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  • 1
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    Online Resource
    Identifying sources of support and barriers to physical activity in pediatric type 1 diabetes
    Hindawi Limited ; 2020
    In:  Pediatric Diabetes Vol. 21, No. 1 ( 2020-02), p. 128-134
    Details
    In: Pediatric Diabetes, Hindawi Limited, Vol. 21, No. 1 ( 2020-02), p. 128-134
    Type of Medium: Online Resource
    ISSN: 1399-543X , 1399-5448
    URL: Issue
    URL: Article
    DOI: 10.1111/pedi.v21.1
    DOI: 10.1111/pedi.12938
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2025536-6
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  • 2
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    Halotherapy as asthma treatment in children: A randomized, controlled, prospective pilot study
    Wiley ; 2017
    In:  Pediatric Pulmonology Vol. 52, No. 5 ( 2017-05), p. 580-587
    Details
    In: Pediatric Pulmonology, Wiley, Vol. 52, No. 5 ( 2017-05), p. 580-587
    Abstract: Asthma is a chronic inflammatory disorder requiring intermittent or continuous anti‐inflammatory therapy. Patients often turn to alternative treatments as complements or replacements to conventional treatments. We aimed to evaluate the effect of salt room chambers (halotherapy) on bronchial hyper‐responsiveness (BHR), fractional exhaled nitric oxide (FeNO), and quality of life in children with asthma. Patients and Methods Children aged 5–13 years with a clinical diagnosis of mild asthma not receiving anti‐inflammatory therapy. Patients were randomized in this double‐blind, controlled study to salt room with halogenerator (treatment group), or without halogenerator (control group). We evaluated the effect of salt room therapy on BHR, FeNO, spirometry, and pediatric asthma quality of life questionnaire (PAQLQ). The treatment period lasted 7 weeks, 14 sessions. Results Twenty‐nine patients were randomized to the salt room with halogenerator (treatment group), and 26 patients to the salt room without salt halogenerator (control group). A statistically significant improvement in BHR was demonstrated in the treatment group, which remained unchanged in the control group. There was no improvement in spirometry or FeNO levels following treatment. The treatment group showed a statistical improvement in most parameters of quality of life questionnaires. Conclusions Our pilot study suggests that salt room with halogenerator, may have some beneficial effects in mild asthmatic children. Randomized and larger controlled trials with long‐term follow‐up are necessary. Pediatr Pulmonol. 2017;52:580–587. © 2016 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 8755-6863 , 1099-0496
    URL: Issue
    URL: Article
    DOI: 10.1002/ppul.v52.5
    DOI: 10.1002/ppul.23621
    Language: English
    Publisher: Wiley
    Publication Date: 2017
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  • 3
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    Effect of late preterm birth on lung clearance index and respiratory physiology in school‐age children
    Wiley ; 2019
    In:  Pediatric Pulmonology Vol. 54, No. 8 ( 2019-08), p. 1250-1256
    Details
    In: Pediatric Pulmonology, Wiley, Vol. 54, No. 8 ( 2019-08), p. 1250-1256
    Abstract: We hypothesized that former late preterm (LP) children have abnormal pulmonary physiology parameters, including uneven ventilation distribution, due to premature disruption of normal lung development. Methods A cross‐sectional study evaluating former LP children at the age of 6 to 12 years as compared to term controls. Demographics and child's and family history of asthma/atopy/smoking were recorded. The outcome parameters were spirometry, multiple breath washout (MBW) measurement by lung clearance index (LCI), 6‐minute walk test (6MWT), symptoms related to asthma and allergy, and Godin Leisure‐Time Exercise Questionnaire. Results Twenty‐nine former LP were compared to 30 term‐control children (mean age, 8.2 ± 1.7 and 8.8 ± 1.8 years, respectively). LP had reduced forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC) compared to term controls (FEV1 1.59 ± 0.48 vs 1.80 ± 0.39 L, P =  0.005 and FVC 1.73 ± 0.45 vs 1.99 ± 0.49 L, P  = 0.009). There were no differences between the two groups regarding FEV1/FVC, forced expiratory flow between 25 and 75 (FEF25‐75), LCI (7.10 ± 0.79 vs 6.96 ± 0.75, P  = 0.50), 6MW distance, and weekly leisure‐activity score. Former LP children had more episodes of wheezing and greater use of asthma medication. Conclusions This pilot study suggests that LP have lower pulmonary function tests (PFTs) but not ventilation inhomogeneity measured by LCI or functional disturbance. It is unclear if the differences in PFTs are due to late prematurity by itself or are the consequence of maternal and neonatal factors associated with LP. Further larger studies are required to assess the long‐term respiratory consequences of LP birth.
    Type of Medium: Online Resource
    ISSN: 8755-6863 , 1099-0496
    URL: Issue
    URL: Article
    DOI: 10.1002/ppul.v54.8
    DOI: 10.1002/ppul.24357
    Language: English
    Publisher: Wiley
    Publication Date: 2019
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  • 4
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    Understanding the interplay between factors that influence bone mineral density in CF
    Wiley ; 2020
    In:  Pediatric Pulmonology Vol. 55, No. 10 ( 2020-10), p. 2667-2673
    Details
    In: Pediatric Pulmonology, Wiley, Vol. 55, No. 10 ( 2020-10), p. 2667-2673
    Abstract: Multiple factors affect bone mineral density (BMD) in cystic fibrosis (CF). Our aim was to perform comprehensive analyses of parameters potentially contributing to BMD. Methods A prospective single‐center study assessing BMD, and correlations with multiple parameters including pancreatic status, lung functions, 6‐minute walk test (6MWT), clinical score (modified Shwachman‐Kulczycki [SK] score), vitamin D, nutritional intake, hand grip strength (HGS), habitual physical activity (smart watches), and quality of life (SF‐36 questionnaire). Results Forty CF patients, mean age 18.3 ± 8.1 years, forced expiratory volume in 1 second 74.7% ± 17.9% predicted. Fifteen (37.5%) and 11 (27.5%) had osteopenia and osteoporosis, respectively. BMD was similar in pancreatic sufficient (pancreatic sufficient [PS], n = 15) and insufficient (pancreatic insufficient [PI] , n = 25); median hip z score −1.5 ((−2.7)−(+0.2)) vs −1.5 ((−3.5)−(+0.7)), P  = .79; spine −0.8 ((−2.2)−(+2)) vs −1.2 ((−4.4)−(+1.5)), P  = .39 in PS vs PI, respectively. BMD correlated with HGS ( r  = .72, P   〈  .001 hip; r  = .52, P  = .001 spine) and fat‐free mass index ( r  = .81, P   〈  .001 hip; r  = .63, P   〈  .001 spine). BMD z score correlated weakly with SK score and moderately with SF‐36 general health. Data from smart watches, nutrition questionnaires, and 6MWT did not correlate with BMD. In a multivariate model, age and SK score predicted spine z score BMD. Conclusions A substantial number of CF patients have low BMD. Similar rates in PS and PI suggest that other factors, such as disease severity, may contribute to low BMD. SK and age, which can easily be obtained even with limited resources, were the best predictors of low BMD. Further larger multicenter studies are warranted to evaluate the contribution of multifactorial etiologies to low BMD in CF.
    Type of Medium: Online Resource
    ISSN: 8755-6863 , 1099-0496
    URL: Issue
    URL: Article
    DOI: 10.1002/ppul.v55.10
    DOI: 10.1002/ppul.24925
    Language: English
    Publisher: Wiley
    Publication Date: 2020
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  • 5
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    Foreign body aspiration in Israeli children during the COVID‐19 pandemic
    Wiley ; 2023
    In:  Pediatric Pulmonology Vol. 58, No. 2 ( 2023-02), p. 425-432
    Details
    In: Pediatric Pulmonology, Wiley, Vol. 58, No. 2 ( 2023-02), p. 425-432
    Abstract: Since the outbreak of the coronavirus disease 2019 (COVID‐19) pandemic, there has been a decline in pediatric emergency department visits. Our aim was to assess the pattern of pediatric foreign body aspiration (FBA) during the first year of the COVID‐19 pandemic, in comparison to the prior years. Methods In this retrospective multicenter study, we compared the number of children who presented with FBA during the COVID‐19 year (March 1, 2020 to February 28, 2021) to the annual average of the years 2016–2019. We also compared the lockdown periods to the postlockdown periods, and the percentage of missed FBA, proven FBA, and flexible bronchoscopy as the removal procedure. Results A total of 345 children with FBA from six centers were included, 276 in the pre‐COVID‐19 years (average 69 per year) and 69 in the COVID‐19 year. There was no difference in the prevalence of FBA between the COVID‐19 year and any of the prior 4 years. Examining the lockdown effect, the monthly incidence of FBA dropped from a pre‐COVID‐19 average of 5.75 cases to 5.1 cases during lockdown periods and increased to 6.3 cases in postlockdown periods. No difference in the percentage of missed FB or proven FB was observed. There was a significant rise in the usage of flexible bronchoscopy as the removal procedure (average of 15.4% vs. 30.4%, p  = 0.001). Conclusion There were fewer cases of pediatric FBA during lockdown periods, compared to post‐lockdown periods, presumably related to better parental supervision, with no difference in the prevalence of FBA during the COVID‐19 year.
    Type of Medium: Online Resource
    ISSN: 8755-6863 , 1099-0496
    URL: Issue
    URL: Article
    DOI: 10.1002/ppul.v58.2
    DOI: 10.1002/ppul.26203
    Language: English
    Publisher: Wiley
    Publication Date: 2023
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  • 6
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    The effect of inspiratory muscle training in PCD and CF patients: A pilot study
    Wiley ; 2023
    In:  Pediatric Pulmonology
    Details
    In: Pediatric Pulmonology, Wiley
    Abstract: Effective work of breathing and bronchial hygiene requires synergy of inspiratory and expiratory muscles. Inspiratory muscle training (IMT) is a part of pulmonary rehabilitation in chronic obstructive pulmonary disease (COPD). There is some evidence of its efficacy in cystic fibrosis (CF) and, recently, in long COVID‐19. We are not aware of studies on IMT in primary ciliary dyskinesia (PCD). Our aim was to assess the effect of IMT on respiratory muscle strength and pulmonary function in PCD and CF patients. Methods A single center pilot study. Spirometry, lung clearance index (LCI), maximal inspiratory pressure (MIP), and maximal expiratory pressure (MEP) were measured at baseline (visit 1), after a month of IMT with ®POWERbreathe (visit 2), and at follow‐up (visit 3). Results The cohort included 27 patients (19 PCD, 8 CF); mean age 18.4 ± 9.8 years. After a month of IMT, there was a significant increase in MIP and MIP% (6.19–7.44, p  = .015; and 81.85%–100.41%, p  = .046, respectively), which was sustained at visit 3. Compliance ≥90% led to higher improvement in MIP. In sub‐group analysis, improvement in MIP and MIP% remained significant for PCD patients ( p  = .026 and p  = .049, respectively). No significant changes were found in spirometry, MEP or LCI. Conclusions IMT was well‐tolerated and led to improved inspiratory muscle strength in PCD patients. The clinical implication of improved MIP should be further investigated. Larger, long‐term studies are needed to evaluate long‐term effects of IMT on pulmonary function, respiratory muscle strength, pulmonary exacerbations, and quality of life.
    Type of Medium: Online Resource
    ISSN: 8755-6863 , 1099-0496
    URL: Article
    DOI: 10.1002/ppul.26655
    Language: English
    Publisher: Wiley
    Publication Date: 2023
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  • 7
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    Translation of the quality of life questionnaire for primary ciliary dyskinesia (QOL‐PCD) into Hebrew: The Israeli experience
    Wiley ; 2022
    In:  Pediatric Pulmonology Vol. 57, No. 5 ( 2022-05), p. 1331-1338
    Details
    In: Pediatric Pulmonology, Wiley, Vol. 57, No. 5 ( 2022-05), p. 1331-1338
    Abstract: A primary ciliary dyskinesia (PCD) specific quality of life (QOL) questionnaire is available for English‐speaking populations. Israel has a significant number of PCD patients. We performed a translation and cultural adaptation of the QOL‐PCD questionnaire into Hebrew. The translation was validated and easily understood by patients and their parents.
    Type of Medium: Online Resource
    ISSN: 8755-6863 , 1099-0496
    URL: Issue
    URL: Article
    DOI: 10.1002/ppul.v57.5
    DOI: 10.1002/ppul.25864
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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  • 8
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    Functional capacity and quality of life in patients with vascular ring
    Wiley ; 2022
    In:  Pediatric Pulmonology Vol. 57, No. 12 ( 2022-12), p. 2946-2953
    Details
    In: Pediatric Pulmonology, Wiley, Vol. 57, No. 12 ( 2022-12), p. 2946-2953
    Abstract: Vascular rings are congenital anomalies of the aortic arch that compress the trachea and esophagus and may require corrective surgery. Data about the long‐term effects of vascular rings are scarce. We aimed to evaluate the long‐term cardiorespiratory, exercise capacity, and quality of life of vascular ring patients. Methods A single center prospective study evaluating spirometry, echocardiography, six‐minute walk test (6MWT), cardiopulmonary exercise testing (CPET), and quality of life questionnaire (SF36) in patients with a diagnosis of vascular ring, with or without corrective surgery. Results Twenty‐seven patients participated (11.9 ± 6 years, 52% males). The most common diagnosis was double aortic arch (16 patients, 59%). Nineteen patients had corrective surgery (O) and 8 did not (NO). Pulmonary function tests were within normal range in both groups (FEV 1 % predicted O = 87.6 ± 16.5, NO = 83 ± 10.8%). However, 11/27 had abnormal FEV 1 , 5 had abnormal FVC, and 13 (48%) had flattening of the expiratory curve. 6MWD and oxygen uptake were similarly mildly reduced in both groups; (6MWD O = 80.1 ± 10.7% predicted, NO = 74.1 ± 10.9% and oxygen uptake O = 78.5 ± 23.2% predicted, NO = 73.4 ± 14.3%). Peak O 2 pulse (V̇O 2 /HR% predicted) was mildly reduced in the NO group (O = 88.4 ± 17.3%, NO = 75.8 ± 16.2%). Echocardiogram and SF36 scores were normal in all patients. Conclusions Long‐term evaluation of patients born with vascular rings revealed mild pulmonary impairment, reduction in 6MWD, and oxygen uptake. The NO group had also mild reduced peak O 2 pulse. Larger, long‐term studies assessing functional parameters in operated and non‐operated patients are needed to assess disease/surgery limitation in patients with vascular rings. Clinical trial registration number: NCT04781738.
    Type of Medium: Online Resource
    ISSN: 8755-6863 , 1099-0496
    URL: Issue
    URL: Article
    DOI: 10.1002/ppul.v57.12
    DOI: 10.1002/ppul.26112
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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  • 9
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    Intractable cough in a preterm infant with ventriculoperitoneal shunt
    Wiley ; 2013
    In:  Pediatric Pulmonology Vol. 48, No. 4 ( 2013-04), p. 405-407
    Details
    In: Pediatric Pulmonology, Wiley, Vol. 48, No. 4 ( 2013-04), p. 405-407
    Abstract: We describe the case of an 8‐month‐old preterm female with a ventriculoperitoneal (VP) shunt who had an intractable resistant cough of three months duration without any identifiable cause. Reposition of the abdominal part of the VP shunt resulted in an immediate and lasting resolution of the cough. This is the first case report describing an infradiaphragmatic irritation as an etiology for persistent cough with ultimate resolution upon reposition of the shunt. Pediatr Pulmonol. 2013; 48:405–407. © 2012 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 8755-6863 , 1099-0496
    URL: Issue
    URL: Article
    DOI: 10.1002/ppul.v48.4
    DOI: 10.1002/ppul.22596
    Language: English
    Publisher: Wiley
    Publication Date: 2013
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  • 10
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    Cardiopulmonary exercise test to quantify enzyme replacement response in pediatric Pompe disease
    Wiley ; 2018
    In:  Pediatric Pulmonology Vol. 53, No. 3 ( 2018-03), p. 366-373
    Details
    In: Pediatric Pulmonology, Wiley, Vol. 53, No. 3 ( 2018-03), p. 366-373
    Abstract: Enzyme replacement therapy (ERT) with Myozyme improved the prospect of Pompe disease patients. Our aim was to evaluate ERT acute effect on exercise capacity in pediatric Pompe patients. Methods Five Pompe patients (10‐19 years, 4 infantile‐onset and 1 diagnosed at 5 years) were evaluated before and 2 days after ERT using cardiopulmonary exercise testing (CPET), 6 min walking test (6MWT) and motor function test (GMFM‐88). Results Preserved normal peak oxygen uptake, 6MWT and motor function were observed in the relative mild disease and impairment of these parameters in the more advanced disease. Two days following ERT, three patients demonstrated changes; one patient (relative mild disease) increased both oxygen uptake (11%) and walking distance (38%). Second patient (advanced disease) increased oxygen uptake (11%) while a small decrease in walking distance in the 6MWT (8%) was observed. Third patient (advanced disease) decreased oxygen uptake (39%) but increased walking distance (42%) and motor function score (27%). Conclusions CPET is safe for pediatric Pompe patients. ERT may benefit exercise capacity in patients with less advanced disease. Individualized assessment by CPET, 6MWT, and motor function may help ERT adjustment by providing precise quantification of the response to treatment. Additional studies are needed to clarify the benefit of this assessment protocol.
    Type of Medium: Online Resource
    ISSN: 8755-6863 , 1099-0496
    URL: Issue
    URL: Article
    DOI: 10.1002/ppul.v53.3
    DOI: 10.1002/ppul.23830
    Language: English
    Publisher: Wiley
    Publication Date: 2018
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