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  • 1
    In: Case Reports in Women's Health, Elsevier BV, Vol. 39 ( 2023-09), p. e00529-
    Type of Medium: Online Resource
    ISSN: 2214-9112
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2800286-6
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  • 2
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Obstetrical & Gynecological Survey Vol. 78, No. 1 ( 2023-1), p. 50-68
    In: Obstetrical & Gynecological Survey, Ovid Technologies (Wolters Kluwer Health), Vol. 78, No. 1 ( 2023-1), p. 50-68
    Abstract: Obesity is one of the most common clinical entities complicating pregnancies and is associated with short- and long-term consequences for both the mother and the offspring. Objective The aim of this study were to review and compare the most recently published influential guidelines on the management of maternal obesity in the preconceptional, antenatal, intrapartum, and postpartum period. Evidence Acquisition A descriptive review of guidelines from the American College of Obstetricians and Gynecologists, the International Federation of Gynecology and Obstetrics, the Society of Obstetricians and Gynecologists of Canada, the Royal College of Obstetricians and Gynecologists, and the Royal Australian and New Zealand College of Obstetricians and Gynecologists on obesity in pregnancy was carried out. Results There is an overall agreement among the reviewed guidelines regarding the importance of prepregnancy weight loss with behavioral modification, optimization of gestational weight gain, and screening for comorbidities in improving pregnancy outcomes of obese women. Women with previous bariatric surgery should be screened for nutritional deficiencies and have a closer antenatal surveillance, according to all guidelines. In addition, folic acid supplementation is recommended for 1 to 3 months before conception and during the first trimester, but several discrepancies were identified with regard to other vitamins, iodine, calcium, and iron supplementation. All medical societies recommend early screening for gestational diabetes mellitus and early anesthetic assessment in obese women and suggest the use of aspirin for the prevention of preeclampsia when additional risk factors are present, although the optimal dosage is controversial. The International Federation of Gynecology and Obstetrics, Society of Obstetricians and Gynecologists of Canada, Royal College of Obstetricians and Gynecologists, and Royal Australian and New Zealand College of Obstetricians and Gynecologists point out that specific equipment and adequate resources must be readily available in all health care facilities managing obese pregnant women. Moreover, thromboprophylaxis and prophylactic antibiotics are indicated in case of cesarean delivery, and intrapartum fetal monitoring is justified during active labor in obese patients. However, there are no consistent protocols regarding the fetal surveillance, the monitoring of multiple gestations, the timing and mode of delivery, and the postpartum follow-up, although weight loss and breastfeeding are unanimously supported. Conclusions Obesity in pregnancy is a significant contributor to maternal and perinatal morbidity with a constantly rising global prevalence among reproductive-aged women. Thus, the development of uniform international protocols for the effective management of obese women is of paramount importance to safely guide clinical practice and subsequently improve pregnancy outcomes. Target Audience Obstetricians and gynecologists, family physicians. Learning Objectives After participating in this activity, the learner should be able to assess maternal obesity and describe its associated pregnancy complications; explain the preconceptional, antenatal, and intrapartum management of obese pregnant women; and propose strategies for the postpartum management of obese women.
    Type of Medium: Online Resource
    ISSN: 1533-9866 , 0029-7828
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2043471-6
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  • 3
    In: Medicina, MDPI AG, Vol. 59, No. 6 ( 2023-06-03), p. 1080-
    Abstract: Objectives: To assess the incidence of prenatally diagnosed isolated single umbilical artery (iSUA) and its impact on major pregnancy outcomes, as well as to investigate potential risk factors. Materials and methods: A prospective study of singleton pregnancies, undergoing routine anomaly scans at 20+0–24+0 weeks of gestation, was carried out from 2018 to 2022. The effect of sonographically detected iSUA on small-for-gestational-age neonates (SGA) and preterm delivery (PTD) was evaluated using parameterized Student’s t-test, nonparametric Mann–Whitney U test and the chi-square test. Multivariable logistic regression models were implemented to assess the independent association between iSUA and the main outcomes, as well as with potential risk factors, while adjusting for specific confounders. Results: The study population included 6528 singleton pregnancies and the incidence of prenatally diagnosed iSUA was 1.3%. Prenatally diagnosed iSUA had a statistically significant association with both SGA neonates (aOR: 1.909; 95% CI: 1.152–3.163) and PTD (aOR: 1.903; 95% CI: 1.035–3.498), while no association was identified between this sonographic finding and preeclampsia. With regard to risk factors, conception via assisted reproductive technology (ART) was associated with increased risk of iSUA (aOR: 2.234; 95% CI: 1.104–4.523), while no other independent predictor for the development of this anatomical variation was identified. Conclusions: Prenatally diagnosed iSUA seems to be associated with a higher incidence of SGA and PTD and is more common in pregnancies following ART, which constitutes a novel finding.
    Type of Medium: Online Resource
    ISSN: 1648-9144
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2088820-X
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  • 4
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Obstetrical & Gynecological Survey Vol. 75, No. 7 ( 2020-7), p. 419-430
    In: Obstetrical & Gynecological Survey, Ovid Technologies (Wolters Kluwer Health), Vol. 75, No. 7 ( 2020-7), p. 419-430
    Abstract: Twin pregnancies are associated with a higher risk of perinatal mortality and morbidity compared with singleton and require more intensive prenatal care. Objective The aim of this study was to review and compare the recommendations from published guidelines on twin pregnancies. Evidence Acquisition A descriptive review of guidelines from the Royal College of Obstetricians and Gynaecologists, the International Society of Ultrasound in Obstetrics and Gynecology, the Royal Australian and New Zealand College of Obstetricians and Gynaecologists, the National Institute for Health and Care Excellence, the Institute of Obstetricians and Gynaecologists of the Royal College of Physicians of Ireland, the International Federation of Gynecology and Obstetrics, the Society of Obstetricians and Gynaecologists of Canada, and the American College of Obstetricians and Gynecologists on the management of twin pregnancies was conducted. Results All the guidelines highlight the importance of an accurate assessment of chorionicity, amnionicity, and gestational age in the first trimester. They also recommend the performance of nuchal translucency and a detailed anomaly scan. The ultrasound surveillance protocol is similar in all guidelines, that is, every 2 weeks for monochorionic and every 4 weeks for dichorionic twins. On the other hand, there are differences regarding the timing and mode of delivery, especially in monochorionic diamniotic twins, in the definition and management of fetal growth discordance, the use of cervical length to screen for preterm birth, and the timing of corticosteroids' administration. Conclusions The differences in the reviewed guidelines on the management of twin pregnancies highlight the need for an adoption of an international consensus, in order to improve perinatal outcomes of twin pregnancies. Target Audience Obstetricians and gynecologists, family physicians Learning Objectives After participating in this activity, the learner should be better able to identify all aspects of the antenatal surveillance of twin pregnancies and the importance of first trimester determination of chorionicity; explain the birth issues of twin pregnancies, including recommendations on mode and timing of delivery; and describe the possible complications in pregnancy, their association with chorionicity, and appropriate management.
    Type of Medium: Online Resource
    ISSN: 1533-9866 , 0029-7828
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2043471-6
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  • 5
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Obstetrical & Gynecological Survey Vol. 74, No. 3 ( 2019-3), p. 161-169
    In: Obstetrical & Gynecological Survey, Ovid Technologies (Wolters Kluwer Health), Vol. 74, No. 3 ( 2019-3), p. 161-169
    Abstract: Nausea and vomiting of pregnancy (NVP) affects a high proportion of the pregnant population. Objective The aim of this study was to compare and synthesize recommendations from national guidelines regarding the management of NVP. Evidence Acquisition A descriptive review of 3 recently published national guidelines on NVP was conducted: Royal College of Obstetricians and Gynaecologists on “The Management of Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum,” American College of Obstetricians and Gynecologists on “Nausea and Vomiting of Pregnancy,” and Society of Obstetricians and Gynaecologists of Canada on “The Management of Nausea and Vomiting of Pregnancy.” These guidelines were summarized and compared in terms of the recommended management of pregnant women. The quality of evidence was also reviewed based on the method of reporting. Results Several differences were identified on the different guidelines regarding the management of NVP. Frequent small meals and avoidance of iron supplements are recommended for prevention. The consumption of ginger, acustimulations, antihistamines, phenothiazines, dopamine, and serotonin 5-hydroxytryptamine type 3 receptor antagonists is routinely recommended for use in the community as treatment. Conclusions Evidence-based medicine may lead to the adoption of an international guideline for the management of NVP, which may lead to a more effective management of that entity. Target Audience Obstetricians and gynecologists, family physicians. Learning Objectives After participating in this activity, the learner should be better able to synthesize management recommendations in cases of NVP; assess the preventive and nonpharmacologic regimens in cases of NVP; and propose the necessary pharmacologic treatment in cases of NVP.
    Type of Medium: Online Resource
    ISSN: 1533-9866 , 0029-7828
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2043471-6
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  • 6
    In: Current Vascular Pharmacology, Bentham Science Publishers Ltd., Vol. 20, No. 1 ( 2022-01), p. 52-61
    Abstract: Arterial stiffness (AS) describes the rigidity of the arterial walls. Epidemiological studies have shown that increased AS is an independent predictive marker of cardiovascular (CV) morbidity and mortality in both pregnant and non-pregnant women. Preeclampsia (PE), a form of pregnancy-induced hypertension, affects approximately 5% of pregnancies worldwide. Preeclamptic women have a higher risk of CV disease (CVD), mainly because PE damages the heart’s ability to relax between contractions. Different pharmacologica l approaches for the prevention of PE have been tested in clinical trials (e.g. aspirin, enoxaparin, metformin, pravastatin, and sildenafil citrate). In current clinical practice, only low-dose aspirin is used for PE pharmacoprevention. However, low-dose aspirin does not prevent term PE, which is the most common form of PE. Compromised vascular integrity precedes the onset of PE and therefore, AS assessment may constitute a promising predictive marker of PE. Several non-invasive techniques have been developed to assess AS. Compared with normotensive pregnancies, both carotid-femoral pulse wave velocity (cfPWV) and augmentation index (AIx) are increased in PE. In view of simplicity, reliability, and reproducibility, there is an interest in oscillometric AS measurements in pregnancies complicated by PE.
    Type of Medium: Online Resource
    ISSN: 1570-1611
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2022
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  • 7
    In: Children, MDPI AG, Vol. 10, No. 7 ( 2023-07-14), p. 1220-
    Abstract: Hypoglycemia represents one of the most frequent metabolic disturbances of the neonate, associated with increased morbidity and mortality, especially if left untreated or diagnosed after the establishment of brain damage. The aim of this study was to review and compare the recommendations from the most recently published influential guidelines on the diagnosis, screening, prevention and management of this common neonatal complication. Therefore, a descriptive review of the guidelines from the American Academy of Pediatrics (AAP), the British Association of Perinatal Medicine (BAPM), the European Foundation for the Care of the Newborn Infants (EFCNI), the Queensland Clinical Guidelines-Australia (AUS), the Canadian Pediatric Society (CPS) and the Pediatric Endocrine Society (PES) on neonatal hypoglycemia was carried out. There is a consensus among the reviewed guidelines on the risk factors, the clinical signs and symptoms of NH, and the main preventive strategies. Additionally, the importance of early recognition of at-risk infants, timely identification of NH and prompt initiation of treatment in optimizing the outcomes of hypoglycemic neonates are universally highlighted. All medical societies, except PES, recommend screening for NH in asymptomatic high-risk and symptomatic newborn infants, but they do not provide consistent screening approaches. Moreover, the reviewed guidelines point out that the diagnosis of NH should be confirmed by laboratory methods of BGL measurement, although treatment should not be delayed until the results become available. The definition of NH lacks uniformity and it is generally agreed that a single BG value cannot accurately define this clinical entity. Therefore, all medical societies support the use of operational thresholds for the management of NH, although discrepancies exist regarding the recommended cut-off values, the optimal treatment and surveillance strategies of both symptomatic and asymptomatic hypoglycemic neonates as well as the treatment targets. Over the past several decades, ΝH has remained an issue of keen debate as it is a preventable cause of brain injury and neurodevelopmental impairment; however, there is no clear definition or consistent treatment policies. Thus, the establishment of specific diagnostic criteria and uniform protocols for the management of this common biochemical disorder is of paramount importance as it will hopefully allow for the early identification of infants at risk, the establishment of efficient preventive measures, the optimal treatment in the first hours of a neonate’s life and, subsequently, the improvement of neonatal outcomes.
    Type of Medium: Online Resource
    ISSN: 2227-9067
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2732685-8
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  • 8
    Online Resource
    Online Resource
    Informa UK Limited ; 2019
    In:  Journal of Obstetrics and Gynaecology Vol. 39, No. 7 ( 2019-10-03), p. 1030-1031
    In: Journal of Obstetrics and Gynaecology, Informa UK Limited, Vol. 39, No. 7 ( 2019-10-03), p. 1030-1031
    Type of Medium: Online Resource
    ISSN: 0144-3615 , 1364-6893
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2007571-6
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  • 9
    In: The Journal of Maternal-Fetal & Neonatal Medicine, Informa UK Limited, Vol. 35, No. 13 ( 2022-07-03), p. 2493-2498
    Type of Medium: Online Resource
    ISSN: 1476-7058 , 1476-4954
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2080626-7
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  • 10
    Online Resource
    Online Resource
    Walter de Gruyter GmbH ; 2019
    In:  Journal of Perinatal Medicine Vol. 47, No. 8 ( 2019-10-25), p. 817-821
    In: Journal of Perinatal Medicine, Walter de Gruyter GmbH, Vol. 47, No. 8 ( 2019-10-25), p. 817-821
    Abstract: To investigate the correlation between transperineal (TP) and transvaginal (TV) ultrasonography in the measurement of cervical length (CL) in the third trimester of pregnancy. Methods In this prospective study, CL measurements were conducted in women between 31 and 34 weeks of gestation by both the TP and TV approaches. A comparison of the measurements was made between the two techniques. The Pearson correlation coefficient, the paired samples t -test and Bland-Altman plot were used. Results In total, 240 women participated in the study. The CL was successfully measured transvaginally in all cases and transperineally in 229 (95.4%) of the cases. The mean TV CL was 32.8 ± 8.2 mm and the mean TP CL was 32.5 ± 8.1 mm. In the 229 cases with paired measurements, the Pearson correlation coefficient was 0.964. No significant differences in mean CL were identified between the two methods ( t  = 1.805; P = 0.072). In the Bland-Altman plot, the difference between the paired means was 0.26 mm and the 95% tolerance interval for any given paired observation (TV CL–TP CL) was −4.05 to 4.57 mm. Conclusion The findings of this study suggest that at 31–34 weeks of gestation the cervix can be visualized adequately by both the TV and TP sonography in about 95% of cases. The TP CL measurements demonstrate a close correlation with the TV measurements. TP ultrasound is a feasible alternative, especially in cases where the use of the vaginal transducer should be minimized or is not acceptable by women.
    Type of Medium: Online Resource
    ISSN: 1619-3997 , 0300-5577
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2019
    detail.hit.zdb_id: 1467968-1
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