In:
Clinical Nuclear Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 46, No. 3 ( 2021-3), p. 181-186
Kurzfassung:
The aim of this study was to compare retrospectively 18 F-DOPA PET/CT versus 68 Ga-DOTANOC PET/CT in a group of patients affected by midgut NET. Patients and Methods Patients with histologically proven grade 1 or grade 2 midgut NET were explored after injection of 150 MBq of 68 Ga-DOTANOC and 210 MBq of 18 F-DOPA. The PET/CTs were analyzed visually and semiquantitatively at the patient level, regional level (7 defined regions), and lesion level (maximum of 5 lesions/organ). The criterion standard was determined on the basis of histology and imaging follow-up. Results Thirty patients (17 males and 13 females; median age, 63.5 years [37–82 years]) were included. Both PET/CTs were negative in 3 patients and positive in 25 patients. PET/CTs were discordant in 2 patients, with 18 F-DOPA positive and 68 Ga-DOTANOC negative. 18 F-DOPA PET/CT detected more involved regions and more metastatic lesions than 68 Ga-DOTANOC PET/CT in 6 (20%) and 10 (33.3%) patients, respectively. Of the 81 confirmed affected regions, 77 (95%) were detected by 18 F-DOPA PET/CT and 71 (87.7%) by 68 Ga-DOTANOC PET/CT ( P 〈 0.0001). 18 F-DOPA PET/CT detected significantly more lesions (211/221) than 68 Ga-DOTANOC PET/CT (195/221), corresponding to a sensitivity of 95.5% and 88.2%, respectively ( P 〈 0.0001). Tumor-to-background ratios were more favorable in liver for 18 F-DOPA than for 68 Ga-DOTANOC. Interestingly, a correlation was found between 18 F-DOPA SUV max and tumor burden and especially with the number of regions involved by the disease ( P = 0.019). Conclusions 18 F-DOPA PET/CT is superior to 68 Ga-DOTANOC PET/CT for the detection of lesions, and when available, this tracer may be recommended as the first-line examination for an accurate staging of midgut NET.
Materialart:
Online-Ressource
ISSN:
1536-0229
,
0363-9762
DOI:
10.1097/RLU.0000000000003450
Sprache:
Englisch
Verlag:
Ovid Technologies (Wolters Kluwer Health)
Publikationsdatum:
2021
ZDB Id:
2045053-9
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