In:
Natural Product Communications, SAGE Publications, Vol. 14, No. 6 ( 2019-06), p. 1934578X1985881-
Abstract:
A new benzofurane 7-methoxy-2-(3-hydroxy-4-methoxyphenyl)-benzofuran-5-carboxylate (1) and 5 known compounds, such as propacin (2), hisbiscolatone A (3), heliclactone (4), rosmarinic acid (5), and syringaldehyde (6), were isolated from methanol extract of the Helicteres hirsuta stems. Their structures were elucidated by spectroscopic analysis as Nuclear Magnetic Resonance (NMR) and Mass Spectroscopy (MS) Furthermore, compounds 1 to 6 were evaluated for their cytotoxic activity against 4 human cancer cell lines such as Lu-1, MCF7, HepG2, and KB. The results showed that compound 2 exhibited moderate cytotoxic activity against Lu-1, MCF7, HepG2, and KB cell lines with IC 50 values of 43.97 ± 2.12, 46.53 ± 0.75, 52.63 ± 0.24, and 56.37 ± 1.04 µg/mL, respectively. This is the first report of compounds 2 to 6 from H. hirsuta.
Type of Medium:
Online Resource
ISSN:
1934-578X
,
1555-9475
DOI:
10.1177/1934578X19858814
Language:
English
Publisher:
SAGE Publications
Publication Date:
2019
detail.hit.zdb_id:
2430442-6
SSG:
15,3
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