking IL‐10 in all hematopoetic cells, while it was effective in bone marrow (BM) chimera that lacked IL‐10 only in nonhematopoetic cells. Taken together, allergen‐specific tolerance depends on IL‐10 from hematopoetic sources. The beneficial effects of allergen‐specific immunotherapy cannot solely be attributed to IL‐10 from T cells, B cells, or even DCs, suggesting a high degree of cellular redundancy in IL‐10‐mediated tolerance.
Type of Medium:
Online Resource
ISSN:
0014-2980
,
1521-4141
DOI:
10.1002/eji.201646319
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
1491907-2
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