In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 16, No. 11 ( 2022-11-2), p. e0010787-
Abstract:
Madurella mycetomatis is one of the main causative agents of mycetoma, a debilitating neglected tropical disease. Improved understanding of the genomic diversity of the fungal and bacterial causes of mycetoma is essential to advances in diagnosis and treatment. Here, we describe a high-quality genome assembly of M . mycetomatis and results of the whole genome sequence analysis of 26 isolates from Sudan. We demonstrate evidence of at least seven genetically diverse lineages and extreme clonality among isolates within these lineages. We also performed shotgun metagenomic analysis of DNA extracted from mycetoma grains and showed that M . mycetomatis reads were detected in all sequenced samples with the average of 11,317 reads (s.d. +/- 21,269) per sample. In addition, 10 (12%) of the 81 tested grain samples contained bacterial reads including Streptococcus sp., Staphylococcus sp. and others.
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0010787
DOI:
10.1371/journal.pntd.0010787.g001
DOI:
10.1371/journal.pntd.0010787.g002
DOI:
10.1371/journal.pntd.0010787.g003
DOI:
10.1371/journal.pntd.0010787.t001
DOI:
10.1371/journal.pntd.0010787.t002
DOI:
10.1371/journal.pntd.0010787.t003
DOI:
10.1371/journal.pntd.0010787.s001
DOI:
10.1371/journal.pntd.0010787.s002
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2429704-5
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