In:
The Journal of Dermatology, Wiley, Vol. 46, No. 6 ( 2019-06), p. 540-543
Abstract:
Toxic epidermal necrolysis ( TEN ) is a rare condition, causing life‐threatening adverse cutaneous reactions. TEN occurrence after bone marrow transplantation ( BMT ) is a well‐known phenomenon; however, to date, only a few cases have been reported in the published work. Here, we describe the case of a 53‐year‐old woman who experienced TEN after undergoing allogenic BMT for malignant lymphoma. Skin erosion spread across a maximum of 70% of the body surface area and severe mucosal lesions developed. Steroid pulse therapy, plasma apheresis and immunoglobulin therapy were administrated, which resulted in the complete resolution of TEN . However, she developed hemophagocytic lymphohistiocytosis and died 38 days after BMT , owing to rupture of the lower digestive tract complicated by multi‐organ failure. In our case, engraftment failure occurred, and the peripheral white blood cell count was less than 100/μL during the TEN course, suggesting that the presence of only a few immune cells could cause TEN . Our findings showed that high mortality rates and widespread skin erosion could be regarded as the most important characteristics of TEN occurring after BMT .
Type of Medium:
Online Resource
ISSN:
0385-2407
,
1346-8138
DOI:
10.1111/jde.2019.46.issue-6
DOI:
10.1111/1346-8138.14913
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2222121-9
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