In:
Proceedings, annual meeting, Electron Microscopy Society of America, Cambridge University Press (CUP), Vol. 48, No. 3 ( 1990-08-12), p. 310-311
Abstract:
A murine retrovirus construct encoding an avian v-myc oncogene (gift from B. Vennström EMBL, Heidelberg, F.R.G.) was injected into new born female NMRI mice. All mice developed malignant thymic lymphoblastic lymphoma within four months. Four of 9 mice also developed adenocarcinomas of the pancreas. Tissues were fixed in buffered formalin and samples from the pancreas tumours, lymph nodes, normal pancreas, liver and salivary gland were embedded in epon and examined by transmission electron microscopy. Large numbers of atypical virus-like particles were observed in all the samples from the pancreas tumours, normal pancreas and salivary gland, but only rare scattered particles in lymphomas. The pancreas tumours contained massive accumulations of particles in the intercellular spaces. In the normal pancreas, particles were preferentially located in pocketlike areas between the basal laminar and the surface of acinar cells (Fig.1), as well as in the narrow zone between adjoining acinar cells. Particles were occasionally seen budding from the cell surface.
Type of Medium:
Online Resource
ISSN:
0424-8201
,
2690-1315
DOI:
10.1017/S0424820100159102
Language:
English
Publisher:
Cambridge University Press (CUP)
Publication Date:
1990
SSG:
11
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