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  • 1
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2024
    In:  Parasites & Vectors Vol. 17, No. 1 ( 2024-03-06)
    In: Parasites & Vectors, Springer Science and Business Media LLC, Vol. 17, No. 1 ( 2024-03-06)
    Abstract: Schistosomiasis, a neglected tropical disease, remains an important public health problem. Although there are various methods for diagnosing schistosomiasis, many limitations still exist. Early diagnosis and treatment of schistosomiasis can significantly improve survival and prognosis of patients. Methodology Circulating cell-free (cf)DNA has been widely used in the diagnosis of various diseases. In our study, we evaluated the diagnostic value of circulating cfDNA for schistosomiasis caused by Schistosoma japonicum . We focused on the tandem sequences and mitochondrial genes of S. japonicum to identify highly sensitive and specific targets for diagnosis of Schistosomiasis japonica . Results Through data screening and analysis, we ultimately identified four specific tandem sequences ( TD-1 , TD-2 , TD-3 . and TD-4 ) and six mitochondrial genes ( COX1(1) , COX1(2) , CYTB , ATP6 , COX3 , and ND5 ). We designed specific primers to detect the amount of circulating cfDNA in S. japonicum -infected mouse and chronic schistosomiasis patients. Our results showed that the number of tandem sequences was significantly higher than that of the mitochondrial genes. A S. japonicum infection model in mice suggested that infection of S. japonicum can be diagnosed by detecting circulating cfDNA as early as the first week. We measured the expression levels of circulating cfDNA ( TD-1 , TD-2 , and TD-3 ) at different time points and found that TD-3 expression was significantly higher than that of TD-1 or TD-2 . We also infected mice with different quantities of cercariae (20 s and 80 s). The level of cfDNA ( TD-3 ) in the 80 s infection group was significantly higher than in the 20 s infection group. Additionally, cfDNA ( TD-3 ) levels increased after egg deposition. Meanwhile, we tested 42 patients with chronic Schistosomiasis japonica and circulating cfDNA ( TD-3 ) was detected in nine patients. Conclusions We have screened highly sensitive targets for the diagnosis of Schistosomiasis japonica , and the detection of circulating cfDNA is a rapid and effective method for the diagnosis of Schistosomiasis japonica . The levels of cfDNA is correlated with cercariae infection severity. Early detection and diagnosis of schistosomiasis is crucial for patient treatment and improving prognosis. Graphical Abstract
    Type of Medium: Online Resource
    ISSN: 1756-3305
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2024
    detail.hit.zdb_id: 2409480-8
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  • 2
    In: Energy & Environmental Science, Royal Society of Chemistry (RSC), Vol. 16, No. 4 ( 2023), p. 1540-1547
    Abstract: Due to the large size and heavy mass of the K-ion, the pursuit of reliable anodes with outstanding comprehensive performance for K-ion batteries (KIBs) remains a formidable challenge. Typically, high-capacity potassium storage will lead to the electrodes’ serious volumetric expansion and elevated instability. Herein, it is identified that a single-atomic sulfur composite can act as a high-performance KIB anode with an excellent combination of capacity, cyclability, and rate. A high content (∼32 wt%) single-atomic sulfur can be covalently bonded into the carbon lattice of multi-shelled hollow nanospheres via a simple low-temperature pyrolyzation of the selected precursor. The superb redox reactivity of the single-atomic sulfur together with the porous architectures for the resultant S/C composite can not only enable a fast surface-dominated potassium storage but also ensure its structural resilience, thereby achieving high specific capacity together with outstanding rate and impressive cyclability. This study envisions new perspectives on designing high-performance sulfur-based electrodes.
    Type of Medium: Online Resource
    ISSN: 1754-5692 , 1754-5706
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 2439879-2
    detail.hit.zdb_id: 2448515-9
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  • 3
    Online Resource
    Online Resource
    AME Publishing Company ; 2020
    In:  Quantitative Imaging in Medicine and Surgery Vol. 10, No. 5 ( 2020-5), p. 1138-1140
    In: Quantitative Imaging in Medicine and Surgery, AME Publishing Company, Vol. 10, No. 5 ( 2020-5), p. 1138-1140
    Type of Medium: Online Resource
    ISSN: 2223-4292 , 2223-4306
    Language: Unknown
    Publisher: AME Publishing Company
    Publication Date: 2020
    detail.hit.zdb_id: 2653586-5
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  • 4
    Online Resource
    Online Resource
    Frontiers Media SA ; 2019
    In:  Frontiers in Plant Science Vol. 10 ( 2019-6-4)
    In: Frontiers in Plant Science, Frontiers Media SA, Vol. 10 ( 2019-6-4)
    Type of Medium: Online Resource
    ISSN: 1664-462X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2019
    detail.hit.zdb_id: 2613694-6
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  • 5
    Online Resource
    Online Resource
    Royal Society of Chemistry (RSC) ; 2021
    In:  Journal of Materials Chemistry A Vol. 9, No. 8 ( 2021), p. 4589-4625
    In: Journal of Materials Chemistry A, Royal Society of Chemistry (RSC), Vol. 9, No. 8 ( 2021), p. 4589-4625
    Type of Medium: Online Resource
    ISSN: 2050-7488 , 2050-7496
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2021
    detail.hit.zdb_id: 2702232-8
    detail.hit.zdb_id: 2696984-1
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  • 6
    Online Resource
    Online Resource
    IOP Publishing ; 2024
    In:  Journal of Physics: Conference Series Vol. 2808, No. 1 ( 2024-07-01), p. 012043-
    In: Journal of Physics: Conference Series, IOP Publishing, Vol. 2808, No. 1 ( 2024-07-01), p. 012043-
    Abstract: At present, the traditional welding temperature field and stress prediction mainly rely on the experience curve or empirical formula based on experiment and statistics, which cannot comprehensively predict and analyze the impact of welding on the overall structural mechanical characteristics and objectively evaluate the welding quality. In this paper, based on simulated welding software, the temperature field stress field and residual stress deformation after welding are simulated by the finite element method, and a set of feasible 3D welding temperature field calculation methods, stress field, and deformation dynamic simulation analysis methods are established.
    Type of Medium: Online Resource
    ISSN: 1742-6588 , 1742-6596
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2024
    detail.hit.zdb_id: 2166409-2
    detail.hit.zdb_id: 2209069-1
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  • 7
    Online Resource
    Online Resource
    American Chemical Society (ACS) ; 2020
    In:  ACS Applied Materials & Interfaces Vol. 12, No. 44 ( 2020-11-04), p. 49297-49322
    In: ACS Applied Materials & Interfaces, American Chemical Society (ACS), Vol. 12, No. 44 ( 2020-11-04), p. 49297-49322
    Type of Medium: Online Resource
    ISSN: 1944-8244 , 1944-8252
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2020
    detail.hit.zdb_id: 2492276-6
    detail.hit.zdb_id: 2467494-1
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  • 8
    Online Resource
    Online Resource
    JMIR Publications Inc. ; 2020
    In:  JMIR Formative Research Vol. 4, No. 8 ( 2020-8-5), p. e16422-
    In: JMIR Formative Research, JMIR Publications Inc., Vol. 4, No. 8 ( 2020-8-5), p. e16422-
    Abstract: In many research studies, the identification of social determinants is an important activity, in particular, information about occupations is frequently added to existing patient data. Such information is usually solicited during interviews with open-ended questions such as “What is your job?” and “What industry sector do you work in?” Before being able to use this information for further analysis, the responses need to be categorized using a coding system, such as the Canadian National Occupational Classification (NOC). Manual coding is the usual method, which is a time-consuming and error-prone activity, suitable for automation. Objective This study aims to facilitate automated coding by introducing a rigorous algorithm that will be able to identify the NOC (2016) codes using only job title and industry information as input. Using manually coded data sets, we sought to benchmark and iteratively improve the performance of the algorithm. Methods We developed the ACA-NOC algorithm based on the NOC (2016), which allowed users to match NOC codes with job and industry titles. We employed several different search strategies in the ACA-NOC algorithm to find the best match, including exact search, minor exact search, like search, near (same order) search, near (different order) search, any search, and weak match search. In addition, a filtering step based on the hierarchical structure of the NOC data was applied to the algorithm to select the best matching codes. Results The ACA-NOC was applied to over 500 manually coded job and industry titles. The accuracy rate at the four-digit NOC code level was 58.7% (332/566) and improved when broader job categories were considered (65.0% at the three-digit NOC code level, 72.3% at the two-digit NOC code level, and 81.6% at the one-digit NOC code level). Conclusions The ACA-NOC is a rigorous algorithm for automatically coding the Canadian NOC system and has been evaluated using real-world data. It allows researchers to code moderate-sized data sets with occupation in a timely and cost-efficient manner such that further analytics are possible. Initial assessments indicate that it has state-of-the-art performance and is readily extensible upon further benchmarking on larger data sets.
    Type of Medium: Online Resource
    ISSN: 2561-326X
    Language: English
    Publisher: JMIR Publications Inc.
    Publication Date: 2020
    detail.hit.zdb_id: 2941716-8
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