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  • 1
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    Online Resource
    Successive waves of COVID 19: confinement effects on virus-prevalence with a mathematical model
    Springer Science and Business Media LLC ; 2021
    In:  European Journal of Medical Research Vol. 26, No. 1 ( 2021-12)
    Details
    In: European Journal of Medical Research, Springer Science and Business Media LLC, Vol. 26, No. 1 ( 2021-12)
    Abstract: A pandemic outbreak of severe acute respiratory syndrome coronavirus 2 (COVID 19) incidence data are largely available online. Until August 17, COVID 19 has hit more than 22 million individuals all over the globe. So, it is urged to get clear information about the prevalence of the virus. Therefore, one can manipulate easily a suitable mathematical model to fit these published data. Methods We propose a mathematical model that considers the total population, in 25 countries, either infected by COVID 19 or confined (safe) during the period from November 17, 2019, to August 17, 2020. The model considers the total population as a complex number; the imaginary part is the number of infected individuals and the real part is the number of confined individuals. This classification combined with mathematical treatments leads to a transmission dynamics of the virus to be as wave-like motion. The virus can hit any country either by one wave or by successive waves (up to 11 waves). Findings We find net discrimination between the 25 countries investigated in this report. The immediate response to the first attack is a substantial parameter to determine whether the epidemic attack will be in one wave or it can be in successive waves. For example, the best case was such as individuals in China hit by one wave while the individuals in the USA were attacked by nine waves; it is the worst case all over the globe. In addition, the model differentiates between the daily reproduction numbers ( R d0 ) and the median reproduction number ( R 0 ). We have found that R d0 decreases exponentially with time from high values down to zero at the wave maximum point; and R 0 varies from a country to another. For example, the virus hit individuals in Germany in R 0  = 1.39 (96% CI 1.01–3.87) and in the USA R 0  = 3.81 (91% CI 1.71–5.15). We have found that twice the virus has hit both the USA and Iran. The great protestation of black matter lives in the USA and the great assemblage of the new Iranian year, on March 21, 2020, have been the cause of the second epidemic attack in both countries. Interpretation Our results show that COVID 19 transmission depends on the prompt reaction against the first viral-wave. The reaction depends on both the social behaviour of individuals and on the swift system-decision by the governmental decision-maker(s). The Chinese strictly follow the decision-maker and therefore the virus hit by only one wave; while in the USA, the system-decision was different and the American-responses were different, therefore ten waves followed the first wave.
    Type of Medium: Online Resource
    ISSN: 2047-783X
    URL: Article
    DOI: 10.1186/s40001-021-00596-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2129989-4
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  • 2
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    Neuroprotective effect of liraglutide and memantine in a rat model of Alzheimer’s disease
    Medknow ; 2024
    In:  Asian Pacific Journal of Tropical Biomedicine Vol. 14, No. 5 ( 2024-05), p. 207-214
    Details
    In: Asian Pacific Journal of Tropical Biomedicine, Medknow, Vol. 14, No. 5 ( 2024-05), p. 207-214
    Abstract: To assess the effect of memantine combined with liraglutide on aluminum chloride (AlCl 3 ) and D -galactose ( D -GAL)- induced neurotoxicity in rats. Methods: Male Wistar rats were divided into 5 groups of 5 animals each: the positive control, the negative control, the memantine-treated group, the liraglutide-treated group, and the combination group treated with memantine and liraglutide. AlCl 3 and D -GAL were used to induce neurotoxicity. Behavioral tests, brain beta-amyloid protein, and oxidative stress biomarkers were evaluated. Results: The Morris water maze test indicated an enhanced memory in the combination group. Moreover, the combination treatment of liraglutide and memantine resulted in a remarkable reduction in the beta-amyloid protein level in the brain tissue. Neuronal inflammation and oxidative stress biomarkers were significantly reduced, and the levels of antioxidant parameters were enhanced. Conclusions: The combination of liraglutide and memantine exerts neuroprotective effects and enhances memory and cognitive functions in rats with Alzheimer’s disease.
    Type of Medium: Online Resource
    ISSN: 2221-1691 , 2588-9222
    URL: Article
    DOI: 10.4103/apjtb.apjtb_937_23
    Language: English
    Publisher: Medknow
    Publication Date: 2024
    detail.hit.zdb_id: 2648523-0
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  • 3
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    Inhibin-Positive “Cholangioblastic” Variant of Intrahepatic Cholangiocarcinoma: Report of 3 New Patients With Review of the Literature
    SAGE Publications ; 2023
    In:  International Journal of Surgical Pathology Vol. 31, No. 8 ( 2023-12), p. 1495-1504
    Details
    In: International Journal of Surgical Pathology, SAGE Publications, Vol. 31, No. 8 ( 2023-12), p. 1495-1504
    Abstract: Cholangiocarcinoma is the second most common primary liver malignant neoplasm. It usually affects older individuals in their seventh decade of life with no gender predilection. Recently, a distinct subtype of cholangiocarcinoma has emerged with 2 proposed names: “cholangioblastic” and “solid tubulocystic.” This variant predominantly occurs in younger women who lack the common risk factors for patients diagnosed with cholangiocarcinomas, such as older age and chronic liver disease or cirrhosis. We describe 3 new patients with a cholangioblastic variant of intrahepatic cholangiocarcinoma. At the time of diagnosis, the patients were aged 19-, 46-, and 28-year-old; 2 females and 1 male (the 46-year-old). None of our patients had a history of chronic liver disease or known predisposing factors for liver tumors. Tumor size ranged from 2.3 to 23 cm in greatest dimension. Histological examination of these tumors demonstrated reproducible morphology characterized by trabecular, nested, and multicystic patterns with micro and macro follicles filled with eosinophilic material. The immunohistochemical profile showed that the tumor cells were positive for keratin 7, inhibin, synaptophysin, and albumin in situ hybridization, while negative for HepPar1, arginase, and INSM1. All tumors lacked conventional intrahepatic cholangiocarcinoma/adenocarcinoma morphology. We also review the literature and emphasize that neuroendocrine tumors should be recognized as a major diagnostic pitfall of this variant.
    Type of Medium: Online Resource
    ISSN: 1066-8969 , 1940-2465
    URL: Article
    DOI: 10.1177/10668969231157775
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2070102-0
    detail.hit.zdb_id: 1336393-1
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  • 4
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    Keratin-Positive Giant Cell-Rich Tumor of Bone Harboring an HMGA2::NCOR2 Fusion: Two Cases, Including a Patient With Metastatic Disease, and Review of the Literature
    SAGE Publications ; 2024
    In:  International Journal of Surgical Pathology Vol. 32, No. 3 ( 2024-05), p. 556-564
    Details
    In: International Journal of Surgical Pathology, SAGE Publications, Vol. 32, No. 3 ( 2024-05), p. 556-564
    Abstract: Giant cell-rich lesions of bone represent a heterogeneous group of entities which classically include giant cell tumor of bone, aneurysmal bone cyst, nonossifying fibroma, and Brown tumor of hyperparathyroidism. A recently described subset of giant cell-rich tumors involving bone and soft tissue has been characterized by recurrent HMGA2::NCOR2 fusions and keratin expression. The overlapping clinical, radiographic, and morphological features of these giant cell-rich lesions provide a unique diagnostic challenge, particularly on biopsy. We present 2 additional cases of keratin-positive giant cell-rich tumor of bone with HMGA2::NCOR2 fusions, including 1 patient who developed metastatic disease.
    Type of Medium: Online Resource
    ISSN: 1066-8969 , 1940-2465
    URL: Article
    DOI: 10.1177/10668969231185076
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 2070102-0
    detail.hit.zdb_id: 1336393-1
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  • 5
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    Acute Appendicitis as the First and the Only Presentation of Systemic Mastocytosis
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  ACG Case Reports Journal Vol. 10, No. 7 ( 2023-7-7), p. e01089-
    Details
    In: ACG Case Reports Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 10, No. 7 ( 2023-7-7), p. e01089-
    Abstract: Systemic mastocytosis is a rare myeloproliferative disorder characterized by abnormal accumulation of mast cells in a variety of organs. When affecting the gastrointestinal tracts, it may manifest with steatorrhea, malabsorption, hepatomegaly, splenomegaly, portal hypertension, and ascites, among others. To our knowledge, only one case of systemic mastocytosis has been reported affecting the appendix. We present another case of a 47-year-old woman who was admitted for right-sided acute abdominal pain and found to have systemic mastocytosis in her appendectomy specimen as the first and only manifestation of her disease.
    Type of Medium: Online Resource
    ISSN: 2326-3253
    URL: Article
    DOI: 10.14309/crj.0000000000001089
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2814825-3
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  • 6
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    The Histopathology of Neoadjuvant-Treated (NAT) Pancreatic Ductal Adenocarcinoma
    Elsevier BV ; 2022
    In:  Surgical Pathology Clinics Vol. 15, No. 3 ( 2022-09), p. 511-528
    Details
    In: Surgical Pathology Clinics, Elsevier BV, Vol. 15, No. 3 ( 2022-09), p. 511-528
    Type of Medium: Online Resource
    ISSN: 1875-9181
    URL: Article
    DOI: 10.1016/j.path.2022.05.010
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
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  • 7
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    Table_3.docx
    Frontiers Media SA ; 2024
    In:  Frontiers in Oncology Vol. 14 ( 2024-5-14)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 14 ( 2024-5-14)
    Abstract: Lymph node metastasis (LNM) is the most significant parameter affecting overall survival in patients with oral cavity squamous cell carcinomas (OCSCC). Elective neck dissection (END) is the standard of care in the early management of OCSCC with a depth of invasion (DOI) greater than 2-4 mm. However, most patients show no LNM in the final pathologic report, indicating overtreatment. Thus, more detailed indicators are needed to predict LNM in patients with OCSCC. In this study, we critically evaluate the existing literature about the risk of different histological parameters in estimating LNM. Methods A systematic review was conducted using PRISMA guidelines. PubMed, Web of Science, Cochrane, and Scopus were searched from inception to December 2023 to collect all relevant studies. Eligibility screening of records was performed, and data extraction from the selected studies was carried out independently. Inclusion in our systematic review necessitated the following prerequisites: Involvement of patients diagnosed with OCSCC, and examination of histological parameters related to lymph node metastasis in these studies. Exclusion criteria included animal studies, non-English articles, non-availability of full text, and unpublished data. Results We included 217 studies in our systematic review, of which 142 were eligible for the meta-analysis. DOI exceeding 4 mm exhibited higher risk for LNM [Risk ratio (RR) 2.18 (1.91-2.48), p & lt;0.00001], as did perineural invasion (PNI) [RR 2.04 (1.77-2.34), p & lt;0.00001], poorly differentiated tumors [RR 1.97 (1.61-2.42), p & lt;0.00001], lymphovascular invasion (LVI) [RR 2.43 (2.12-2.78), p & lt;0.00001], groups and single pattern of invasion [RR 2.47 (2.11-2.89), p & lt;0.00001], high tumor budding [RR 2.65 (1.99-3.52), p & lt;0.00001], tumor size over 4 cm [RR 1.76 (1.43-2.18), p & lt;0.00001], tumor thickness beyond 4 mm [RR 2.72 (1.91-3.87), p & lt;0.00001], involved or close margin [RR 1.73 (1.29-2.33), p = 0.0003] , and T3 and T4 disease [RR 1.98 (1.62-2.41), p & lt;0.00001]. Conclusion Our results confirm the potential usefulness of many histopathological features in predicting LNM and highlight the promising results of others. Many of these parameters are not routinely incorporated into pathologic reports. Future studies must focus on applying these parameters to examine their validity in predicting the need for elective neck treatment.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fonc.2024.1401211
    DOI: 10.3389/fonc.2024.1401211.s001
    DOI: 10.3389/fonc.2024.1401211.s002
    DOI: 10.3389/fonc.2024.1401211.s003
    DOI: 10.3389/fonc.2024.1401211.s004
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2024
    detail.hit.zdb_id: 2649216-7
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  • 8
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    Novel NCOA2/3‐ rearranged low‐grade fibroblastic spindle cell tumors: A report of five cases
    Wiley ; 2024
    In:  Genes, Chromosomes and Cancer Vol. 63, No. 1 ( 2024-01)
    Details
    In: Genes, Chromosomes and Cancer, Wiley, Vol. 63, No. 1 ( 2024-01)
    Abstract: Spindle cell mesenchymal neoplasms are a diverse and often challenging diagnostic group. While morphological impression is sufficient for some diagnoses, increasingly immunohistochemical and even molecular data is required to render an accurate diagnosis, which can lead to the characterization of new entities. We describe five cases of novel mesenchymal neoplasms with rearrangements in the NCOA2 and NCOA3 genes partnered with either CTCF or CRTC1 . Three tumors occurred in the head and neck (palate, auditory canal), while the other two were in visceral organs (lung, urinary bladder). All cases occurred in adults (range 33–86) with a median age of 42 and fairly even sex distribution = (male‐to‐female = 3:2). Morphologically, they had similar features consisting of monotonous, bland spindle to ovoid cells with fascicular and reticular arrangements in a myxohyaline to collagenous stroma. However, immunophenotypically they had essentially a null phenotype, with only two tumors staining partially for CD34 and smooth muscle actin. Targeted RNA sequencing detected in‐frame CTCF::NCOA2 (one case), CRTC1::NCOA2 (two cases), and CTCF::NCOA3 (two cases) fusions. Treatment was surgical resection in all cases. Local recurrence and/or distant metastases were not observed in any case (median follow‐up, 7.5 months; range, 2–19 months). Given their morphologic, immunohistochemical, and molecular similarities, we believe that these cases may represent an emerging family of low‐grade NCOA2/3‐ rearranged fibroblastic spindle cell neoplasms.
    Type of Medium: Online Resource
    ISSN: 1045-2257 , 1098-2264
    URL: Issue
    URL: Article
    DOI: 10.1002/gcc.v63.1
    DOI: 10.1002/gcc.23203
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 1018988-9
    detail.hit.zdb_id: 1492641-6
    SSG: 12
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  • 9
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    Malignant solitary fibrous tumour of the prostate: four cases emphasising significant histological and immunophenotypical overlap with sarcomatoid carcinoma
    Elsevier BV ; 2020
    In:  Pathology Vol. 52, No. 6 ( 2020-10), p. 643-648
    Details
    In: Pathology, Elsevier BV, Vol. 52, No. 6 ( 2020-10), p. 643-648
    Type of Medium: Online Resource
    ISSN: 0031-3025
    URL: Article
    DOI: 10.1016/j.pathol.2020.06.004
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 7085-3
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  • 10
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    Abstract 12917: Incremental Utility of 3D Printing to Guide the Surgical Management of Cardiac Sarcoma
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Circulation Vol. 148, No. Suppl_1 ( 2023-11-07)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 148, No. Suppl_1 ( 2023-11-07)
    Abstract: Background: Intimal sarcoma is an extremely rare and aggressive malignancy that originates in the heart and major vessels. Due to its rarity, ambiguous clinical presentation, and rapid progression, diagnosing and treating this neoplasm presents significant challenges. Case presentation: A 61-year-old female with a history of left atrial sarcoma underwent mass excision in 2019 and 2020, along with several rounds of chemotherapy and immunotherapy. A follow-up cardiac MRI revealed a concerning lesion in the posterior left atrium with evidence of interval size progression on a subsequent CT, suggestive of a recurrence (Panel A). To aid in surgical planning, 3D segmentation of the patient's CT scan was performed, and a 3D model of her heart and lesion were printed (Panel B). This was particularly valuable as it was her third redo surgery, and there were concerns about the surrounding anatomy. Upon reviewing the multimodality imaging and 3D model, the patient was deemed a suitable candidate for a redo surgery. She underwent left atrial sarcoma resection with left atrial floor reconstruction using a bovine pericardial patch and left inferior pulmonary vein reimplantation (Panel C). Histological studies were consistent with recurrent intimal sarcoma (Panel D). The patient is currently in remission. Conclusion: Multimodality imaging was crucial in diagnosing the recurrence of the sarcoma. However, 3D printing of the heart and lesion with detailed segmentation of the left atrium and surrounding structures played a significant role in surgical planning. This highlights the growing use of 3D printing in cardiac surgery planning.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.148.suppl_1.12917
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 1466401-X
    detail.hit.zdb_id: 80099-5
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