In:
Archiv der Pharmazie, Wiley, Vol. 353, No. 6 ( 2020-06)
Abstract:
In this study, three groups of adamantylphthalimides, bearing different substituents at the phthalimide moiety, N ‐(4′‐R 2 )phthalimidoadamantanes ( 1 – 7 ), 3‐[ N ‐(4′‐R 2 )phthalimido]‐1‐adamantanols ( 8 – 10 ), and 3‐[ N ‐(4′‐R 2 )phthalimido]adamantane‐1‐carboxylic acids ( 11 – 15 ), were synthesized and screened against tumor cells and viruses. The most potent compounds are not substituted at the adamantane and bear an OH or NH 2 substituent at the phthalimide (compounds 3 and 5 ). The antiproliferative activities of compounds 3 and 5 are in the micromolar range, much higher than the one of thalidomide. A minor antiviral activity against cytomegalovirus and varicella‐zoster virus was found for compounds 3 and 5 , but these compounds lacked selectivity. The results presented are important for the rational design of the next‐generation compounds with anticancer and antiviral activities.
Type of Medium:
Online Resource
ISSN:
0365-6233
,
1521-4184
DOI:
10.1002/ardp.202000024
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1496815-0
SSG:
15,3
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