In:
JCR: Journal of Clinical Rheumatology, Ovid Technologies (Wolters Kluwer Health), Vol. 27, No. 6S ( 2021-9), p. S180-S185
Abstract:
The aim of this study was to determine the prevalence of depression among rheumatoid arthritis (RA) Argentinean patients and its association with sociodemographic and clinical factors. Methods We performed a cross-sectional study of consecutive adults with RA. Sociodemographic data, comorbidities, RA disease activity, and current treatment were assessed. The following instruments were used to evaluate quality of life (EQ-5D-3 L [EURO Quality 5-dimension 3 lines], QOL-RA [Quality of Life–Rheumatoid Arthritis] ), functional capacity (HAQ-A [Health Assessment Questionnaire–Argentinean version]), and depression (PHQ-9 [Patient Health Questionnaire 9] ; scores 5–9: mild, 10–14: moderate, 15–19: moderate-severe, and ≥20: severe depression, a cutoff value ≥10 is diagnostic of major depression). Results Two hundred fifty-eight patients were included, with a median disease duration of 9 years (interquartile range, 3.6–16.7 years). The m PHQ-9 score was 6 (interquartile range, 2–12.3 years). The prevalence of major depression was 33.8%. The frequency of mild, moderate, moderate/severe, and severe depression was 66 (25.6%), 42 (16.3%), 27 (10.5%), and 18 (7%), respectively. Patients with major depression had worse functional capacity (HAQ-A: mean ± SD, 1.6 ± 0.8 vs. 0.7 ± 0.7; p 〈 0.0001), poorer quality of life (QOL-RA: mean ± SD, 5.4 ± 1.8 vs. 7.3 ± 1.6; p 〈 0.0001), greater pain (visual analog scale: mean ± SD, 56.2 ± 27.5 mm vs. 33.4 ± 25.7 mm; p 〈 0.0001), higher disease activity (Disease Activity Score in 28 joints: mean ± SD, 4.3 ± 1.4 vs. 3.3 ± 1.3; p 〈 0.0001), higher frequency of comorbidities (67% vs. 33%; p = 0.017), and lower frequency of physical activity (22% vs. 35%; p = 0.032). In the multivariate analysis, patients with moderate and severe depression had worse functional capacity (odds ratio, 2.1; 95% confidence interval, 1.6–4.3; p 〈 0.0001) and quality of life (odds ratio, 0.7; 95% confidence interval, 0.5–0.8; p 〈 0.0001), independently of disease activity. Conclusions A third of RA patients in this Argentinean cohort had major depression. In those patients, depression was associated with worst functional capacity and quality of life.
Type of Medium:
Online Resource
ISSN:
1536-7355
,
1076-1608
DOI:
10.1097/RHU.0000000000001506
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2021
detail.hit.zdb_id:
2071025-2
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