In:
Pediatric Blood & Cancer, Wiley, Vol. 50, No. 5 ( 2008-05), p. 1065-1067
Abstract:
Hematopoetic stem cell transplantation, even from an HLA 6/6 identical family member is associated with an increased frequency of complication in fanconi anemia (FA). The increased susceptibility for chromosomal breaks has been suggested as a contributory factor for increased risk of toxicity, graft versus host disease (GVHD) and increased incidence of post‐transplant solid tumors. Therefore, non‐irradiation based preparative regimens usually containing fludarabine and T‐cell depletion of HLA geno‐identical bone marrow cells have increasingly been used in patients with FA. Here, we report three children with FA who underwent CD‐34 selected HSCT from HLA‐identical family donors with reduced intensity fludarabine‐based regimen. Pediatr Blood Cancer 2008;50:1065–1067. © 2007 Wiley‐Liss, Inc.
Type of Medium:
Online Resource
ISSN:
1545-5009
,
1545-5017
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
2130978-4
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