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  • 1
    Online Resource
    Online Resource
    Imaging Parameters Predict Recurrence After Transient Ischemic Attack or Minor Stroke Stratified by ABCD 2 Score
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Stroke Vol. 52, No. 6 ( 2021-06), p. 2007-2015
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 52, No. 6 ( 2021-06), p. 2007-2015
    Abstract: Whether imaging parameters would independently predict stroke recurrence in low-risk minor ischemic stroke (MIS) or transient ischemic attack (TIA) according to traditional score system (such as ABCD 2 score, which was termed on the basis of the initials of the five factors: age, blood pressure, clinical features, duration, diabetes) remains unclear. We sought to evaluate the association between imaging parameters and 1-year stroke recurrence in patients with TIA or MIS in different risk stratum stratified by ABCD 2 score. Methods: We included patients with TIA and MIS (National Institutes of Health Stroke Scale score ≤3) with complete baseline vessel and brain imaging data from the Third China National Stroke Registry III. Patients were categorized into different risk groups based on ABCD 2 score (low risk, 0–3; moderate risk, 4–5; and high risk, 6–7). The primary outcome was stroke recurrence within 1 year. Multivariable Cox proportional-hazards regression models were used to assess whether imaging parameters (large artery stenosis, infarction number) were independently associated with stroke recurrence. Results: Of the 7140 patients included, 584 patients experienced stroke recurrence within 1 year. According to the ABCD 2 score, large artery stenosis was associated with higher stroke recurrence in both low-risk (adjusted hazard ratio, 1.746 [95% CI, 1.200–2.540]) and moderate-risk group (adjusted hazard ratio, 1.326 [95% CI, 1.042–1.687] ) but not in the high-risk group ( P 〉 0.05). Patients with multiple acute infarctions or single acute infarction had a higher risk of recurrent stroke than those with no infarction in both low- and moderate-risk groups, but not in the high-risk group. Conclusions: Large artery stenosis and infarction number were independent predictors of 1-year stroke recurrence in low-moderate risk but not in high-risk patients with TIA or MIS stratified by ABCD 2 score. This finding emphasizes the importance of early brain and vascular imaging evaluation for risk stratification in patients with TIA or MIS.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/STROKEAHA.120.032424
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 1467823-8
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  • 2
    Online Resource
    Online Resource
    Nucleation and Grain Refinement of 7A04 Aluminum Alloy Under a Low-Power Electromagnetic Pulse
    Springer Science and Business Media LLC ; 2018
    In:  Journal of Materials Engineering and Performance Vol. 27, No. 2 ( 2018-2), p. 857-863
    Details
    In: Journal of Materials Engineering and Performance, Springer Science and Business Media LLC, Vol. 27, No. 2 ( 2018-2), p. 857-863
    Type of Medium: Online Resource
    ISSN: 1059-9495 , 1544-1024
    URL: Article
    DOI: 10.1007/s11665-018-3128-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 2048384-3
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  • 3
    Online Resource
    Online Resource
    MicroRNA-375 is a therapeutic target for castration-resistant prostate cancer through the PTPN4/STAT3 axis
    Springer Science and Business Media LLC ; 2022
    In:  Experimental & Molecular Medicine Vol. 54, No. 8 ( 2022-08-30), p. 1290-1305
    Details
    In: Experimental & Molecular Medicine, Springer Science and Business Media LLC, Vol. 54, No. 8 ( 2022-08-30), p. 1290-1305
    Abstract: The functional role of microRNA-375 (miR-375) in the development of prostate cancer (PCa) remains controversial. Previously, we found that plasma exosomal miR-375 is significantly elevated in castration-resistant PCa (CRPC) patients compared with castration-sensitive PCa patients. Here, we aimed to determine how miR-375 modulates CRPC progression and thereafter to evaluate the therapeutic potential of human umbilical cord mesenchymal stem cell (hucMSC)-derived exosomes loaded with miR-375 antisense oligonucleotides (e-375i). We used miRNA in situ hybridization technique to evaluate miR-375 expression in PCa tissues, gain- and loss-of-function experiments to determine miR-375 function, and bioinformatic methods, dual-luciferase reporter assay, qPCR, IHC and western blotting to determine and validate the target as well as the effects of miR-375 at the molecular level. Then, e-375i complexes were assessed for their antagonizing effects against miR-375. We found that the expression of miR-375 was elevated in PCa tissues and cancer exosomes, correlating with the Gleason score. Forced expression of miR-375 enhanced the expression of EMT markers and AR but suppressed apoptosis markers, leading to enhanced proliferation, migration, invasion, and enzalutamide resistance and decreased apoptosis of PCa cells. These effects could be reversed by miR-375 silencing. Mechanistically, miR-375 directly interfered with the expression of phosphatase nonreceptor type 4 (PTPN4), which in turn stabilized phosphorylated STAT3. Application of e-375i could inhibit miR-375, upregulate PTPN4 and downregulate p-STAT3, eventually repressing the growth of PCa. Collectively, we identified a novel miR-375 target, PTPN4, that functions upstream of STAT3, and targeting miR-375 may be an alternative therapeutic for PCa, especially for CRPC with high AR levels.
    Type of Medium: Online Resource
    ISSN: 2092-6413
    URL: Article
    DOI: 10.1038/s12276-022-00837-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2084833-X
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  • 4
    Online Resource
    Online Resource
    Crystal orientation and crystal structure of paramagnetic α-Al under a pulsed electromagnetic field
    Springer Science and Business Media LLC ; 2020
    In:  Scientific Reports Vol. 10, No. 1 ( 2020-06-30)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2020-06-30)
    Abstract: The intermittent electromagnetic fields with a large $$\partial \mathrm{B}/\partial \mathrm{t}$$ ∂ B / ∂ t can enhance the properties of ferromagnetic materials and significantly affect paramagnetic materials. In this study, the effect of a pulsed electromagnetic field on the crystal orientation of the primary phase and microstructure evolution of an Al–Zn–Mg–Cu alloy was investigated. A mathematical model was developed to describe crystal rotation under a pulsed electromagnetic field. The model predictions show that the magnetic energy difference generated by the magnetic anisotropy of the primary crystal produces primary phases with sizes of 225–100 μm to rotate into a 〈 111 〉 preferred orientation. The lattice constant, the interplanar spacing, and the microstrain increase with the duty cycle of the pulsed magnetic field, especially for the (111) and (200) crystal planes. This study provides preliminary theoretical support for using pulsed electromagnetic fields to control the orientation and microscopic properties of materials.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-020-67352-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2615211-3
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  • 5
    Online Resource
    Online Resource
    Container cascade fault detection based on spatial–temporal correlation in cloud environment
    Springer Science and Business Media LLC ; 2023
    In:  Journal of Cloud Computing Vol. 12, No. 1 ( 2023-04-17)
    Details
    In: Journal of Cloud Computing, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2023-04-17)
    Abstract: Containers are light, numerous, and interdependent, which are prone to cascading fault, increasing the probability of fault and the difficulty of detection. Existing detection methods are usually based on a cascade fault model with traditional association analysis. The tradition model lacks consideration of the fault cascade history dimension and container space correlation dimension which results in a lower detection effect. And the imbalance of fault data in the cloud environment to the detection method to bring interference. Instead, this paper proposes a cascade fault detection method based on spatial–temporal correlation in cloud environment. First, the container cascade fault relationship model is constructed by extracting the spatial–temporal correlation from historical container faults. Second, based on dynamic feedback data sampling combined with ensemble learning, a container fault model learning method is designed to solve the imbalance of fault data. Then, a real-time container cascade fault detection mechanism for container cascade failure is proposed. The experimental results show that compared with the existing fault detection methods, the proposed method can effectively improve the detection accuracy, recall rate, and F 1 value.
    Type of Medium: Online Resource
    ISSN: 2192-113X
    URL: Article
    DOI: 10.1186/s13677-023-00438-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2682472-3
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  • 6
    Online Resource
    Online Resource
    Table_1.DOCX
    Frontiers Media SA ; 2021
    In:  Frontiers in Cell and Developmental Biology Vol. 9 ( 2021-3-16)
    Details
    In: Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 9 ( 2021-3-16)
    Abstract: Ectodermal neural cortex 1 (ENC1) is an actin-binding protein and has been known to be upregulated in several cancers, but the molecular mechanisms through which it contributes to the pathology of CRC have largely been elusive. We utilized data mining and validated the aberrant expression of ENC1, following which phenotypic traits of malignancy were assessed in vitro . Ruxolitinib was used as a surrogate to compare the effects of ENC1 expression and silencing on the JAK-STAT-AKT pathway. In vivo models were employed to confirm the in vitro observations. Computation analysis, strengthened by in situ and in vitro data, confirmed the overexpression of ENC1 in CRC and predicted a poor prognosis, while enhanced cell proliferation, invasion, migration, EMT, and stemness were associated with ENC1 overexpression. Silencing of ENC1 downregulated the phenotypes. Additionally, silencing of ENC1 significantly reduced the activation of JAK2 and consequent activation of STAT5 and AKT comparable to ruxolitinib inhibition of JAK2. Silencing of ENC1 resulted in lesser tumor volumes and fewer numbers of tumors, in vivo . These data suggest that ENC1 induces CRC through the JAK2-STAT5-AKT axis. ENC1 is a suitable diagnostic marker for CRC detection, and ENC1 targeting therapies may suppress CRC progression.
    Type of Medium: Online Resource
    ISSN: 2296-634X
    URL: Article
    URL: Article
    DOI: 10.3389/fcell.2021.616887
    DOI: 10.3389/fcell.2021.616887.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2737824-X
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  • 7
    Online Resource
    Online Resource
    Charging a Smartphone Over the Air: The Resonant Beam Charging Method
    Institute of Electrical and Electronics Engineers (IEEE) ; 2022
    In:  IEEE Internet of Things Journal Vol. 9, No. 15 ( 2022-8-1), p. 13876-13885
    Details
    In: IEEE Internet of Things Journal, Institute of Electrical and Electronics Engineers (IEEE), Vol. 9, No. 15 ( 2022-8-1), p. 13876-13885
    Type of Medium: Online Resource
    ISSN: 2327-4662 , 2372-2541
    URL: Article
    DOI: 10.1109/JIOT.2022.3142031
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2022
    detail.hit.zdb_id: 2751199-6
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  • 8
    Online Resource
    Online Resource
    Research on Microstructure and Properties of 304 Stainless Steel Made by MIG Filler Additive Manufacturing
    IOP Publishing ; 2019
    In:  IOP Conference Series: Earth and Environmental Science Vol. 237 ( 2019-03-19), p. 032096-
    Details
    In: IOP Conference Series: Earth and Environmental Science, IOP Publishing, Vol. 237 ( 2019-03-19), p. 032096-
    Type of Medium: Online Resource
    ISSN: 1755-1315
    URL: Article
    DOI: 10.1088/1755-1315/237/3/032096
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2019
    detail.hit.zdb_id: 2434538-6
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  • 9
    Online Resource
    Online Resource
    Effects of rolling rate on microstructure and mechanical properties of Mg sheets
    Walter de Gruyter GmbH ; 2014
    In:  International Journal of Materials Research Vol. 105, No. 5 ( 2014-05-13), p. 502-506
    Details
    In: International Journal of Materials Research, Walter de Gruyter GmbH, Vol. 105, No. 5 ( 2014-05-13), p. 502-506
    Abstract: This study investigates the effects of rolling rate on the microstructure and mechanical properties of magnesium alloy sheets. AZ31 plates were rolled at speeds of 5, 10, 20 and 30 r · min −1 at room temperature. Optical microscopy, micro-hardness testing, and X-ray diffraction were carried out to characterize the material microstructure. Results show that the number of twin grains increases as the rolling rate increases. Simultaneously, the micro-hardness of the samples decreases, and the (0 001) basal texture is weakened. These results suggest the use of high rolling speed to practically reduce the formation of unfavorable basal texture in manufacturing magnesium alloy sheets.
    Type of Medium: Online Resource
    ISSN: 2195-8556 , 1862-5282
    URL: Article
    DOI: 10.3139/146.111060
    RVK:
    ZG 1100
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2014
    detail.hit.zdb_id: 2232675-3
    detail.hit.zdb_id: 2128058-7
    detail.hit.zdb_id: 203021-4
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  • 10
    Online Resource
    Online Resource
    LC-MS-Based Lipidomic Analysis of Serum Samples from Patients with Type 2 Diabetes Mellitus (T2DM)
    Hindawi Limited ; 2022
    In:  Disease Markers Vol. 2022 ( 2022-2-12), p. 1-11
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2022 ( 2022-2-12), p. 1-11
    Abstract: Background. With the development of social economy, type 2 diabetes mellitus (T2DM) is becoming a severe health problem globally. Methods. To systematically understand the lipid metabolism in T2DM, we applied untargeted lipidomics to the serum of T2DM patients and control group using ultrahigh-performance liquid chromatography (UHPLC) coupled with high-resolution mass spectrometry (MS). Results. Over two thousand molecular features were detected by our approach, of which 222 lipid species in positive ion mode and 145 species in negative were reliably identified based on precise molecular weights and MS/MS patterns. Multivariate analysis was adopted to differentiate T2DM patients and the control group using principal component analysis (PCA) and orthogonal partial least squares discrimination analysis (OPLS-DA). The dysregulated lipid species were found and their significance in pathophysiology was discussed. Correlation analysis of selected lipids and important clinical variables was performed and addressed. Conclusions. This study unveils several new lipids and pathways considerably involved in T2DM and provides novel insights into understanding the pathogenesis underlying T2DM.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2022/5559470
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2033253-1
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