In:
European Journal of Organic Chemistry, Wiley, Vol. 2020, No. 2 ( 2020-01-16), p. 162-168
Abstract:
A one‐pot reductive amination of aldehydes and ketones with NaBH 4 was developed with a view to providing efficient, economical and greener synthetic conditions. A recyclable iron‐based Lewis catalyst, Aquivion‐Fe, was used to promote imine formation in cyclopentyl methyl ether, followed by the addition of a small amount of methanol to the reaction mixture to enable C=N reduction by NaBH 4 . The protocol, applied to a wide number of amines and carbonyl compounds, resulted in ever complete conversion of these latter with excellent chemoselectivity towards the expected amination products in the most cases. Isolated yields, determined for a selection of the screened substrates, were found consistent with the previously obtained conversion and selectivity data. Cinacalcet, an important active pharmaceutical ingredient, was efficiently prepared by the title procedure.
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2020.2
DOI:
10.1002/ejoc.201901614
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1475010-7
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