In:
Journal of Osteoporosis, Hindawi Limited, Vol. 2016 ( 2016), p. 1-10
Abstract:
Osteoporosis and increased arterial stiffness independently have been found to be associated with higher cardiovascular events rates in the general population (GP). We examined 558 patients from GP by dual-energy X-ray absorptiometry (DXA) and pulse wave velocity (PWV) measurements at baseline, with 36-month follow-up period. DXA assessed bone mineral density of femoral neck (BMD FN) and lumbar spine (BMD LS). Carotid-femoral PWV was assessed by pulsed-Doppler. The aim of our study is to find correlation between bone strength and arterial stiffness and their impact on cardiovascular mortality in GP. The mean ± SD of BMD FN, BMD LS, and PWV was 0.852 ± 0.1432 g/cm 2 , 0.934 ± 0.1546 g/cm 2 , and 9.209 ± 1.9815 m/s. In multiple regression analysis we found BMD FN ( β st = - 6.0094 , p 〈 0.0001 ), hypertension ( β st = 1.7340, p 〈 0.0091 ), and diabetes ( β s t = 0.4595 , p 〈 0.0046 ). With Cox-regression analysis, after 17 cardiovascular events, the significant covariates retained by the backward model were BMD FN ( b = - 2.4129 , p = 0.015 ) and PWV ( b = 0.2606 , p = 0.0318 ). The cut-off values were PWV = 9.4 m/s, BMD FN = 0.783 g/cm 2 , and BMD LS = 0.992 g/cm 2 . The results for BMD FN and PWV hazard ratio risk were 1.116 and 1.297, respectively. BMD FN as a measure of bone strength and PWV as a measure of arterial stiffness are strong independent predictors of cardiovascular mortality in GP.
Type of Medium:
Online Resource
ISSN:
2090-8059
,
2042-0064
DOI:
10.1155/2016/7030272
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2016
detail.hit.zdb_id:
2549002-3
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