In:
Journal of Biophotonics, Wiley, Vol. 7, No. 3-4 ( 2014-04), p. 254-265
Abstract:
FTIR spectroscopy is a powerful diagnostic tool that can also derive biochemical signatures of a wide range of cellular materials, such as cytology, histology, live cells, and biofluids. However, while classification is a well‐established subject, biomarker identification lacks standards and validation of its methods. Validation of biomarker identification methods is difficult because, unlike classification, there is usually no reference biomarker against which to test the biomarkers extracted by a method. In this paper, we propose a framework to assess and improve the stability of biomarkers derived by a method, and to compare biomarkers derived by different method set‐ups and between different methods by means of a proposed “biomarkers similarity index”. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Type of Medium:
Online Resource
ISSN:
1864-063X
,
1864-0648
DOI:
10.1002/jbio.201300190
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2403788-6
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