In:
Journal of Pharmaceutical Negative Results, SynthesisHub Advance Scientific Research, ( 2022-10-31), p. 886-890
Abstract:
Introduction: Polycystic ovarian syndrome (PCOS) is a common endocrinological disorder of reproductive age female. The etiology of PCOS is not completely understood. Several publications nowadays demonstrate the relationship between chronic low-grade inflammation and mitochondrial dysfunctions induced by oxidative stress. Methods: This hospital based cross-sectional study, was conducted among reproductive age females. The study includes 73 obese PCOS, 55 Lean PCOS subjects and 15 non-obese PCOS subjects on the basis on transvaginal sonography and BMI. The anthropometric parameters were: BMI, Waist Hip Ratio (WHR), systolic and diastolic blood pressure by sphygmomanometer. Serum samples were collected to measure: oxidative stress (MDA), lipid profile, and pro-inflammatory cytokines (HsCRP, IL-6, IL-18 & TNF-α). Results: The BMI and MDA levels were significant in obese-PCOS and lean PCOS group (p 〈 0.001). Whereas, in the obese-PCOS and non-PCOS obese group MDA, triglycerides, HDL, VLDL, IL-6, IL-18, and TNF-α were significant respectively. Conclusion: It concluded from this study that obesity may contribute to dyslipidemia and elevated oxidative stress levels in reproductive age females irrespective of PCOS. Therefore, obesity in addition to known features such as dyslipidemia, hypertension and disturbed oxidative stress response, may be contributing factors to increase the risk of future cardiovascular diseases in obese women.
Type of Medium:
Online Resource
ISSN:
2229-7723
,
0976-9234
DOI:
10.47750/pnr.2022.13.S07.121
Language:
Unknown
Publisher:
SynthesisHub Advance Scientific Research
Publication Date:
2022
detail.hit.zdb_id:
2632010-1
SSG:
15,3
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