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  • 1
    Online Resource
    Online Resource
    Can non-cholesterol sterols indicate the presence of specific dysregulation of cholesterol metabolism in patients with colorectal cancer?
    Elsevier BV ; 2022
    In:  Biochemical Pharmacology Vol. 196 ( 2022-02), p. 114595-
    Details
    In: Biochemical Pharmacology, Elsevier BV, Vol. 196 ( 2022-02), p. 114595-
    Type of Medium: Online Resource
    ISSN: 0006-2952
    URL: Article
    DOI: 10.1016/j.bcp.2021.114595
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 1496199-4
    SSG: 15,3
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  • 2
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    Biochemical and hematological parameters in the 1st trimester of pregnancy
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2023
    In:  Arhiv za farmaciju Vol. 73, No. 1 ( 2023), p. 62-73
    Details
    In: Arhiv za farmaciju, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 73, No. 1 ( 2023), p. 62-73
    Abstract: The 1st trimester of pregnancy is accompanied with changes in different biochemical and hematological parameters. Analyses scheduled to be performed in the 1st trimester are complete blood count, blood group, Rh factor and the double test. Many experts also suggest the determination of lipid status parameters as a routine analysis in the early pregnancy. Reliable data about maternal and fetal health can be obtained by the assessment of the above-mentioned parameters. They may be helpful in assessing the risk for pregnancy complication development and/or perinatal adverse outcomes.
    Type of Medium: Online Resource
    ISSN: 0004-1963 , 2217-8767
    Uniform Title: Biohemijski i hematološki parametri u prvom trimestru trudnoće
    URL: Article
    DOI: 10.5937/arhfarm73-41999
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2023
    SSG: 15,3
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  • 3
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    Cholesterol Metabolic Profiling of HDL in Women with Late-Onset Preeclampsia
    MDPI AG ; 2023
    In:  International Journal of Molecular Sciences Vol. 24, No. 14 ( 2023-07-12), p. 11357-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 24, No. 14 ( 2023-07-12), p. 11357-
    Abstract: A specific feature of dyslipidemia in pregnancy is increased high-density lipoprotein (HDL) cholesterol concentration, which is probably associated with maternal endothelium protection. However, preeclampsia is most often associated with low HDL cholesterol, and the mechanisms behind this change are scarcely explored. We aimed to investigate changes in HDL metabolism in risky pregnancies and those complicated by late-onset preeclampsia. We analyze cholesterol synthesis (cholesterol precursors: desmosterol, 7-dehydrocholesterol, and lathosterol) and absorption markers (phytosterols: campesterol and β-sitosterol) within HDL particles (NCSHDL), the activities of principal modulators of HDL cholesterol’s content, and major HDL functional proteins levels in mid and late pregnancy. On the basis of the pregnancy outcome, participants were classified into the risk group (RG) (70 women) and the preeclampsia group (PG) (20 women). HDL cholesterol was lower in PG in the second trimester compared to RG (p 〈 0.05) and followed by lower levels of cholesterol absorption markers (p 〈 0.001 for campesterolHDL and p 〈 0.05 for β-sitosterolHDL). Lowering of HDL cholesterol between trimesters in RG (p 〈 0.05) was accompanied by a decrease in HDL phytosterol content (p 〈 0.001), apolipoprotein A-I (apoA-I) concentration (p 〈 0.05), and paraoxonase 1 (PON1) (p 〈 0.001), lecithin–cholesterol acyltransferase (LCAT) (p 〈 0.05), and cholesterol ester transfer protein (CETP) activities (p 〈 0.05). These longitudinal changes were absent in PG. Development of late-onset preeclampsia is preceded by the appearance of lower HDL cholesterol and NCSHDL in the second trimester. We propose that reduced capacity for intestinal HDL synthesis, decreased LCAT activity, and impaired capacity for HDL-mediated cholesterol efflux could be the contributing mechanisms resulting in lower HDL cholesterol.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms241411357
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 4
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    Effects of Gestational Diabetes Mellitus on Cholesterol Metabolism in Women with High-Risk Pregnancies: Possible Implications for Neonatal Outcome
    MDPI AG ; 2022
    In:  Metabolites Vol. 12, No. 10 ( 2022-10-11), p. 959-
    Details
    In: Metabolites, MDPI AG, Vol. 12, No. 10 ( 2022-10-11), p. 959-
    Abstract: Metabolic disorders in pregnancy, particularly gestational diabetes mellitus (GDM), are associated with an increased risk for adverse pregnancy outcome and long-term cardiometabolic health of mother and child. This study analyzed changes of serum cholesterol synthesis and absorption markers during the course of high-risk pregnancies, with respect to the development of GDM. Possible associations of maternal lipid biomarkers with neonatal characteristics were also investigated. The study included 63 women with high risk for development of pregnancy complications. Size and proportions of small low-density (LDL) and high-density lipoprotein (HDL) particles were assessed across trimesters (T1–T3), as well as concentrations of cholesterol synthesis (lathosterol, desmosterol) and absorption markers (campesterol, β-sitosterol). During the study, 15 women developed GDM, while 48 had no complications (non-GDM). As compared to the non-GDM group, women with GDM had significantly higher triglycerides in each trimester, while having a lower HDL-C level in T3. In addition, they had significantly lower levels of β-sitosterol in T3 (p 〈 0.05). Cholesterol synthesis markers increased across trimesters in both groups. A decrease in serum β-sitosterol levels during the course of pregnancies affected by GDM was observed. The prevalence of small-sized HDL decreased in non-GDM, while in the GDM group remained unchanged across trimesters. Newborn’s size in the non-GDM group was significantly higher (p 〈 0.01) and inversely associated with proportions of both small, dense LDL and HDL particles (p 〈 0.05) in maternal plasma in T1. In conclusion, high-risk pregnancies affected by GDM are characterized by altered cholesterol absorption and HDL maturation. Advanced lipid testing may indicate disturbed lipid homeostasis in GDM.
    Type of Medium: Online Resource
    ISSN: 2218-1989
    URL: Article
    DOI: 10.3390/metabo12100959
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662251-8
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  • 5
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    Online Resource
    Lipoproteins and cholesterol homeostasis in paediatric nephrotic syndrome patients
    Croatian Society for Medical Biochemistry and Laboratory Medicine ; 2022
    In:  Biochemia medica Vol. 32, No. 2 ( 2022-06-15), p. 224-233
    Details
    In: Biochemia medica, Croatian Society for Medical Biochemistry and Laboratory Medicine, Vol. 32, No. 2 ( 2022-06-15), p. 224-233
    Abstract: The aim of this study was to investigate lipoprotein particle distributions and the likelihood of achieving cholesterol homeostasis in the remission phase of nephrotic syndrome (NS) in paediatric patients. We hypothesized that lipoprotein particle distributions moved toward less atherogenic profile and that cholesterol homeostasis was achieved. Thirty-three children, 2 to 9 years old with NS were recruited. Blood sampling took place both in the acute phase and during remission. Serum low-density lipoprotein particles (LDL) and high-density lipoprotein particles (HDL) were separated using non-denaturing polyacrylamide gradient gel (3-31%) electrophoresis. Serum non-cholesterols sterols (NCSs), desmosterol, lathosterol, 7-dehydrocholesterol (7-DHC), campesterol and β-sitosterol were measured by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). All patients had desirable serum HDL cholesterol concentrations during remission. The dominant lipoprotein diameters and LDL subclass distribution did not change significantly during follow-up. In contrast, HDL lipoprotein particle distribution shifted towards larger particles. The absolute concentration of desmosterol was significantly lower during remission (P = 0.023). β-sitosterol concentration markedly increased during remission (P = 0.005). Desmosterol/β-sitosterol (P 〈 0.001) and 7-DHC/β-sitosterol (P = 0.005) ratios significantly declined during disease remission. Favourable changes in the serum lipid profiles, HDL particle subclass distribution and cholesterol metabolism in paediatric patients with NS during remission took place. For the first time, we found that cholesterol homeostasis changed in favour of increased cholesterol absorption during disease remission. Nevertheless, complete cholesterol homeostasis was not achieved during disease remission.
    Type of Medium: Online Resource
    ISSN: 1846-7482 , 1330-0962
    URL: Journal
    URL: Article
    DOI: 10.11613/issn.1846-7482
    DOI: 10.11613/BM.2022.020706
    Language: Unknown
    Publisher: Croatian Society for Medical Biochemistry and Laboratory Medicine
    Publication Date: 2022
    detail.hit.zdb_id: 2280328-2
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  • 6
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    Antioxidant, anti-inflammatory, and anti-hyperlipidemic properties of the spelt grass juice
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2021
    In:  Hrana i ishrana Vol. 62, No. 1 ( 2021), p. 28-36
    Details
    In: Hrana i ishrana, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 62, No. 1 ( 2021), p. 28-36
    Abstract: Spelt is a grain rich in bioactive compounds - different phytochemicals, so it is often mentioned in the context of being beneficial to human health. We aimed to investigate the antioxidant, anti-inflammatory, and anti-hyperlipidemic properties of the spelt grass juice. Twenty volunteers consumed a beverage once a day, by dissolving one dose in 200 ml of still water, for 2 months. All individuals were clinically and biochemically examined. The individual profiles of LDL and HDL particles were determined by polyacrylamide gradient gel electrophoresis, while the concentrations of non-cholesterol sterols were measured using the gas chromatography - flame ionization detector. High-sensitivity Creactive protein (hsCRP) was measured using the commercially available kit. Concentrations of oxidative stress status parameters were measured spectrophotometrically. Though no change was observed in lipid profile parameters, values of coronary risk (CRI) (p 〈 0.05) and the atherogenic indexes (AI) (p 〈 0.05) after the supplementation were lower compared with values before the dietary intervention. After analyzing the markers of cholesterol synthesis and absorption, we only noticed a significant increase in campesterol concentrations (p 〈 0.05). Moreover, we found a statistically significant reduction in hsCRP concentrations in subjects who underwent spelt juice supplementation (p 〈 0.001). A significant decrease in PAB (p 〈 0.001), AOPP (p 〈 0.05) and PON1 (p 〈 0.001) was recorded after supplementation. On the other side, TAS values and concentration of SH groups were significantly higher after the dietary intervention (p 〈 0.001, both). We suggested a possible beneficial effect of the spelt grass supplementation on the overall lipid profile, the prooxidant-antioxidant balance, and inflammatory parameters.
    Type of Medium: Online Resource
    ISSN: 0018-6872 , 2560-452X
    Uniform Title: Antioksidativna, antiinflamatorna i anti-hiperlipidemična svojstva speltinog soka
    URL: Article
    DOI: 10.5937/hraIsh2101028A
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2021
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  • 7
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    Cardiometabolic and antioxidative effects of lyophilized goat whey supplementation
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2019
    In:  Hrana i ishrana Vol. 60, No. 2 ( 2019), p. 59-64
    Details
    In: Hrana i ishrana, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 60, No. 2 ( 2019), p. 59-64
    Type of Medium: Online Resource
    ISSN: 0018-6872 , 2560-452X
    Uniform Title: Kardiometabolički i antioksidativni efekti suplementacije liofiliziranom kozjom surutkom
    URL: Article
    DOI: 10.5937/hraIsh1902059G
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2019
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  • 8
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    PROMENE NAVIKA U ISHRANI MLADIH TOKOM COVID- 19 PANDEMIJE U REPUBLICI SRPSKOJ
    National and University Library of the Republic of Srpska ; 2021
    In:  SPORT I ZDRAVLJE Vol. 16, No. 1 ( 2021-10-10)
    Details
    In: SPORT I ZDRAVLJE, National and University Library of the Republic of Srpska, Vol. 16, No. 1 ( 2021-10-10)
    Abstract: Pandemija korona virusa dovela je do prekida rada u različitim delovima sveta i samim tim, izazvala brojne promene u načinu života ljudi, uključujući društvene interakcije, mogućnost bavljenja sportom, pa i sam način ishrane. Cilj istrazivanja bio je utvrditi, koliko je Covid- 19, uticao na promene načina ishrane, kod mlade kategorije ljudi. Istrazivanje je sprovedeno od januara do aprila 2021.godine, na ukupnom uzorku od 376 ispitanika iz kategorije studenata, sa prostora Republike Srpske. Za obradu dobijenih podataka je korišćen SPSS programski softver, verzija 23.00. Rezultati, dobijeni ANOVA analizom, pokazali su da većina ispitanika nije imala problem sa nabavkom hrane, ali jeste uočena veća potrosnja hrane tokom pandemije. Takodje, potvrdjeno je da ne postoje statisticki uočene razlike u promeni navika tokom pandemije, u odnosu na polnu strukturu ispitanika. Istrazivanjem se dokazalo, da krizna situacija pandemije, nije uticala na promenu intenziteta upraznjavanja fizickih aktivnosti. Rad ima širi drustveni i naucni znacaj, jer moze pomoci u sagledavanju promena ponasanja i navika omladine u toku kriznih situacija, kao sto je pandemija.
    Type of Medium: Online Resource
    ISSN: 1840-152X
    URL: Article
    DOI: 10.7251/SIZ2101025G
    Language: Unknown
    Publisher: National and University Library of the Republic of Srpska
    Publication Date: 2021
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  • 9
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    Non-Coding RNAs in Preeclampsia—Molecular Mechanisms and Diagnostic Potential
    MDPI AG ; 2021
    In:  International Journal of Molecular Sciences Vol. 22, No. 19 ( 2021-09-30), p. 10652-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 22, No. 19 ( 2021-09-30), p. 10652-
    Abstract: Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality worldwide. Defects in trophoblast invasion, differentiation of extravillous trophoblasts and spiral artery remodeling are key factors in PE development. Currently there are no predictive biomarkers clinically available for PE. Recent technological advancements empowered transcriptome exploration and led to the discovery of numerous non-coding RNA species of which microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are the most investigated. They are implicated in the regulation of numerous cellular functions, and as such are being extensively explored as potential biomarkers for various diseases. Altered expression of numerous lncRNAs and miRNAs in placenta has been related to pathophysiological processes that occur in preeclampsia. In the following text we offer summary of the latest knowledge of the molecular mechanism by which lnRNAs and miRNAs (focusing on the chromosome 19 miRNA cluster (C19MC)) contribute to pathophysiology of PE development and their potential utility as biomarkers of PE, with special focus on sample selection and techniques for the quantification of lncRNAs and miRNAs in maternal circulation.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms221910652
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 10
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    Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings
    MDPI AG ; 2022
    In:  International Journal of Environmental Research and Public Health Vol. 19, No. 22 ( 2022-11-14), p. 14995-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 19, No. 22 ( 2022-11-14), p. 14995-
    Abstract: Adiponectin (ADIPOQ) as both a regulator of metabolic homeostasis and a protein involved in immune response might be of particular interest to contemporary laboratory medicine, especially in terms of minimally invasive diagnostics. The diverse roles of ADIPOQ with regard to the immune and metabolic aspects of colorectal carcinogenesis have been proposed. However, the expression of its receptors ADIPOR1 and ADIPOR2 is scarcely explored in peripheral blood mononuclear cells (PBMCs). Moreover, ADIPORs’ relationships with the immune response mediator TNF-α have not been previously investigated in the PBMCs of CRC patients. This study used both in silico and observational case–control analyses with the aim of exploring the association of ADIPOR gene expression and ADIPOQ single nucleotide polymorphisms (SNPs) with the inflammatory marker TNF-α and lipid status parameters in patients with CRC. Publicly available transcriptomic datasets (GSE47756, GSE44076) obtained from analyses of monocytes and CRC tissue samples were employed for the in silico evaluation of ADIPORs’ specific genetic traits. GSE47756 and GSE44076 datasets were processed with GSEA software to provide a genetic fingertip of different signaling pathways associated with ADIPORs’ mRNA levels. The case–control aspect of the study included the PBMC samples of 73 patients diagnosed with CRC and 80 healthy volunteers. The PCR method was carried out for the PBMC gene expression analysis (ADIPOR1, ADIPOR2, TNF-α mRNA levels) and for the subjects’ genotyping (ADIPOQ rs266729, ADIPOR1 rs7539542). GSEA showed significant associations of ADIPOR mRNA expression with gene sets related to metabolic and immune homeostasis in both datasets. The case–control study revealed the association of ADIPOR1 rs7539542 with reduced lipid status parameters in CRC. In addition, PBMC ADIPOR1 mRNA levels decreased in CRC (p 〈 0.001), whereas ADIPOR2 mRNA did not differ between the groups (p = 0.442). A reduction in PBMC TNF-α mRNA levels was noted in CRC (p 〈 0.05). Our results indicate that ADIPOR1 and ADIPOR2 play a significant role in the alteration of both metabolic and immune homeostasis during the progression of CRC. For the first time, ADIPOR1 is shown to be a specific receptor for mediating ADIPOQ’s effects in the PBMCs of CRC patients.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph192214995
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2175195-X
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