In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 4 ( 2023-4-28), p. e0285042-
Abstract:
In 2020, the Department of Energy established the National Virtual Biotechnology Laboratory (NVBL) to address key challenges associated with COVID-19. As part of that effort, Pacific Northwest National Laboratory (PNNL) established a capability to collect and analyze specimens from employees who self-reported symptoms consistent with the disease. During the spring and fall of 2021, 688 specimens were screened for SARS-CoV-2, with 64 (9.3%) testing positive using reverse-transcriptase quantitative PCR (RT-qPCR). Of these, 36 samples were released for research. All 36 positive samples released for research were sequenced and genotyped. Here, the relationship between patient age and viral load as measured by Ct values was measured and determined to be only weakly significant. Consensus sequences for each sample were placed into a global phylogeny and transmission dynamics were investigated, revealing that the closest relative for many samples was from outside of Washington state, indicating mixing of viral pools within geographic regions.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0285042
DOI:
10.1371/journal.pone.0285042.g001
DOI:
10.1371/journal.pone.0285042.g002
DOI:
10.1371/journal.pone.0285042.g003
DOI:
10.1371/journal.pone.0285042.g004
DOI:
10.1371/journal.pone.0285042.g005
DOI:
10.1371/journal.pone.0285042.g006
DOI:
10.1371/journal.pone.0285042.g007
DOI:
10.1371/journal.pone.0285042.t001
DOI:
10.1371/journal.pone.0285042.t002
DOI:
10.1371/journal.pone.0285042.s001
DOI:
10.1371/journal.pone.0285042.r001
DOI:
10.1371/journal.pone.0285042.r002
DOI:
10.1371/journal.pone.0285042.r003
DOI:
10.1371/journal.pone.0285042.r004
DOI:
10.1371/journal.pone.0285042.r005
DOI:
10.1371/journal.pone.0285042.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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