In:
Helvetica Chimica Acta, Wiley, Vol. 87, No. 10 ( 2004-10), p. 2574-2580
Abstract:
Three new flavonoids, which are isoprenylated by fused 2,2‐dimethyl‐3,4‐dihydro‐2 H ‐pyran moieties, were isolated from the roots of Sophora flavescens and named flavenochromanes A–C ( 1 – 3 ). Their structures were elucidated by spectroscopic methods, including 2D‐NMR techniques. Flavenochromane C ( 3 ) showed strong cytotoxic activity against A549 (lung carcinoma), 1A9 (ovarian carcinoma), KB (epidermoid carcinoma of the nasopharynx), and KB‐Vin (drug‐resistant variant KB) cell lines with IC 50 values ≤1.7 μ M , and significant activity against the MCF‐7 (breast adenocarcinoma) cell line with an IC 50 value of 3.6 μ M . Flavenochromane B ( 2 ) displayed slightly lower inhibitory effects ( IC 50 3.2–6.9 μ M ) as compared with 3 .
Type of Medium:
Online Resource
ISSN:
0018-019X
,
1522-2675
DOI:
10.1002/hlca.200490230
Language:
English
Publisher:
Wiley
Publication Date:
2004
detail.hit.zdb_id:
74-7
detail.hit.zdb_id:
1475013-2
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