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  • 1
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    Abstract 4918: Is Livin a protagonist of mucinous adenocarcinoma histology in colorectal cancer
    American Association for Cancer Research (AACR) ; 2017
    In:  Cancer Research Vol. 77, No. 13_Supplement ( 2017-07-01), p. 4918-4918
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 77, No. 13_Supplement ( 2017-07-01), p. 4918-4918
    Abstract: The mechanism of cancer resistance to chemotherapy regimen remains uncertain. Colorectal mucinous adenocarcinoma is one of the distinct histological subtypes of the disease implicated in chemotherapeutic resistance associated with nodal and peritoneal metastases and worse disease-free survival as an index of poor prognosis. One of the important acquired capabilities used by the cancer cells to resist anticancer therapies is evasion of apoptosis possibly via inhibitor of apoptosis proteins for which Livin is one. This protein contains baculoviral IAP repeat domains in addition to a RING finger, a protein-protein motif important for binding and inhibition of active caspases that interfere with intrinsic and/or extrinsic pathway and the ensuing blockade of apoptosis. Thus, understanding the molecular events on how cancer cells of mucinous histology evade apoptotic death may provide a novel paradigm for a molecular targeted therapy in the management of colorectal mucinous adenocarcinoma. In this study, the expression pattern and prognostic value of IAP family protein, Livin, in colorectal cancer patients with mucinous histology pre and post-chemotherapy regimen was investigated. Tissue sections from advanced stage colorectal cancer patients who were treated or untreated with neo-adjuvant FOLFOX chemotherapy before curative resection were included in this study. The tissue sections were grouped according to colorectal adenocarcinomas showing mucinous histology and non-mucinous component. Histological study including Haematoxylin and Eosin, and immunohistochemistry for Anti-Livin and DNA mismatched repair proteins were carried out. Immunofluorescence study was performed to clarify the expression pattern of the protein using Anti-Livin antibody. Protein expression quantification study was also used. Results show significant cytoplasmic localisation and expression of Livin protein in the colorectal cancer cells. The Livin protein expression was found to be increased by more than a one-fold post-chemotherapy treatment when compared with pre-chemotherapy treated patients with mucinous histology of colorectal cancer. Younger patients were found to have a greater probability of colorectal mucinous adenocarcinoma diagnosis and worse prognosis. Our findings show that Livin-induced inhibition of apoptosis activity can be a target for novel approaches to treatment and prevention of chemotherapy associated drug resistance in mucinous histology colorectal cancer since Livin overexpression has been associated with metastases and worse disease-free survival. More study is needed Citation Format: Mohammed Faruk, Abdulmumini Hassan Rafindadi, Sani Ibrahim, Surajo Mohammed Aminu, Surajo Mohammed Aminu, Ahmed Adamu, Ahmed Adamu, Yawale Iliyasu, Adamu Abdullahi, Mohammed Sani Shehu, Abdullahi Mohammed, John Idoko, Abdullahi Jibril Randawa, Abdullahi Jibril Randawa, Atara Ntekim, Saad Aliyu Ahmed, Aishatu Suleiman Maude, Almustapha Aliyu Liman, Abubakar Sani, Khalid Zahir Shah, Yahaya Ukwenya, Yahaya Ukwenya, Cheh Augustine Awasum, Kasimu Umar Adoke, James Olowu Enemari, James Olowu Enemari, James Olowu Enemari, Andrew Jonathan Nok. Is Livin a protagonist of mucinous adenocarcinoma histology in colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4918. doi:10.1158/1538-7445.AM2017-4918
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2017-4918
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2017
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  • 2
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    Abstract B71: First ten malignancies by ranking from a population of rural Africans in Zaria, Nigeria: A fourteen years review and report
    American Association for Cancer Research (AACR) ; 2017
    In:  Cancer Epidemiology, Biomarkers & Prevention Vol. 26, No. 2_Supplement ( 2017-02-01), p. B71-B71
    Details
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 26, No. 2_Supplement ( 2017-02-01), p. B71-B71
    Abstract: Every environment is noted for its variability in incidences of various malignancies and subtypes. The objective of this study is to analyze the trend of malignant tumors in a population of rural Africans attending Ahmadu Bello University Teaching Hospital Zaria, Nigeria with particular emphasis on the first ten most frequently diagnosed cancers over a period of 14 consecutive years (2001-2014). Histologically diagnosed cancers in the various cancer registries of the ABUTH Zaria were included in this study. The ten most commonly presenting cancers were extracted and their demographic characteristics and other relevant clinical data documented using a standardized questionnaire. The data obtained were analyzed using SPSS software version 20.0. There were 6,553 histologically diagnosed cancers over 14 years in Ahmadu Bello Unibersity Teaching Hospital Zaria with the following in descending order: Cervical cancer 1042 (15.90%), Breast cancer 788 (12.02%), Prostate cancer 496 (7.56%), Colorectal cancer 360 (5.49%), Lymphoma 306 (4.66%), Eye/orbit cancer 170 (2.59%), Bladder cancer 169 (2.45%), Nasopharyngeal cancer 139 (2.12%), Ovarian cancers 94 (1.43%), and Liver cancer 52 (0.79%). Cervical cancer tops the list as the most frequently diagnosed cancer however, this should be noted that it is a cancer exclusive to females so also breast cancers though rarely males may present with breast cancer. Prostate cancer is a male exclusive disease therefore the percentage would have been higher if the diagnosis would have excluded the females. Of the ten most frequently diagnosed cancers, liver cancer is the tenth despite the fact that complications of viral hepatitidis are known to facilitate liver carcinogenesis and the prevalence of hepatitis C and B in the Nigerian population is 5 and 20 respectively. Citation Format: Abdulmumini Hassan Rafindadi, Surajo Mohammed Aminu, Mohammed Faruk, Yawale Iliyasu, Abdullahi Mohammed, Sani Ibrahim, Ahmed Adamu, Mohammed Sani Shehu, Abdullahi Jubril Randawa, Adamu Abdullahi, Saad Aliyu Ahmed, Maitama Yusuf Hussaini, Danladi Amodu Ameh, Ukwenya Yahaya, John Idoko, Oguntayo Olanrewaju Adekunle, Almustapha Aliyu Liman, Abdulkadir Lawal Rafindadi, Aisha Maude Suleiman, Jigo Dangude Yaro, Ahmad Bello, Bello Kumo. First ten malignancies by ranking from a population of rural Africans in Zaria, Nigeria: A fourteen years review and report. [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr B71.
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    URL: Article
    DOI: 10.1158/1538-7755.DISP16-B71
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2017
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  • 3
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    Abstract B27: Assessment of chemotherapeutic responses to neoadjuvant FOLFOX and Aspirin on BIRC7 in colorectal adenocarcinoma cells induced in Albino rats
    American Association for Cancer Research (AACR) ; 2017
    In:  Clinical Cancer Research Vol. 23, No. 1_Supplement ( 2017-01-01), p. B27-B27
    Details
    In: Clinical Cancer Research, American Association for Cancer Research (AACR), Vol. 23, No. 1_Supplement ( 2017-01-01), p. B27-B27
    Abstract: Chemotherapeutic resistance is a problem in the management of malignant tumors especially colorectal adenocarcinoma. Overexpression of Baculoviral IAP repeat-containing protein-7 (BIRC7) was previously reported by this study group to limit the cytotoxic efficacy of neoadjuvant folinic acid, 5-fluorouracil and oxaliplatin (FOLFOX) chemotherapy regimen on human colorectal cancer cells in-vivo. And a significant inhibitory effect of Aspirin on the BIRC7 protein in p53 mutant SW480 colon cancer cells in-vitro was also found. Our aim now is to access the efficacy of the addition of Aspirin to neoadjuvant FOLFOX-chemotherapy on colorectal cancer cells in-vivo using the N-methyl-N-nitrosourea (NMU) carcinogen-induced model on albino rats per rectum. A total of 180 male Albino rats whose weight falls between 110-150g will be used. They will be grouped into 18 sets of 10 rats each and a three staged study will be performed. Namely, assessment of health parameters before the cancer induction, assessments on confirmation of cancer induction and assessments after chemotherapeutic intervention. The chemotherapeutic intervention will be further subdivided into mono, bi or tri therapy in various combinations with and without the addition of the Aspirin. The addition of Aspirin to the chemotherapy regimen will be further divided into concurrent and sequential addition. NMU will be administered at a dose of 2 mg/kg intra rectally every other day until the development of colorectal cancer which, will be confirmed by barium enema and histological analysis. Aspirin will be administered at a dose of 25 mg/kg or 12.5 mg/kg. Folinic acid will be administered at a dose of 7 mg/kg or 3.5 mg/kg intraperitoneally (i.p). Oxaliplatin will be dministered at a dose of 3 mg/kg or 1.5 mg/kg i.p. And 5-FU will be administered at a dose of 50 mg/kg or 25 mg/kg i.p. The animals' hemogram and other pertinent investigations will be done ultimately including culling for histological assessment of tumors. The tumors will be processed for H & E histological analysis, immunohistochemistry, immunofluorescence, ELISA and immunoblot using Anti-BIRC7, COX-2, NFK-B, P53, Annexin, MSH2, MSH6, PMS2, and MLH1 antibodies. Findings show that at full sequential dose of Aspirin with chemotherapy there was absence of both significant BIRC7 expression and histologically residual detectable tumor in the colon of the Albino rats. Furthermore, results from the concurrent treatment of Aspirin and FOLFOX in full dose compound to half dose of both sequential and concurrent show that there was significant tumor regression when compared with the untreated colon tumor bearing Albino Rats. The study also shows a survival advantage of the group of Albino rats treated sequentially compared other groups. The study showed that Aspirin given at full therapeutic dose prior to neoadjuvant chemotherapy makes the tumor cells highly chemosensitive and may have a role in the finding of having no detectable cancer cells in the colon and also reduced BIRC7 expression. By implication, Aspirin primes the colorectal cancer cells for neoadjuvant chemotherapeutic efficacy and this may be important for management of colorectal cancer patients. Citation Format: Mohammed Faruk, Sani Ibrahim, Surajo Mohammed Aminu, Adamu Abdullahi, Ahmed Adamu, Yawale Iliyasu, Mohammed Shehu Shehu, John Idoko, Abdullahi Jibril Randawa, Atara Ntekim, Saad Aliyu Ahmed, Abubakar Sani, Khalid Zahir Shah, Yahaya Ukwenya, Cheh Augustine Awasum, Kasimu Umar Adoke, Andrew Jonathan Nok. Assessment of chemotherapeutic responses to neoadjuvant FOLFOX and Aspirin on BIRC7 in colorectal adenocarcinoma cells induced in Albino rats. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Targeting the Vulnerabilities of Cancer; May 16-19, 2016; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(1_Suppl):Abstract nr B27.
    Type of Medium: Online Resource
    ISSN: 1078-0432 , 1557-3265
    URL: Article
    DOI: 10.1158/1557-3265.PMCCAVULN16-B27
    RVK:
    XA 36791
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2017
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  • 4
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    Prognostic significance of BIRC7/Livin, Bcl-2, p53, Annexin V, PD-L1, DARC, MSH2 and PMS2 in colorectal cancer treated with FOLFOX chemotherapy with or without aspirin
    Public Library of Science (PLoS) ; 2021
    In:  PLOS ONE Vol. 16, No. 1 ( 2021-1-19), p. e0245581-
    Details
    In: PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 1 ( 2021-1-19), p. e0245581-
    Abstract: Evasion of apoptosis is associated with treatment resistance and metastasis in colorectal cancer (CRC). Various cellular processes are associated with evasion of apoptosis. These include overexpression of pro-apoptotic proteins (including p53 and PD-L1), anti-apoptotic proteins (BIRC7/Livin and Bcl-2), chemokine receptors (including DARC), and dysregulation of DNA mismatch repair proteins (including MSH2 and PMS2). The aim of this study was to determine the effect of folinic acid, 5-FU and oxaliplatin (FOLFOX) as a single agent and aspirin plus FOLFOX in various combinations on the aforementioned proteins in human CRC, SW480 cell line and rat models of N-Methyl-N-Nitrosourea (NMU)-induced CRC. In addition, effects of the NMU-induced CRC and chemotherapeutic regimens on haematological and biochemical parameters in the rat models were studied. Immunohistochemistry, immunofluorescence and immunoblot techniques were used to study the expression pattern of the related proteins in the human CRC cells pre- and post-treatment. Double contrast barium enema, post-mortem examination and histological analyses were used to confirm tumour growth and the effect of the treatment in vivo in rat models. Notably, we found in human mucinous CRC, a significant increase in expression of the BIRC7/Livin post-FOLFOX treatment compared with pre-treatment ( p = 0.0001). This increase provides new insights into the prognostic role of BIRC7/Livin in evasion of apoptosis and facilitation of treatment resistance, local recurrence and metastasis particularly among mucinous CRCs post-FOLFOX chemotherapy. These poor prognostic features in the CRC may be further compounded by the significant suppression of DARC, PD-L1, PMS2 and overexpression of MSH2 and anti-apoptotic Bcl-2 and p53 proteins observed in our study (p 〈 0.05). Importantly, we found a significant reduction in expression of BIRC7/Livin and reactivation of DARC and PD-L1 with a surge in Annexin V expression in rat models of CRC cells post-treatment with a sequential dose of aspirin plus FOLFOX compared with other treatments in vivo ( p 〈 0.05). The mechanistic rational of these effects underscores the importance of expanded concept of possible aspirin combination therapy with FOLFOX sequentially in future CRC management. Validation of our findings through randomized clinical trials of aspirin plus FOLFOX sequentially in patients with CRC is therefore warranted.
    Type of Medium: Online Resource
    ISSN: 1932-6203
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    DOI: 10.1371/journal.pone.0245581
    DOI: 10.1371/journal.pone.0245581.g001
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    DOI: 10.1371/journal.pone.0245581.r001
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    Language: English
    Publisher: Public Library of Science (PLoS)
    Publication Date: 2021
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  • 5
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    Abstract A27: Fortification of dietary fiber-rich foodstuffs with Aspirin and its effect on colorectal carcinogenesis in rats
    American Association for Cancer Research (AACR) ; 2017
    In:  Cancer Research Vol. 77, No. 3_Supplement ( 2017-02-01), p. A27-A27
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 77, No. 3_Supplement ( 2017-02-01), p. A27-A27
    Abstract: Dietary fiber (DF), the fermentation substrates for colonic bacteria, has acquired a crucial status in protection against colorectal cancer. DF consists of mucilage, beta-glucans and pectin (soluble fiber) and cellulose, hemicelluloses and lignin (insoluble fiber) which, are cross-linked with proteins and phenolic compounds. DF improves optimal health through fecal quality, quantity and decreased carcinogenic colonic bacterial metabolites. One of the physico-chemical properties of DF attributed to these important health functions is the natural presence of salicylic acid (SA), an active component of Aspirin in our foodstuffs. However, the presence of SA has been recently reported to be gradually diminishing from our foodstuffs as a result of manmade activity. A large number of studies support the effectiveness of Aspirin in inhibition of colorectal cancer cells growth in-vitro and in-vivo. DF is not currently fortified with Aspirin, nor have the effects of Aspirin fortification on physico-chemical properties of DF been thoroughly studied. Of note, gastrointestinal bleeding is one of the effects associated with high dose aspirin use. This research aims to assess the efficacy of fortification of DF-rich foodstuffs with Aspirin in-vivo using the N-methyl-N-nitrosourea carcinogen-induced model of colorectal cancer in rats, with emphasis on the mechanism of biologic action. A total of 30 male Albino rats whose weight falls between 110-150g were used. They were grouped into 6 sets of 5 rats each and a soluble and insoluble DF feeding intervention was systematically employed in various combinations with Aspirin (1600mg/kg diet) and without Aspirin fortification for 80 days. NMU was administered at a dose of 2 mg/kg intra rectally every other day for 60 days until the development of colorectal cancer which, was confirmed by barium enema and histological analysis. Hemogram and other pertinent investigations were done ultimately including histological assessment of tumors. The tumors were processed for histological analysis and immunohistochemistry using Anti-p53 and Anti-Bcl-2 antibodies. Findings show no histologically detectable colorectal tumor in the group of rats fed with Aspirin-fortified mixture of soluble and insoluble DF foodstuffs. There was a considerable tumor regression in the group fed with Aspirin-fortified soluble/insoluble DF when compared to non-fortified group. The results show up-regulation of p53 and down-regulation of Bcl-2 proteins in Aspirin-fortified DF fed rats when compared with non-fortified group (p & lt;0.05). These results imply that DF fortification with Aspirin at low dose may serve as a possible preventive measure against colorectal cancer especially in tumor prone individuals. There is a need for further research. Note: This abstract was not presented at the conference. Citation Format: Mohammed Faruk, Abdulmumini Hassan Rafindadi, Sani Ibrahim, Surajo Mohammed Aminu, Ahmed Adamu, Yawale Iliyasu, John Idoko, Mohammed Sani Shehu, Adamu Abdullahi, Abdullahi Jubril Randawa, Atara Ntekim, Saad Aliyu Ahmed, Cheh Augustine Awasum, Kasimu Adoke, Andrew Jonathan Nok. Fortification of dietary fiber-rich foodstuffs with Aspirin and its effect on colorectal carcinogenesis in rats. [abstract]. In: Proceedings of the AACR Special Conference on Colorectal Cancer: From Initiation to Outcomes; 2016 Sep 17-20; Tampa, FL. Philadelphia (PA): AACR; Cancer Res 2017;77(3 Suppl):Abstract nr A27.
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.CRC16-A27
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2017
    detail.hit.zdb_id: 2036785-5
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  • 6
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    An analysis of dietary fiber and fecal fiber components including pH in rural Africans with colorectal cancer
    Korean Association for the Study of Intestinal Diseases ; 2018
    In:  Intestinal Research Vol. 16, No. 1 ( 2018), p. 99-
    Details
    In: Intestinal Research, Korean Association for the Study of Intestinal Diseases, Vol. 16, No. 1 ( 2018), p. 99-
    Type of Medium: Online Resource
    ISSN: 1598-9100 , 2288-1956
    URL: Article
    DOI: 10.5217/ir.2018.16.1.99
    Language: English
    Publisher: Korean Association for the Study of Intestinal Diseases
    Publication Date: 2018
    detail.hit.zdb_id: 3018469-1
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  • 7
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    Abstract 2638: Overexpressions of cortisol, annexin V and Lost in expression of PD-L1 and DARC proteins are associated with aggressive prostate cancer phenotypes in Black men: A CaPTC Cohort Study
    American Association for Cancer Research (AACR) ; 2018
    In:  Cancer Research Vol. 78, No. 13_Supplement ( 2018-07-01), p. 2638-2638
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 78, No. 13_Supplement ( 2018-07-01), p. 2638-2638
    Abstract: Prostate cancer (CaP) is the most common male gender cancer and present with a 5-year prevalence, incidence and mortality rate in Nigerian Black men. There is disproportionate prevalence and poor understanding of CaP in Black men globally. The Prostate Cancer Transatlantic Consortium (CaPTC) has documented significant CaP burden among Nigerian black men in Nigeria and in the Diaspora. Notably, African ancestry is one of the most important risk factors of CaP globally. Increased levels of cortisol, a stress-related catabolic hormone is significantly associated to prostate specific antigen and poor prognosis in prostate cancer patients. Cortisol causes degradation of muscle proteins into amino-acids. Amino acids such as leucine, serves as a source of fuel for aggressive prostate cancer cells in a Warburg effect model through the L-amino acid transporters (LATs). The annexins are calcium and phospholipid binding proteins implicated in cancer development and progression. Overexpression of annexin 1 is one of the mechanisms by which cortisol inhibit inflammation. Annexin V has a high affinity to phosphatidylserine and play important role of inhibiting engulfment of apoptotic cells by macrophages to increase the immunogenicity of tumor cells undergoing apoptosis. PD-L1 is an important membrane-bound costimulatory molecule that inhibits immune responses through its receptor, PD-1. Overexpression of PD-L1 results to cancer cells aggressively evading the host immune system. The Duffy Antigen/Receptor for Chemokines (DARC) is a 7-transmembrane protein atypical chemokine receptor expressed on erythrocytes and vascular endothelial cells that binds to and clears angiogenic chemokines. Expression pattern of DARC is associated to cancer growth and metastasis. In this study, we report the expression pattern of tissue Cortisol, Annexin V, PD-L1 and DARC proteins in relationship to Gleason score in Nigerian Black men with Prostate cancer using immunohistochemistry and immunofluorescence. In addition, we assessed salivary cortisol levels by enzyme immunoassay and physical activity by a standardized CaPTC-AC3-MADCaP (C.A.M) CaP measures from 500 subjects recruited by via CaPTC cohort. Results showed significant expression of tissue and salivary cortisol in the CaP patients compared to the normal subjects (p & gt; 0.05). The Tissue cortisol protein expression was higher in CaP cases with Gleason score 8. There was significant overexpression of Annexin protein in virtually the prostate cancer samples studied. We found a negative expression of PD-L1 and DARC proteins in all the CaP tissues studied. Cortisol and Annexin may serve as an important biomarker for prostate cancer diagnosis and prognosis in Nigerian Blacks. Citation Format: Faruk Mohammed, Folakemi T. Odedina, Sani Ibrahim, Abdulmumini Hassan Rafindadi, Ahmed Adamu, Abdullahi Adamu, Ahmad Bello, Surajo Mohammed Aminu, John Idoko, Aishatu Maude Suleiman, Solomon O. Rotimi, Ernie Kaninjing, Getachew A. Dagne, Clayton Yates, Yawale Iliyasu, Nissa Askins, Iya Eze Bassey, Renee Reams, Abdullahi Mohammad, Hussaini Yusuf Maitama, Dauda Maigatari, Mohammed Sani Shehu, Cheh Augustine Awasum, Abdulkadir Lawal Rafinadadi, Danladi Amodu Ameh, Serah Adewunmi, Ruth Agaba, Haruna Mohammad Muktar, Ahmad Mai, Saad Aliyu Ahmed, Ahmad Bello Kumo, Kasimu Umar Adoke, Ahmad Tijjani Lawal, Ahmad Muhammad, Omolora Fatiregun, Sunday Atawodi, Shehu Akuyam, Yusuf Abdulrashid, Mubarak Liman, Aliyu Muhammad, Abidemi Omonisi, Rebecca Gali, Hassan Dogo, Nkegoum Blaise, Anthonia Sowunmi, Titilola Akinremi, Emeka J. Iweala, Jigo Dangude Yaro, Badejo Adebukola Catherine, Akinwumi Oluwole Komolafe. Overexpressions of cortisol, annexin V and Lost in expression of PD-L1 and DARC proteins are associated with aggressive prostate cancer phenotypes in Black men: A CaPTC Cohort Study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2638.
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2018-2638
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2018
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    Displaced Persons in North-Eastern Nigeria: Causes, Effects and the Role of Social Workers
    Horizon Research Publishing Co., Ltd. ; 2020
    In:  Sociology and Anthropology Vol. 8, No. 3 ( 2020-5), p. 57-65
    Details
    In: Sociology and Anthropology, Horizon Research Publishing Co., Ltd., Vol. 8, No. 3 ( 2020-5), p. 57-65
    Type of Medium: Online Resource
    ISSN: 2331-6179 , 2331-6187
    URL: Article
    DOI: 10.13189/sa.2020.080301
    Language: English
    Publisher: Horizon Research Publishing Co., Ltd.
    Publication Date: 2020
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    Prevalence of Hospital Associated Infections and Health Care Workers Compliance with Hand Hygiene Practices in a Tertiary Hospital in Sokoto, Nigeria
    Nigerian Medical Association Sokoto State Branch ; 2021
    In:  Annals of Basic and Medical Sciences Vol. 2, No. 1 ( 2021-06-30)
    Details
    In: Annals of Basic and Medical Sciences, Nigerian Medical Association Sokoto State Branch, Vol. 2, No. 1 ( 2021-06-30)
    Abstract: Background: Hospital associated infections (HAIs) remain a significant cause of morbidity and mortality. And despite the simplicity of hand hygiene practice, an important preventive measure that has been proven to reduce the risk of acquiring and transmitting HAIs, Health care workers (HCW) compliance with the recommendations is of serious concern. Aim: The aim of this study was to determine the prevalence of hospital associated infections and HCWs compliance with hand hygiene practice in a tertiary hospital. Methods and material: This was a hospital-based descriptive cross-sectional study among 110 patients on admission selected using universal sampling, and 377 HCWs selected using a multistage sampling technique. Data collected with self-administered questionnaire for HCWs, interviewer-administered proforma for the patients and data extraction sheet for laboratory analysis. Data analyzed for descriptive statistics using SPSS version 20.0. Results: Patients' mean age was 32.8, IQR: 10.5-37.9 years. Majority, 56(50.9%) were females; Hausa/Fulani, 91(82.7%) and 37(33.6%) had only Qur'anic education while only 20(18.2%) had tertiary education. Health care workers' mean age was 31.8 5.3 years. Majority 227(60.2%) are females, and 267(71.8%) of the participants have received training on hospital infection control. Overall prevalence of HAIs was 42.7%, highest in surgical unit. Commonest HAIs being blood stream infections, and the least, Health Care Associated Pneumonia. Most of the infections were due to Staphylococcus aureus, 22(46.8%) and Pseudomonas aeruginosa, 14(29.8%). Highest hand hygiene practice was reported after contact with body fluid and highest non-compliance reported was before touching patient. Hand hygiene compliance rate was 49.6% and main reasons to non-compliance were high work load, lack of running water and soap, and regular use of hand gloves. Conclusions: Prevalence of HAIs was reportedly high, and low hand hygiene compliance and rate despite majority of the HCWs having received training on Hospital infection control. To reduce the prevalence and the associated burden of HAIs, there is need to put in measures to improve compliance to quality hand hygiene practice by health workers.
    Type of Medium: Online Resource
    ISSN: 2782-7550 , 2782-7542
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.51658/ABMS.202121
    DOI: 10.51658/ABMS
    DOI: 10.51658/ABMS.202121.6
    Language: Unknown
    Publisher: Nigerian Medical Association Sokoto State Branch
    Publication Date: 2021
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