In:
Current Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 29, No. 4 ( 2022-02), p. 612-634
Abstract:
Chikungunya virus (CHIKV) is an Alphavirus (Togaviridae) responsible for
Chikungunya fever (CHIKF) that is mainly characterized by a severe polyarthralgia, in which it is transmitted by the bite of infected Aedes aegypti and Ae. albopictus mosquitoes.
Nowadays, there are no licensed vaccines or appr oved drugs to specifically treat this
viral disease. Structural viral proteins participate in key steps of its replication cycle, such as viral entry, membrane fusion, nucleocapsid assembly, and virus budding. In this context,
envelope E3-E2-E1 glycoproteins complex could be targeted for designing new drug candidates. In this review, aspects of the CHIKV entry mechanism are discussed to provide
insights into assisting the drug discovery process. Moreover, several naturals, naturebased and synthetic compounds, as well as repurposed drugs and virtual screening are also
explored as alternatives for developing CHIKV entry inhibitors. Finally, we provided a complementary analysis of studies involving inhibitors that were not explored by in silico
methods. Based on this, Phe118, Val179, and Lys181 were found to be the most frequent residues, being present in 89.6, 82.7, and 93.1% of complexes, respectively. Lastly, some
chemical aspects associated with interactions of these inhibitors and mature envelope E3- E2-E1 glycoproteins’ complex were discussed to provide data for scientists worldwide,
supporting their search for new inhibitors against this emerging arbovirus.
Type of Medium:
Online Resource
ISSN:
0929-8673
DOI:
10.2174/0929867328666210623165005
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2022
SSG:
15,3
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