In:
Journal of the Serbian Chemical Society, National Library of Serbia, Vol. 87, No. 2 ( 2022), p. 181-192
Kurzfassung:
In this paper, the previously synthesized Cu(II) complex ([CuL1(N3)
(CH3OH)]BF4) with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)-
hydrazinyl)ethan-1-aminium chloride, has been characterized and its
biological activity has been studied in detail. The Cu(II) complex consists
of ligand coordinated in a deprotonated, formally neutral zwitter-ionic
form, via NNO atoms, one azido ligand and one methanol molecule. The Cu(II)
complex was selected due to results of the cytotoxic activity, the brine
shrimp test and DPPH radical scavenging activity, which were previously
performed. The effects of Cu(II) complex on cell cycle phase distribution of
cervical adenocarcinoma HeLa cells were investigated in order to examine
the mechanisms of its anticancer activity. The measurement of intracellular
ROS levels in HeLa and HaCaT cell lines were evaluated in order to explore
their possible generation and the role in cytotoxic activity. The possible
anti-invasive and anti-angiogenic properties of Cu(II) complex were
evaluated. DNA binding experiments, including fluorescence displacement
study and DNA cleavage experiments, were performed in order to obtain
information on the type of DNA-metal complex interactions.
Materialart:
Online-Ressource
ISSN:
0352-5139
,
1820-7421
DOI:
10.2298/JSC211203114S
Sprache:
Englisch
Verlag:
National Library of Serbia
Publikationsdatum:
2022
ZDB Id:
2030173-X
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