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  • 1
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Annals of Medicine & Surgery Vol. 85, No. 4 ( 2023-03-25), p. 931-933
    In: Annals of Medicine & Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 85, No. 4 ( 2023-03-25), p. 931-933
    Abstract: Thyrotoxic periodic paralysis (TPP) is a rare complication of hyperthyroidism characterized by episodes of muscle weakness and hypokalemia. Patients may present with a sudden onset of muscle weakness. Though hyperthyroidism occurs more commonly in females, TPP typically occurs in young males in their third decade. Case Presentation: This is a case of a 32-year-old male who presented to the emergency room with a sudden onset of weakness in bilateral upper and lower limbs, which progressed to complete paralysis in an hour. A provisional diagnosis of hypokalemic periodic paralysis was made and admitted. Later, on further diagnostic workup, the final diagnosis of TPP was made. Discussion: Clinical features of hyperthyroidism in patients with TPP may be subtle. With immediate potassium supplementation, serious cardiopulmonary complications can be prevented and may hasten the recovery of muscle weakness. Nonselective β-adrenergic blockers can lessen and prevent the recurrence of paralytic attacks. Conclusion: This case is reported with the objective of generating awareness regarding the clues to the diagnosis, appropriate management, and definitive treatment to a render euthyroid state in order to prevent future recurrence of similar episodes and prevent any complications, and eventually to raise the index of suspicion among treating physicians in cases that present with paralysis in clinical practice.
    Type of Medium: Online Resource
    ISSN: 2049-0801
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2745440-X
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  • 2
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2023
    In:  South Asian Journal of Cancer Vol. 12, No. 01 ( 2023-01), p. 053-054
    In: South Asian Journal of Cancer, Georg Thieme Verlag KG, Vol. 12, No. 01 ( 2023-01), p. 053-054
    Type of Medium: Online Resource
    ISSN: 2278-330X , 2278-4306
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2023
    detail.hit.zdb_id: 2719571-5
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  • 3
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2023
    In:  South Asian Journal of Cancer Vol. 12, No. 01 ( 2023-01), p. e1-e1
    In: South Asian Journal of Cancer, Georg Thieme Verlag KG, Vol. 12, No. 01 ( 2023-01), p. e1-e1
    Type of Medium: Online Resource
    ISSN: 2278-330X , 2278-4306
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2023
    detail.hit.zdb_id: 2719571-5
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  • 4
    In: BMC Health Services Research, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)
    Abstract: Cardiovascular diseases (CVDs) are the leading cause of deaths and disability in Nepal. Health systems can improve CVD health outcomes even in resource-limited settings by directing efforts to meet critical system gaps. This study aimed to identify Nepal’s health systems gaps to prevent and manage CVDs. Methods We formed a task force composed of the government and non-government representatives and assessed health system performance across six building blocks: governance, service delivery, human resources, medical products, information system, and financing in terms of equity, access, coverage, efficiency, quality, safety and sustainability. We reviewed 125 national health policies, plans, strategies, guidelines, reports and websites and conducted 52 key informant interviews. We grouped notes from desk review and transcripts’ codes into equity, access, coverage, efficiency, quality, safety and sustainability of the health system. Results National health insurance covers less than 10% of the population; and more than 50% of the health spending is out of pocket. The efficiency of CVDs prevention and management programs in Nepal is affected by the shortage of human resources, weak monitoring and supervision, and inadequate engagement of stakeholders. There are policies and strategies in place to ensure quality of care, however their implementation and supervision is weak. The total budget on health has been increasing over the past five years. However, the funding on CVDs is negligible. Conclusion Governments at the federal, provincial and local levels should prioritize CVDs care and partner with non-government organizations to improve preventive and curative CVDs services.
    Type of Medium: Online Resource
    ISSN: 1472-6963
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2050434-2
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  • 5
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2015 ( 2015), p. 1-5
    Abstract: Objectives . To assess thyroid function and associated risk factors in Nepalese diabetes mellitus patients. Methods . A cross-sectional study was carried out among 419 diabetes mellitus patients at B. P. Koirala Institute of Health Sciences, Dharan, Nepal. Information on demographic and anthropometric variables and risk factors for thyroid dysfunction was collected. Blood samples were analysed to measure thyroid hormones, blood sugar, and lipid profile. Results . Prevalence rate of thyroid dysfunction was 36.03%, with subclinical hypothyroidism (26.5%) as the most common thyroid dysfunction. Thyroid dysfunction was much common in females (42.85%) compared to males (30.04%) p = 0.008 and in type 1 diabetes (50%) compared to type 2 diabetes mellitus (35.41%) p = 0.218 . Diabetic patients with thyroid dysfunction had higher total cholesterol, HDL cholesterol, and LDL cholesterol in comparison to patients without thyroid dysfunction. Significant risk factors for thyroid dysfunction, specifically hypothyroidism (overt and subclinical), were smoking (relative risk of 2.56 with 95% CI (1.99–3.29, p 〈 0.001 )), family history of thyroid disease (relative risk of 2.57 with 95% CI (2.0–3.31, p 〈 0.001 )), and female gender (relative risk of 1.44 with 95% CI (1.09–1.91, p = 0.01 )). Conclusions . Thyroid dysfunction is common among Nepalese diabetic patients. Smoking, family history of thyroid disease, and female gender are significantly associated with thyroid dysfunction.
    Type of Medium: Online Resource
    ISSN: 1687-8337 , 1687-8345
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2502951-4
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  • 6
    Online Resource
    Online Resource
    Wiley ; 1974
    In:  Chemischer Informationsdienst Vol. 5, No. 37 ( 1974-09-17), p. no-no
    In: Chemischer Informationsdienst, Wiley, Vol. 5, No. 37 ( 1974-09-17), p. no-no
    Type of Medium: Online Resource
    ISSN: 0009-2975
    URL: Issue
    Language: German
    Publisher: Wiley
    Publication Date: 1974
    detail.hit.zdb_id: 2110203-X
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  • 7
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2011
    In:  The Indian Journal of Pediatrics Vol. 78, No. 1 ( 2011-1), p. 45-48
    In: The Indian Journal of Pediatrics, Springer Science and Business Media LLC, Vol. 78, No. 1 ( 2011-1), p. 45-48
    Type of Medium: Online Resource
    ISSN: 0019-5456 , 0973-7693
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2011
    detail.hit.zdb_id: 2065273-2
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  • 8
    In: Globalization and Health, Springer Science and Business Media LLC, Vol. 19, No. 1 ( 2023-04-25)
    Abstract: The monitoring and improvement of the health of labour migrants (LMs) require sufficient health data to be recorded and managed. In this context, this study was conducted to explore the management of health information of Nepalese labour migrants (NLMs). Methods This is an explorative qualitative study. Stakeholders involved directly or indirectly in maintaining the health profile of NLMs were first mapped, physically visited, and any documents or information were collected. Then, sixteen key informant interviews were conducted among these stakeholders related to labour migrants’ health information management and challenges. A checklist extracted information from the interviews, and a thematic analysis was carried out to summarize the challenges. Results Government agencies, non-governmental organizations, and government approved private medical centers are involved in generating and maintaining the health data of NLMs. The Foreign Employment Board (FEB) records deaths and disabilities of NLMs while at work abroad and these health records are also maintained in an online portal called Foreign Employment Information Management System (FEIMS) under the Department of Foreign Employment (DoFE). Health assessment of NLMs is a mandatory procedure before departure, which is done through the government-approved pre-departure private medical assessment centers. The health records from these assessment centers are first recorded in paper-based form and then entered into an online electronic form to be stored by the DoFE. The filled-up paper forms are sent to District Health Offices, which further report the data to the Department of Health Services (DoHS), Ministry of Health and Population (MoHP) and associated governmental infectious diseases centers. However, there is no formal health assessment of NLMs upon arrival to Nepal. Key informants raised various issues and concerns in maintaining health records of NLMs, which were grouped into three themes: lack of interest to develop a unified online system; need of competent human resources and equipment; and developing a set of health indicators for migrant health assessment. Conclusion The FEB and government-approved private assessment centers are the main stakeholders in keeping the health records of outgoing NLMs. The current migrant health record keeping procedure in Nepal is fragmented. The national Health Information Management Systems does not effectively capture and categorize the health record of NLMs. There is a need to effectively link national health information system with premigration health assessment centers; and potentially develop a migrant health information management system by systematically keeping health records electronically with relevant health indicators on departing and arriving NLMs.
    Type of Medium: Online Resource
    ISSN: 1744-8603
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2185774-X
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  • 9
    Online Resource
    Online Resource
    Nepal Journals Online (JOL) ; 2019
    In:  Journal of College of Medical Sciences-Nepal Vol. 15, No. 1 ( 2019-03-03), p. 18-21
    In: Journal of College of Medical Sciences-Nepal, Nepal Journals Online (JOL), Vol. 15, No. 1 ( 2019-03-03), p. 18-21
    Abstract: Background: Iron deficiency is the most common nutritional deficiency in the world. The relation between thyroid hormones and iron status is bidirectional. The aim of this study was to assess iron nutrition status and evaluate its relationship with thyroid hormone profile among children of Eastern Nepal. Methods: A  community based cross-sectional study was conducted in eastern Nepal. A total of 200 school children aged 6-12 years were recruited after taking informed consent from their guardians. Blood samples were collected and assayed for free thyroid hormones (fT3 and fT4), thyroid stimulating hormone (TSH), serum iron, total iron binding capacity (TIBC) concentration and percentage transferrin saturation was calculated. Results: The mean serum iron and TIBC was 74.04 µg/dl and 389.38 µg/dl respectively. The median transferring saturation was 19.21%. The overall prevalence of iron deficiency (Transferrin saturation 〈 16%) was 34% (n=68). The mean concentration of fT3 and fT4 was 2.87 pg/ml and 1.21 ng/dl respectively, while the median TSH concentration was 3.03 mIU/L. Median TSH concentration in iron deficient group (3.11 µg/dl) and iron sufficient group (2.91 µg/dl) was not significantly different. Among iron deficient children 5.9% had   subclinical hypothyroidism (n=4). Iron status indicators were not significantly correlated with thyroid profile parameters in the study population. Conclusions: The prevalence of iron deficiency is high and iron   deficiency does not significantly alter the thyroid hormone profile in the study region.
    Type of Medium: Online Resource
    ISSN: 2091-0673 , 2091-0657
    Language: Unknown
    Publisher: Nepal Journals Online (JOL)
    Publication Date: 2019
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  • 10
    In: International Journal of Molecular & Immuno Oncology, Scientific Scholar, Vol. 6 ( 2021-05-29), p. 61-65
    Abstract: We present the survey data on molecular testing and its implications among lung cancer specialists in the South Asian Association for Regional Cooperation (SAARC) region. Material and Methods: An online survey Google form was developed that could be completed in 〈 5 min. This was circulated to oncologists who had been actively participated in our academic activities and this data were collected over an 11 day period in November 2020. Results: We had 354 responders from 8 SAARC countries, 58.9% (209/354) being medical oncologists, and 30.1% (107/354) radiation oncologists. Nearly 50% of responders were seeing patients in the second wave of coronavirus disease 2019 and 89% had seen reduction in their lung cancer patients during first wave. Biomarker testing in advanced lung cancer using next-generation sequencing as the preferred method was more among medical oncologists (76%) as compared to all the other specialists (24%); (Pearson Chi-square = 0.006). The practice of waiting for the molecular testing report before starting first line treatment was 55.4% in corporate/private hospitals as compared to 27% in the government/charity hospital sectors (Pearson Chi-square = 0.015). A total of 89.6% responders believed that targeted therapy has resulted in improved overall survival in advanced lung cancer. Conclusion: Educational activities need to be strengthened so that lung cancer specialists follow comprehensive NGS testing in appropriate settings, as shown by medical oncologists
    Type of Medium: Online Resource
    ISSN: 2456-3994
    Language: English
    Publisher: Scientific Scholar
    Publication Date: 2021
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