In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 8 ( 2022-8-22), p. e0272920-
Abstract:
This study aimed to assess the global prevalence of occult hepatitis B in blood donors. We searched PubMed, Web of Science, Global Index Medicus, and Excerpta Medica Database. Study selection and data extraction were performed by at least two independent investigators. Heterogeneity (I 2 ) was assessed using the χ 2 test on the Cochran Q statistic and H parameters. Sources of heterogeneity were explored by subgroup analyses. This study is registered with PROSPERO, number CRD42021252787. We included 82 studies in this meta-analysis. The overall prevalence of OBI was 6.2% (95% CI: 5.4–7.1) in HBsAg negative and anti-HBc positive blood donors. Only sporadic cases of OBI were reported in HBsAg negative and anti-HBc negative blood donors. The overall prevalence of OBI was 0.2% (95% CI: 0.1–0.4) in HBsAg negative blood donors. The prevalence of OBI was generally higher in countries with low-income economic status. The results of this study show that despite routine screening of blood donors for hepatitis B, the transmission of HBV by blood remains possible via OBI and/or a seronegative window period; hence there is a need for active surveillance and foremost easier access to molecular tests for the screening of blood donors before transfusion.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0272920
DOI:
10.1371/journal.pone.0272920.g001
DOI:
10.1371/journal.pone.0272920.g002
DOI:
10.1371/journal.pone.0272920.g003
DOI:
10.1371/journal.pone.0272920.g004
DOI:
10.1371/journal.pone.0272920.g005
DOI:
10.1371/journal.pone.0272920.t001
DOI:
10.1371/journal.pone.0272920.s001
DOI:
10.1371/journal.pone.0272920.s002
DOI:
10.1371/journal.pone.0272920.s003
DOI:
10.1371/journal.pone.0272920.s004
DOI:
10.1371/journal.pone.0272920.s005
DOI:
10.1371/journal.pone.0272920.s006
DOI:
10.1371/journal.pone.0272920.s007
DOI:
10.1371/journal.pone.0272920.s008
DOI:
10.1371/journal.pone.0272920.s009
DOI:
10.1371/journal.pone.0272920.s010
DOI:
10.1371/journal.pone.0272920.s011
DOI:
10.1371/journal.pone.0272920.s012
DOI:
10.1371/journal.pone.0272920.s013
DOI:
10.1371/journal.pone.0272920.s014
DOI:
10.1371/journal.pone.0272920.s015
DOI:
10.1371/journal.pone.0272920.r001
DOI:
10.1371/journal.pone.0272920.r002
DOI:
10.1371/journal.pone.0272920.r003
DOI:
10.1371/journal.pone.0272920.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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