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  • 1
    Online Resource
    Online Resource
    Restoration of growth plate function following radiotherapy is driven by increased proliferative and synthetic activity of expansions of chondrocytic clones : PROLIFERATIVE AND SYNTHETIC ACTIVITY OF CHONDROCYTIC CLONES
    Wiley ; 2006
    In:  Journal of Orthopaedic Research Vol. 24, No. 10 ( 2006-10), p. 1945-1956
    Details
    In: Journal of Orthopaedic Research, Wiley, Vol. 24, No. 10 ( 2006-10), p. 1945-1956
    Type of Medium: Online Resource
    ISSN: 0736-0266
    URL: Issue
    URL: Article
    DOI: 10.1002/jor.v24:10
    DOI: 10.1002/jor.20251
    Language: English
    Publisher: Wiley
    Publication Date: 2006
    detail.hit.zdb_id: 2050452-4
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  • 2
    Online Resource
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    Ontogeny of Skeletal Maturation in the Juvenile Rat
    Wiley ; 2008
    In:  The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology Vol. 291, No. 3 ( 2008-03), p. 283-292
    Details
    In: The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, Wiley, Vol. 291, No. 3 ( 2008-03), p. 283-292
    Type of Medium: Online Resource
    ISSN: 1932-8486 , 1932-8494
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.1002/ar.v291:3
    DOI: 10.1002/(ISSN)1932-8494
    DOI: 10.1002/ar.20650
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2273240-8
    detail.hit.zdb_id: 2109216-3
    SSG: 12
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  • 3
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    Gait abnormalities in patients with chronic ankle instability can improve following a non-invasive biomechanical therapy: a retrospective analysis
    Society of Physical Therapy Science ; 2017
    In:  Journal of Physical Therapy Science Vol. 29, No. 4 ( 2017), p. 677-684
    Details
    In: Journal of Physical Therapy Science, Society of Physical Therapy Science, Vol. 29, No. 4 ( 2017), p. 677-684
    Type of Medium: Online Resource
    ISSN: 0915-5287 , 2187-5626
    URL: Article
    DOI: 10.1589/jpts.29.677
    Language: English
    Publisher: Society of Physical Therapy Science
    Publication Date: 2017
    detail.hit.zdb_id: 2038898-6
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  • 4
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    Online Resource
    Lower Extremity Fractures in Hospitalized Pediatric Patients Following Road Traffic Accidents
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Pediatric Emergency Care Vol. 35, No. 12 ( 2019-12), p. 862-867
    Details
    In: Pediatric Emergency Care, Ovid Technologies (Wolters Kluwer Health), Vol. 35, No. 12 ( 2019-12), p. 862-867
    Abstract: Lower extremity fractures (LEFs) caused by road traffic accidents (RTAs) can result in significant morbidity and account for a substantial part of nonfatal injuries requiring hospitalization. This study investigated the epidemiology of RTA-associated LEFs in the pediatric population. Based on the National Trauma Registry, data of 28,924 RTA hospitalized pediatric patients were reviewed. Data were analyzed according to LEF mechanism of injury, age distribution, fracture types, associated injuries, surgical treatment, and their interrelations. A total of 4970 (17.18%) sustained LEFs, with the highest risk for motorcycle-associated RTA, followed by pedestrians. Approximately 1 of 4 patients had multiple fractures. Forty percent (2184 cases) sustained additional injuries, for which car-associated RTAs were at the greatest risk (61%, P 〈 0.0001), followed by pedestrians and motorcycles (46%–45%, P 〈 0.0001). Overall, head/neck/face injuries were the most commonly associated injuries. The tibia was the most fractured bone (42%), followed by the femur, fibula, foot, and ankle. This distribution varied according to RTA mechanism. Forty-one percent of cases required fracture treatment in an operating room. As patients were older, the greater the chance they required further treatment in the operating room ( P 〈 0.0001). This large-scale study on the epidemiology of LEFs in the pediatric population following RTA provides unique information on epidemiological characteristics of LEF, pertinent both to medical care providers and to health policy makers allocating resources and formulating prevention strategies in the attempt to deal with the burden of road traffic accidents. Level of Evidence: Prognostic and epidemiologic study, level II.
    Type of Medium: Online Resource
    ISSN: 1535-1815 , 0749-5161
    URL: Article
    DOI: 10.1097/PEC.0000000000001504
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2053985-X
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  • 5
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    Orthopedic Surgery Resident Debt Load and Its Effect on Career Choice
    SLACK, Inc. ; 2016
    In:  Orthopedics Vol. 39, No. 3 ( 2016-05)
    Details
    In: Orthopedics, SLACK, Inc., Vol. 39, No. 3 ( 2016-05)
    Abstract: Student loan debt has become a topic of discussion and debate among physicians and legislators. This study seeks to assess the level of debt of orthopedic surgery residents and to determine whether debt burden affects the career choice of orthopedic trainees. A 26-question, anonymous survey was distributed via email to resident trainees enrolled in different medical and surgical specialty training programs across the United States. Orthopedic trainees were compared with trainees in other specialties using comparative statistics. Of the approximately 13,503 residents who were sent the survey, a total of 3076 responded, including 167 of an estimated 580 orthopedic residents, for approximate response rates of 22.8% and 28.8%, respectively. On average, orthopedic surgery residents were at a later post-graduate year than overall respondents ( P 〈 .025). When asked if student loan debt would influence the next step in their career, nonorthopedic residents were statistically more likely to respond “yes” compared with orthopedic surgery residents (57.21% vs 49.08%, respectively; P =.041). More than 50% of all respondents agreed that student loan debt would affect their type or location of practice. The majority of orthopedic residents take student loan debt into consideration when determining their final location and type of practice, although less so for orthopedic trainees compared with other specialties. As medical education continues to become more expensive and the threat of dropping physician reimbursement looms on the horizon, student debt may become a primary driving factor for young American physicians' career plans. [ Orthopedics. 2016; 39(3):e438–e443.]
    Type of Medium: Online Resource
    ISSN: 0147-7447 , 1938-2367
    URL: Article
    DOI: 10.3928/01477447-20160315-01
    Language: English
    Publisher: SLACK, Inc.
    Publication Date: 2016
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  • 6
    Online Resource
    Online Resource
    Complications of Lesser Toe Surgery
    Elsevier BV ; 2022
    In:  Foot and Ankle Clinics Vol. 27, No. 2 ( 2022-06), p. 233-251
    Details
    In: Foot and Ankle Clinics, Elsevier BV, Vol. 27, No. 2 ( 2022-06), p. 233-251
    Type of Medium: Online Resource
    ISSN: 1083-7515
    URL: Article
    DOI: 10.1016/j.fcl.2021.11.021
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
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  • 7
    Online Resource
    Online Resource
    Impact of Vancomycin Treatment on Human Mesenchymal Stromal Cells During Osteogenic Differentiation
    SAGE Publications ; 2018
    In:  Foot & Ankle International Vol. 39, No. 8 ( 2018-08), p. 954-959
    Details
    In: Foot & Ankle International, SAGE Publications, Vol. 39, No. 8 ( 2018-08), p. 954-959
    Abstract: Vancomycin is frequently applied locally to the operative site during foot and ankle procedures to help prevent infection. Although the efficacy of locally applied vancomycin has been demonstrated in spine surgery, there is no consensus on dosing and indication within foot and ankle surgery. Osteogenic differentiation of human mesenchymal stromal cells (hMSCs) is key to healing of both fractures and arthrodesis. The purpose of this research was to determine the impact of vancomycin on human hMSCs during the process of osteogenic differentiation. Methods: hMSCs were cultured in osteogenic differentiation media to promote osteogenic differentiation. Cells were treated with vancomycin at differing concentrations of 0, 50, 500, and 5000 µg/mL. Viability and cell growth were assessed via LIVE/DEAD viability/cytotoxicity kit (Invitrogen, Waltham, MA) after 1, 3, and 7 days of vancomycin treatment. Differentiation and mineralization was assessed via alizarin red staining after 21 days of treatment. Mean cell viability, cell number, and mineralization were compared between treatment groups using 1-way analysis of variance and the Tukey-Kramer method for post hoc pairwise comparisons. Results: At the highest concentrations of vancomycin, there was a significant reduction in cell viability and proliferation after 3 days compared with all other treatment groups. Mineralization was also significantly decreased with higher doses of vancomycin. Conclusion: At high concentrations, vancomycin may impair hMSC viability and osteogenic differentiation. Clinical Relevance: Surgeons should exercise caution and consider the limited soft tissue envelope when applying vancomycin locally during foot and ankle surgery, especially during arthrodesis procedures.
    Type of Medium: Online Resource
    ISSN: 1071-1007 , 1944-7876
    URL: Article
    DOI: 10.1177/1071100718766655
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2129503-7
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  • 8
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    Association of Strength Following Achilles Tendon Repair With Return to Same Level of Play in High-Level Athletes
    SAGE Publications ; 2020
    In:  Foot & Ankle International Vol. 41, No. 9 ( 2020-09), p. 1041-1048
    Details
    In: Foot & Ankle International, SAGE Publications, Vol. 41, No. 9 ( 2020-09), p. 1041-1048
    Abstract: Rupture of the Achilles tendon is a common injury and the ability to return to the same level of sporting activity after treatment is an important outcome for patients. The objective of the current study was to examine the relationship between ankle strength and the ability to return to previous level of play following operative repair of an Achilles tendon rupture. Methods: Patients aged 18 to 50 years at a minimum 1 year postoperation from surgical repair of an Achilles tendon returned for a study visit. Patients reported both preinjury and current activity level using the 10-point Tegner Activity Level Scale. Isokinetic strength testing was performed and the Isokinetic Strength Score (ISS) was calculated. Logistic regression analysis was used to determine the relationship between ISS and return to play by Tegner level. A total of 36 patients (mean 35 years old, 72% male) completed the study protocol at a mean 1.8 years postoperatively. Results: Logistic regression revealed no association between ISS and return to play in the complete cohort. Subgroup analysis revealed that for 20 high-level athletes (preinjury Tegner ≥ 7), for every 16-point increase in ISS, the odds ratio (OR) for return to same level of play was 8.3 ( P = .055) and the OR for return to within 1 Tegner level of play was 6.3 ( P = .043). There was no association between ISS and return to previous activity in the 16 patients with lower preinjury levels of activity. Conclusion: Improved ankle strength was associated with return to previous level of activity in patients participating in high-level athletic activity, suggesting that these patients were more dependent on recovery of ankle strength in the postoperative time period in order to return to their previous high level of play. In contrast, regaining strength may be less important for returning to normal activities for less active patients. Level of Evidence: Level III, comparative series.
    Type of Medium: Online Resource
    ISSN: 1071-1007 , 1944-7876
    URL: Article
    DOI: 10.1177/1071100720936276
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2129503-7
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  • 9
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    Development of a Small Animal Ankle Arthrodesis Model
    SAGE Publications ; 2020
    In:  Foot & Ankle International Vol. 41, No. 1 ( 2020-01), p. 101-108
    Details
    In: Foot & Ankle International, SAGE Publications, Vol. 41, No. 1 ( 2020-01), p. 101-108
    Abstract: Our understanding of the biology of ankle arthrodesis is based largely on work in spine and long bone animal models. However, the local soft tissue and vascular anatomy of the foot and ankle is different from that of the spine. Accordingly, the objective of this study was to develop a small animal ankle arthrodesis model. Methods: A total of 12 Lewis rats successfully underwent ankle arthrodesis with stabilization consisting of a single Kirschner wire across the prepared tibiotalar joint. Based on high nonunion rates with this initial procedure, a modification was made consisting of a second pin crossing the joint. A total of 6 rats underwent the second procedure. Radiographs were taken postoperatively and in 2-week intervals up to 10 weeks. Micro computed tomography (µCT) and histological analysis was conducted at 10 weeks to assess the fusion mass. Osseous bridging of greater than 50% across the tibiotalar joint was deemed a successful fusion. Results: µCT analysis determined that 11 of the 12 rats in the single-pin cohort developed nonunions (8.3% fusion rate). In the dual-pin cohort, all 6 animals successfully fused (100% fusion rate). Histological analysis supported the radiographic imaging conclusions. Conclusion: While the initial procedure had a high nonunion rate, enhancing the stability of the fixation greatly increased the union rate. Clinical Relevance: The present work demonstrates the first reliable small animal ankle arthrodesis model. We believe that this model can be used in the development of novel therapies aimed at decreasing complications and increasing fusion rates.
    Type of Medium: Online Resource
    ISSN: 1071-1007 , 1944-7876
    URL: Article
    DOI: 10.1177/1071100719873900
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2129503-7
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  • 10
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    Mobility Limitation After Surgery for Degenerative Pathology of the Ankle, Hindfoot, and Midfoot vs Total Hip Arthroplasty
    SAGE Publications ; 2020
    In:  Foot & Ankle International Vol. 41, No. 5 ( 2020-05), p. 501-507
    Details
    In: Foot & Ankle International, SAGE Publications, Vol. 41, No. 5 ( 2020-05), p. 501-507
    Abstract: Surgery for degenerative foot and ankle conditions often results in a lengthy recovery. Current outcome measures do not accurately assess postoperative mobility, especially in older patients. The Life-Space Assessment (LSA), a questionnaire quantifying patients’ mobility after a medical event, was used in this study to assess perioperative mobility in total hip arthroplasty (THA) and foot and ankle surgery patients. We hypothesized that patients undergoing elective foot and ankle surgery would have greater postoperative mobility limitation than THA patients. Methods: Preoperative, 3-month, and 6-month postoperative LSA data were collected from THA and foot and ankle cohorts. Twelve-month postoperative data were obtained for the foot and ankle group as well. Patient demographics were recorded, and data were analyzed using a Mann-Whitney U test. Results: Twenty-eight degenerative foot and ankle operative patients and 38 THA patients met inclusion criteria. Only patients aged ≥60 years were included in this study. The mean preoperative LSA score was lower in the foot and ankle group (68.8) compared with THA (74.0), although the difference was not statistically significant ( P = .602). THA patients showed a significant increase in LSA score from preoperative (74) to 6 months postoperation (95.9) ( P = .003); however, foot and ankle patients showed no significant difference between preoperative (68.8) and 6-month (61.2) scores ( P = .468). Twelve months postoperatively, foot and ankle patients showed improvement in LSA score (88.3) compared with preoperation ( P = .065). Conclusion: Compared with THA, recovery of mobility after foot and ankle surgery was slower. THA patients exhibited improved mobility as early as 3 months after surgery, whereas foot and ankle patients did not show full improvement until 12 months. This work will assist the foot and ankle specialist in educating patients about challenges in mobility during their recovery from surgery. Level of Evidence: Level II, prospective cohort study.
    Type of Medium: Online Resource
    ISSN: 1071-1007 , 1944-7876
    URL: Article
    DOI: 10.1177/1071100720907034
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2129503-7
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