In:
Sleep, Oxford University Press (OUP), ( 2019-09-26)
Abstract:
Little is known about comorbidities in children who have elevated periodic limb movement index (PLMI) during overnight polysomnogram (PSG). The aim of this study is to identify comorbidities in children with elevated PLMI (PLMI 〉 5) versus children with PLMI 〈 5 presenting to a pediatric sleep center. Methods This study was a retrospective review of all clinically indicated PSGs obtained consecutively from 3/2017-3/2019 at Seattle Children’s Sleep Disorders Center. Data collected included demographics, clinical presentation, medications, medical history, family history specifically for restless legs syndrome (RLS), ferritin levels, and PSG metrics. Characteristics between those with (cases) elevated PLMI (AASM criteria) and without (controls) were summarized. Results We identified 148 subjects with elevated PLMI (67% male, mean age 7.95 years, range 1–20), yielding a PLMI 〉 5 prevalence of 5%. There were 188 controls included (58% male, mean age 8.0 years, range 1–19). Neither sex (chi-square = 2.8, NS) nor age (Mann–Whitney U = 1339.5, NS) differed between groups. Case subjects had a higher prevalence of RLS, snoring, insomnia, mood disorders, behavioral problems, morning headaches, chronic kidney disease, epilepsy, and chronic heart disease. Similarly, the use of antidepressants, antipsychotics, antiseizure medication, and other medications was statistically more frequent in children with elevated PLMS. The prevalence of PLMI 〉 5 was 5% and the prevalence of periodic limb movement disorder (PLMD) was 0.3% in children referred to polysomnography. Ferritin levels did not differ. Conclusions We identified the prevalence of PLMD in a sleep medicine–referred population. We have also identified comorbidities and medications associated with elevated PLMI in children. No clinical trial
Type of Medium:
Online Resource
ISSN:
0161-8105
,
1550-9109
DOI:
10.1093/sleep/zsz221
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2019
detail.hit.zdb_id:
2056761-3
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