In:
International Journal of Dermatology, Wiley, Vol. 54, No. 6 ( 2015-06), p. 672-674
Abstract:
Vitiligo is a common progressive depigmentation of the skin due to selective destruction of melanocytes. Nowadays increasing evidences support the hypothesis of an autoimmune etiology. Methods In order to sustain the role of T‐helper‐17 lymphocytes in the pathogenesis of vitiligo, we measured the serum levels of interleukin ( IL )‐23 (an important regulator of this subset) using a quantitative enzyme immunoassay technique in 12 males and 16 females (ages ranging from 18 to 58 years) affected by non‐segmental vitiligo and compared the results with a group of healthy donors. Results IL ‐23 serum levels were significantly higher in patients with vitiligo as compared with controls. There was a significant positive correlation of IL ‐23 serum levels with disease duration and extent of vitiligo and disease activity. Conclusions The inhibition of IL ‐23 might be a novel strategy in the therapy of autoimmune inflammatory diseases like vitiligo.
Type of Medium:
Online Resource
ISSN:
0011-9059
,
1365-4632
DOI:
10.1111/ijd.2015.54.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2020365-2
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