In:
Frontiers in Microbiology, Frontiers Media SA, Vol. 15 ( 2024-4-29)
Abstract:
The effects of fructo-oligosaccharides (FOS) on atopic dermatitis (AD) have not been determined. Methods In a randomized, double-blind, placebo-controlled trial, children with AD aged 24 months to 17 years received either advanced FOS containing 4.25 g of 1-kestose or a placebo (maltose) for 12 weeks. Results The SCORAD and itching scores were reduced in patients treated with both FOS (all p & lt; 0.01) and maltose ( p & lt; 0.05 and p & lt; 0.01). Sleep disturbance was improved only in the FOS group ( p & lt; 0.01). The FOS group revealed a decreased proportion of linoleic acid (18:2) esterified omega-hydroxy-ceramides (EOS-CERs) with amide-linked shorter chain fatty acids (C28 and C30, all p & lt; 0.05), along with an increased proportion of EOS-CERs with longer chain fatty acids (C32, p & lt; 0.01). Discussion FOS may be beneficial in alleviating itching and sleep disturbance, as well as improving skin barrier function in children with AD.
Type of Medium:
Online Resource
ISSN:
1664-302X
DOI:
10.3389/fmicb.2024.1383779
DOI:
10.3389/fmicb.2024.1383779.s001
DOI:
10.3389/fmicb.2024.1383779.s002
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2024
detail.hit.zdb_id:
2587354-4
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