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  • 1
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    High in-hospital blood pressure variability and severe disability or death in primary intracerebral hemorrhage patients
    SAGE Publications ; 2019
    In:  International Journal of Stroke Vol. 14, No. 9 ( 2019-12), p. 987-995
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 14, No. 9 ( 2019-12), p. 987-995
    Abstract: To quantify in-hospital systolic blood pressure variability among patients with intracerebral hemorrhage, determine the association between high systolic blood pressure variability (HSBPV) and 90-day severe disability or death, and examine the association between pre-hospital factors and HSBPV. Methods Adult, radiologically confirmed, intracerebral hemorrhage patients enrolled in a multi-site cohort were included. Using a semi-automated algorithm, systolic blood pressure values recorded from routine non-invasive systolic blood pressure monitoring in critical and acute care settings were extracted for the duration of hospitalization. Inter and intra-patient systolic blood pressure variability was quantified using generalized estimating equation methods. Modified Poisson and logistic regression models were fit to determine the association between HSBPV and 90-day severe disability or death and between pre-hospital characteristics and HSBPV, respectively. Results A total of 566 patients managed at four certified stroke centers were included. Over 120,000 systolic blood pressure readings were analyzed, and a standard deviation (SD) of 13.0 was parameterized as a cut-off point to categorize HSBPV. Patients with HSBPV had a greater risk of 90-day severe disability or death (relative risk: 1.20, 95% confidence interval: 1.04–1.39), after controlling for age, pre-morbid functional status, and other disease severity measures. Greater likelihood of in-hospital HSBPV was independently observed in elderly, female patients, and in patients with high admission systolic blood pressure. Conclusion Quantification of HSBPV is feasible utilizing routinely collected systolic blood pressure readings, and a singular cut-off parameter for systolic blood pressure variability demonstrated association with 90-day severe disability or death. Elderly, female, and patients with high admission systolic blood pressure may be more likely to demonstrate HSBPV during hospitalization.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/1747493019827763
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2211666-7
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  • 2
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    Abstract TMP73: Rehabilitation for Patients With Primary Intracerebral Hemorrhage is Associated With Reduced 30-Day Hospital Readmissions
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Stroke Vol. 49, No. Suppl_1 ( 2018-01-22)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 49, No. Suppl_1 ( 2018-01-22)
    Abstract: Introduction: Readmission (RA) after stroke is an established quality of care metric and is tied to reimbursements. Administrative databases lack stroke-specific severity indicators and information on post-discharge mortality. We report the cumulative incidence of 30-day RA for patients with primary intracerebral hemorrhage (ICH) from a statewide prospective cohort. Methods: Eligible ICH patients are consented to participate in the cohort to assess the impact of level of care on patient-centered outcomes across Texas. Patients undergo inpatient evaluation, followed by 30- and 90-day assessments for functional, cognitive, quality of life, dependency, and resource utilization outcomes. We defined 30-day RA as any RA that was assessed 30 days post-acute care hospitalization for the index ICH event. We used survival analyses to provide hazard ratios (HR) and 95% confidence interval (CI), while modeling post-discharge mortality as a competing risk. Results: Thus far, 158 patients have been enrolled with RA information available for 104. The overall RA rate is 5.1 / 1000 person-days (CI: 3.1-8.3). Among the various factors evaluated (Table 1), 30-day RA is significantly higher for patients with a higher ICH score (HR: 5.67, CI: 1.45-22.19), whereas post-discharge rehabilitation (as compared to discharge to home) appears to reduce the risk of RA, even after accounting for institution-free period of observation (HR: 0.11, CI: 0.01-0.86). Among patients with a high ICH score, those discharged home had significantly higher risk of RA as compared to those who received rehabilitation (Figure 1). Enrollment is continuing; updated analyses will be presented. Conclusion: Stroke-specific disease severity factors are important to identify to develop effective preventive strategies against RA, and need to be controlled for when comparing RA metrics across patient populations. Influence of post-stroke rehab on curtailing RA for ICH patients needs to be explored further.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.49.suppl_1.TMP73
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 1467823-8
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  • 3
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    Abstract TP339: Utilization of Comprehensive Stroke Center Services for Patients With Primary Intracerebral Hemorrhage
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Stroke Vol. 49, No. Suppl_1 ( 2018-01-22)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 49, No. Suppl_1 ( 2018-01-22)
    Abstract: Introduction: Intracerebral hemorrhage (ICH) patients are routinely transferred to comprehensive stroke centers (CSCs) for neurosurgical and neurocritical care. We compared transferred (TP) and directly presenting (DP) ICH patients at our CSC, and explore the factors associated with non-utilization of CSC Services (NCS). Methods: We identified primary ICH patients, admitted between 01/01/2016 and 03/31/2017, from our Stroke Registry. We used logistic regression to compare demographics, disease severity, and outcomes between TP and DP, and report odds ratios (OR) and 95% confidence intervals (CI). We categorized patients who did not stay in the neurocritical care unit and did not undergo neurosurgical procedures (including extra-ventricular drain) as NCS patients. We used receiver operative curve (ROC) analyses to determine the discriminatory potential of routinely used severity scales in identifying NCS patients and report area under the curve (AUC). Results: We included 958 patients in our analyses. TP had significantly lower disease severity and shorter length of stay. Overall, 33.7% of patients were NCS, and NCS patients were more likely to be TP as compared to DP [OR (CI): 1.60 (1.18-2.16)]. NCS patients also had a significantly lower median National Institutes of Health Stroke Scale (NIHSS) and ICH scores, and higher median Glasgow Coma Scale (GCS) score on presentation (Table 1). All three scales had a fair-good individual discrimination for classifying NCS patients (AUC for GCS, NIHSS, ICH Score: 0.71, 0.77, and 0.80 respectively). After dichotomizing GCS at 10 and categorizing NIHSS at 0-5 / 6-15 / 16+, the combined AUC for all three scales was 0.84 (Figure 1). Conclusion: A third of ICH patients presenting at CSC do not utilize neurosurgical / neurocritical care. Identification and triage of these patients may help optimize ICH care. Disease severity scales may be helpful in classification of these patients. Further validation studies are warranted.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.49.suppl_1.TP339
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
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  • 4
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    Risk of intracranial hemorrhage associated with pregnancy in women with cerebral arteriovenous malformations
    BMJ ; 2021
    In:  Journal of NeuroInterventional Surgery Vol. 13, No. 8 ( 2021-08), p. 707-710
    Details
    In: Journal of NeuroInterventional Surgery, BMJ, Vol. 13, No. 8 ( 2021-08), p. 707-710
    Abstract: Prior studies on rupture risk of brain arteriovenous malformations (AVMs) in women undergoing pregnancy and delivery have reported conflicting findings, but also have not accounted for AVM morphology and heterogeneity. Here, we assess the association between pregnancy and the risk of intracranial hemorrhage (ICH) in women with AVMs using a cohort-crossover design in which each woman serves as her own control. Methods Women who underwent pregnancy and delivery were identified using DRG codes from the Healthcare Cost and Utilization Project State Inpatient Databases for California (2005–2011), Florida (2005–2014), and New York (2005–2014). The presence of AVM and ICH was determined using ICD 9 codes. Pregnancy was defined as the 40 weeks prior to delivery, and postpartum as 12 weeks after. We defined a non-exposure control period as a 52-week period prior to pregnancy. The relative risks of ICH during pregnancy were compared against the non-exposure period using conditional Poisson regression. Results Among 4 022 811 women identified with an eligible delivery hospitalization (median age, 28 years; 7.3% with gestational diabetes; 4.5% with preeclampsia/eclampsia), 568 (0.014%) had an AVM. The rates of ICH during pregnancy and puerperium were 6355.4 (95% CI 4279.4 to 8431.5) and 14.4 (95% CI 13.3 to 15.6) per 100 000 person-years for women with and without AVM, respectively. In cohort-crossover analysis, in women with AVMs the risk of ICH increased 3.27-fold (RR, 95% CI 1.67 to 6.43) during pregnancy and puerperium compared with a non-pregnant period. Conclusions Among women with AVM, pregnancy and puerperium were associated with a greater than 3-fold risk of ICH.
    Type of Medium: Online Resource
    ISSN: 1759-8478 , 1759-8486
    URL: Article
    DOI: 10.1136/neurintsurg-2020-016838
    Language: English
    Publisher: BMJ
    Publication Date: 2021
    detail.hit.zdb_id: 2506028-4
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  • 5
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    Direct Assessment of Health Utilities Using the Standard Gamble Among Patients With Primary Intracerebral Hemorrhage
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Circulation: Cardiovascular Quality and Outcomes Vol. 12, No. 9 ( 2019-09)
    Details
    In: Circulation: Cardiovascular Quality and Outcomes, Ovid Technologies (Wolters Kluwer Health), Vol. 12, No. 9 ( 2019-09)
    Abstract: Standard gamble (SG) directly measures patients’ valuation of their health state. We compare in-hospital and day-90 SG utilities (SGU) among intracerebral hemorrhage patients and report a 3-way association between SGU, EuroQoL-5 dimension, and modified Rankin Scale at day 90. Methods and Results: Patients with intracerebral hemorrhage underwent in-hospital and day-90 assessments for the modified Rankin Scale, EuroQoL-5 dimension, and SG. SG provides patients a choice between their current health state and a hypothetical treatment with varying chances of either perfect health or a painless death. Higher SGU (scale, 0–1) indicates lower risk tolerance and thus higher valuation of the current health state. Logistic regression was used to estimate the likelihood of low SGU (≤0.6), and Wilcoxon paired signed-rank test compared in-hospital and day-90 SGU. In-hospital and day-90 SG was obtained from 381 and 280 patients, respectively, including 236 paired observations. Median (interquartile range) in-hospital and day-90 SGUs were 0.85 (0.40–0.98) and 0.98 (0.75–1.00; P 〈 0.001). In-hospital SGUs were lower with advancing age ( P =0.007), higher National Institutes of Health Stroke Scale, and intracerebral hemorrhage scores ( P 〈 0.001). Proxy-based assessments resulted in lower SGUs; median difference (95% CI), −0.2 (−0.33 to −0.07). After adjustment, higher National Institutes of Health Stroke Scale and proxy assessments were independently associated with lower SGU, along with an effect modification of age by race. Day-90 SGU and modified Rankin Scale were significantly correlated; however, SGUs were higher than the EuroQoL-5 dimension utilities at higher modified Rankin Scale levels. Conclusions: Divergence between directly (SGU) and indirectly (EuroQoL-5 dimension) assessed utilities at high levels of functional disability warrant careful prognostication of intracerebral hemorrhage outcomes and should be considered in designing early end-of-life care discussions with families and patients.
    Type of Medium: Online Resource
    ISSN: 1941-7713 , 1941-7705
    URL: Article
    DOI: 10.1161/CIRCOUTCOMES.119.005606
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2453882-6
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  • 6
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    Abstract 026: High In-Hospital Systolic Blood Pressure Variability and Poor Functional Outcomes in Primary Intracerebral Hemorrhage Patients
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Hypertension Vol. 72, No. Suppl_1 ( 2018-09)
    Details
    In: Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 72, No. Suppl_1 ( 2018-09)
    Abstract: Introduction: High in-hospital SBP variability (HSBPV) is an emerging marker for poor outcomes among Intracerebral Hemorrhage (ICH) patients. We aimed to determine the risk of severe disability or death (SDD) at day-90 among ICH patients with HSPBV and explore pre-hospital factors associated with HSPBV. Methods: Adult, radiologically confirmed primary ICH patients were prospectively enrolled and followed-up until day-90. All routinely collected SBP values were recorded for the inpatient stay. Inter and intra-patient SBPV was quantified using generalized estimating equations. Modified Rankin Scale (mRS) Score of 4 - 6 was defined as SDD. Poisson and logistic regression models were fit to determine the risk of day-90 SDD, and the association of pre-hospital characteristics with HSBPV. Results: A total of 566 patients [mean age: 63.5, females 36.6% (207 of 566)] were included. Total in-hospital follow-up period was 4,908 days [median (IQR) per patient = 8.7 (3-11)] . Over 120,500 SBP readings were analyzed. Inter and intra-patient mean SBP standard deviation (SD) was 11.1 and 13.2, respectively. A SD of 13.0 was parameterized as a cut-off for HSBPV. HSBPV patients had a 17% higher adjusted risk of day-90 SDD (Relative Risk, 95% CI: 1.17, 1.02-1.35) (Table). Older age and female sex were independently associated with HSBPV after controlling for hemorrhage volume, pre-morbid mRS, and Glasgow Coma Scale (Figure). Conclusion: Quantification of HSBPV is feasible utilizing routinely collected SBP readings. HSBPV is associated with poor outcomes. Elderly and female patients may be more likely to demonstrate HSBPV during hospitalization.
    Type of Medium: Online Resource
    ISSN: 0194-911X , 1524-4563
    URL: Article
    DOI: 10.1161/hyp.72.suppl_1.026
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 2094210-2
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  • 7
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    Abstract WP334: In-hospital Systolic Blood Pressure Variability in Elderly Patients With Primary Intracerebral Hemorrhage
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Stroke Vol. 49, No. Suppl_1 ( 2018-01-22)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 49, No. Suppl_1 ( 2018-01-22)
    Abstract: Introduction: Systolic blood pressure (SBP) regulation is the cornerstone of intracerebral hemorrhage (ICH) management, and SBP variability (SBPV) is associated with poor outcomes. We aimed to determine SBPV patterns and associated factors in a prospective cohort of ICH patients. Methods: Primary ICH patients are consented, assessed in-hospital and followed up at 30 and 90 days. All SBP values and BP management details for the hospital stay were collected from electronic medical records. Day and night intervals were defined as 0601 - 2159hrs and 2200 - 0600hrs, respectively. Mean and standard deviation (SD) were calculated for all intervals in each patient. Overall, between and within patient SBPV for day and night was characterized by generalized estimating equation (GEE)-based methods. We identified patients with a high SBPV (HSBPV) and built logistic regression models to determine associated factors. Results: Thus far, 158 patients have been enrolled, with detailed SBP data was available for 126. Total in-hospital follow-up period is 1,446 days [Median (IQR): 8 (4.25 - 15)]. We analyzed 34,740 SBP readings, yielding 3,010 day/night intervals. The in-hospital mean (SD) SBP was 138.2 (15.6) mmHg. GEE-based estimates for mean night SBP were significantly lower compared to day (137.2 v 139.1 mmHg, p 〈 0.01). Mean SBP SD was 9.1 mmHg between patients while 13.4 mmHg within patients’ individual readings. HSBPV was defined as SD 〉 13 mmHg. Age and high admission SBP were independently associated with HSBPV after controlling for sex, race, admission NIHSS, ICH score, hemorrhage volume and Nicardipine infusion use (Figure). Enrollments are continuing and updated data with outcomes will be presented. Conclusion: Characterization of patients with HSBPV can help in triage and management decisions based on risk-stratification. Elderly patients may be at a higher risk of SBPV, warranting exploration of possible SBPV contribution to poor outcomes in the elderly.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.49.suppl_1.WP334
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
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  • 8
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    Abstract 166: Spleen Contraction in Patients With Ischemic Stroke and Brain Hemorrhage: Validating Animal Studies
    Ovid Technologies (Wolters Kluwer Health) ; 2015
    In:  Stroke Vol. 46, No. suppl_1 ( 2015-02)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 46, No. suppl_1 ( 2015-02)
    Abstract: Objectives: Animal models have shown that the spleen contracts and contributes to post-ischemic inflammation that may exacerbate brain injury and impair recovery. Translation of these findings in patients is challenging because of a lack of normative spleen volume (SV) data. We created normograms of SV for an adult at-risk population, quantified splenic contraction (SC) in stroke patients, and characterized patients with SC. Methods: We enrolled 158 healthy volunteers (HV) with matching age and gender distribution with that of our stroke center registry. Spleen ultrasounds were performed on 5 consecutive days. We used quantile regression models to identify predictors of SV for HV. Gender and body surface area (BSA) were used to construct percentile based normograms of SV, and the expected pre-stroke SV were calculated, from which SC was quantified. We also enrolled a cohort of 170 patients with acute stroke and intracerebral hemorrhage within 24 hours of symptom onset and performed serial spleen ultrasound measurements during hospitalization. Logistic regression was used to determine factors associated with SC. Results: Normograms for SV in healthy males and females based on BSA were created (Figure 1). Over a 5-day consecutive period of daily spleen measurements, the maximum day to day variation was 10.6 cm3. Based on these findings, stroke patients with a normalized SV below 20 cm3 of their expected SV, were classified as having SC. Excluding stroke mimics, 158 patients were included in the analyses, of which 64 (40.5%) had SC detected within 24 hrs of symptom onset. African-American race, older age, and history of previous stroke were significantly associated with SC (Table 1). Conclusion: The spleen does appear to reduce in size after stroke in some specific subgroups of patients with acute stroke and brain hemorrhage. The biological relevance of SC to the inflammatory response and functional outcomes of stroke patients are currently being studied in our study cohorts.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.46.suppl_1.166
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2015
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  • 9
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    Abstract TP276: Health-Related Quality of Life Indices for Patients with Primary Intracerebral Hemorrhage
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Stroke Vol. 49, No. Suppl_1 ( 2018-01-22)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 49, No. Suppl_1 ( 2018-01-22)
    Abstract: Introduction: Assessments of health-related quality of life (QoL) are increasingly important for stroke patients; however, such data are lacking for patients with intracerebral hemorrhage (ICH). Using EuroQol-5 Dimension-5 Level (EQ5D), we describe factors associated with QoL, and explore associations between QoL and functional outcomes in ICH patients. Methods: Our study is a multisite prospective cohort aiming to examine comparative effectiveness of treating ICH patients at various levels of care across Texas. Consented patients undergo QoL assessments - including EQ5D - in-hospital and 90 days post-discharge. EQ5D health utility values (HUV) were calculated using published utility weights for US population. HUVs range from -0.11 to 1.00, with 0.00 and 1.00 representing patient-perceived QoL equivalent to death and perfect health, respectively. Median and interquartile range (IQR) are reported. Quantile regression was used to evaluate factors associated with HUVs, and we report difference in median (DIM) and 95% confidence interval (CI) for the difference. Results: Thus far 158 patients have been enrolled in the study. EQ5D HUVs were obtained from 133 patients in-hospital and 62 patients at day 90. Median in-hospital and day-90 HUVs were significantly lower for patients with higher NIHSS and ICH scores. Patients with in-hospital complications, neurosurgical procedures, and longer length of stay also had lower HUVs (Table 1). There was a significant improvement in HUVs during 90-days post-discharge (DIM: 0.37; 95% CI: 0.24-0.51), and high day-90 HUVs were associated with good functional outcome (mRS 0-3) (Figure 1, DIM: 0.65, 95% CI: 0.51-0.78, p 〈 0.001). Enrollment continues; updated analyses to be presented. Conclusion: Our results indicate a correlation between QoL, and inpatient clinical parameters and functional outcomes. Assessment of QoL may be routinely conducted in ICH studies to generate evidence for comparative effectiveness.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.49.suppl_1.TP276
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 1467823-8
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  • 10
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    Abstract TMP76: Direct Assessment of Health Utilities Among Patients With Intracerebral Hemorrhage Using the Standard Gamble Method
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Stroke Vol. 50, No. Suppl_1 ( 2019-02)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 50, No. Suppl_1 ( 2019-02)
    Abstract: Introduction: EuroQoL-5 Dimension (EQ-5D) is a validated albeit indirect method to derive health utilities (HU). Conversely, Standard Gamble (SG) directly measures patients’ valuation of their health state. We compare in-hospital and day-90 SG Utilities (SGU) among intracerebral hemorrhage (ICH) patients and report a three-way association between SGU, EQ-5D and mRS at day-90. Methods: Primary ICH patients were enrolled in a multisite cohort and underwent in-hospital and day-90 assessments for the mRS, EQ-5D, and SG. SG entails providing patients a choice between their current health state and a hypothetical treatment (a pill) with varying chances of either perfect health or a painless death. Higher SGU (scale 0 - 1) indicates a lower risk-tolerance for death; thus, a higher valuation of one’s health state. Median and interquartile range (IQR) are reported. Logistic regression was used to estimate the likelihood of low SGU (≤ 0.6) and Wilcoxson paired signed rank test compared in-hospital and day-90 SGU. Results: In-hospital and day-90 SG was obtained from 381 and 280 patients respectively (including 236 paired observations). Median (IQR) in-hospital and day-90SGU were 0.85 (0.40-0.98) and 0.98 (0.75-1.00) (p 〈 0.001). In-hospital SGU were lower with advancing age (p = 0.007), with higher NIHSS and ICH scores (p 〈 0.001), and with greater treatment intensity. Proxies evaluated lower SGU (p 〈 0.001). In the adjustedmodel, higher NIHSS and proxy assessments were independently associated with lower SGU, along with an interaction between age and SGU by race (white vs. black) (Figure). Day-90 SGU and mRS were correlated (p 〈 0.001), however SGU were increasinglyhigher than the EQ-5D HU at higher mRS scores (Figure). Conclusion: Divergence between directly and in-directly assessed HU at high levels of functional disability warrant careful prognostication of ICH outcomes, and should be considered in designing early end-of-life care discussions with families and patients.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.50.suppl_1.TMP76
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 1467823-8
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