In:
FEBS Letters, Wiley, Vol. 408, No. 2 ( 1997-05-19), p. 211-216
Abstract:
We have studied the biological properties of a new human CC chemokine, CKβ8, consisting of 99 amino acids including six cysteines. CKβ8 mRNA transcripts were induced in monocytes by IL‐1β and, to a lesser extent, by IFNγ, and were detected in RNA extracted from normal human liver and gastrointestinal tract. CKβ8 is chemotactic for monocytes, but is inactive on IL‐2 conditioned T lymphocytes, eosinophils and neutrophils. Desensitization experiments indicate that CKβ8 and MIP‐1β completely share receptors on monocytes and that the CKβ8 receptor, which appears to differ from the known ones, is also recognized by MCP‐1, MCP‐2, MCP‐3, MCP‐4, MIP‐1α and RANTES.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(97)00408-0
Language:
English
Publisher:
Wiley
Publication Date:
1997
detail.hit.zdb_id:
1460391-3
SSG:
12
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