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  • 1
    Online Resource
    Online Resource
    Estrogenic Effect of Salvia officinalis Extract on Reproductive Function of Female Mice and Identification of Its Phenolic Content
    Bentham Science Publishers Ltd. ; 2021
    In:  Combinatorial Chemistry & High Throughput Screening Vol. 24, No. 10 ( 2021-09-14), p. 1654-1663
    Details
    In: Combinatorial Chemistry & High Throughput Screening, Bentham Science Publishers Ltd., Vol. 24, No. 10 ( 2021-09-14), p. 1654-1663
    Abstract: Natural Phytoestrogens present in plants are effective hormonal replacement therapy. They are converted to estrogenic substances in the gastrointestinal tract, which is considered as the natural alternative to estrogen substitute treatment for postmenopausal women. Aim and Objective: Salvia officinalis, a herb traditionally used to ameliorate postmenopausal complications, can provide a safe alternative to synthetic pharmaceuticals for the treatment of menopause. Therefore, it is conceivable to detect the possible estrogenic effect of Salvia Officinalis extract as an estrogen replacement therapy in female mice. Methods: Phytochemical, pharmacological, and immune histopathological techniques are adopted in this study. HPLC is used for the identification of extracted constituents of sage herb. The uterotrophic activity of the extract was determined in immature female mice. Moreover, the mean thickness and luminal epithelium and the photomicrographs of the luminal epithelium of the uterus were also studied. Results: HPLC revealed that quercetin is the major extracted constituent (28.6%) of the total components. Saliva officinalis extract produced a significant increase in the uterine dry weight of equal potency to estrogen. The uterus exhibited a significant increase in luminal epithelial cell height (43.3 ± 6.1μm and 36.5 ± 2.5μm) for estradiol and sage extract, respectively, compared with the control group (18.2 ± 3.5μm). Furthermore, the endometrium showed the lining epithelium formed of a single layer of columnar epithelium. The stroma seemed more voluminous with dilated vasculature. Conversely, the myometrium within the uterus was not affected in any of the experimental groups. Conclusion: The sage herbs induced proliferative changes in the uteri of treated mice, which suggest possible estrogenic properties. Saliva officinalis extract can be used as a hormonal replacement for women during menopause and could be further explored for contraceptive use.
    Type of Medium: Online Resource
    ISSN: 1386-2073
    URL: Article
    DOI: 10.2174/1386207323666200811095527
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2021
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Eco-friendly approach to decrease the harmful effects of untreated wastewater on growth, yield, biochemical constituents, and heavy metal contents of carrot (Daucus carota L.)
    Springer Science and Business Media LLC ; 2024
    In:  Environmental Science and Pollution Research Vol. 31, No. 9 ( 2024-01-25), p. 14043-14058
    Details
    In: Environmental Science and Pollution Research, Springer Science and Business Media LLC, Vol. 31, No. 9 ( 2024-01-25), p. 14043-14058
    Type of Medium: Online Resource
    ISSN: 1614-7499
    URL: Article
    DOI: 10.1007/s11356-024-31869-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2024
    detail.hit.zdb_id: 2014192-0
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  • 3
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    Online Resource
    Alleviate the Drought Stress on Triticum aestivum L. Using the Algal Extracts of Sargassum latifolium and Corallina elongate Versus the Commercial Algal Products
    MDPI AG ; 2022
    In:  Life Vol. 12, No. 11 ( 2022-11-01), p. 1757-
    Details
    In: Life, MDPI AG, Vol. 12, No. 11 ( 2022-11-01), p. 1757-
    Abstract: Herein, two seaweed extracts (Sargassum latifolium and Corallina elongate), and two commercial seaweed products (Canada power and Oligo-X) with a concentration of 5% were used to alleviate the drought stress on wheat plants. The extract of C. elongate had the highest capacity to ameliorate the deleterious effects of water scarcity followed by S. latifolium and the commercial products. The drought stress reduced wheat shoots length and the contents of pigments (chlorophyll and carotenoids), carbohydrates, and proteins. While the highest increment in the total carbohydrates and protein contents of the wheat shoot after two stages, 37-and 67-days-old, were noted in drought-stressed plants treated with C. elongate extract with values of (34.6% and 22.8%) and (51.9% and 39.5%), respectively, compared to unstressed plants. Decreasing the activity of antioxidant enzymes, peroxidase, superoxidase dismutase, and polyphenol oxidase in drought-stressed plants treated with algal extracts indicated amelioration of the response actions. Analysis of phytohormones in wheat plants exhibited increasing GA3 and IAA contents with percentages of (20.3–13.8%) and (72.7–25%), respectively. Interestingly, all morphological and metabolic characteristics of yield were improved due to the algal treatments compared with untreated drought-stressed plants. Overall, the algal extracts, especially those from seaweed of C. elongate, could represent a sustainable candidate to overcome the damage effects of water deficiency in the wheat plant.
    Type of Medium: Online Resource
    ISSN: 2075-1729
    URL: Article
    DOI: 10.3390/life12111757
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662250-6
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  • 4
    Online Resource
    Online Resource
    Ameliorative effect of micro-algal and medicinal plants on some biochemical properties of bean plants under salinity stress
    BioResources ; 2023
    In:  BioResources Vol. 18, No. 3 ( 2023-7-25), p. 6142-6154
    Details
    In: BioResources, BioResources, Vol. 18, No. 3 ( 2023-7-25), p. 6142-6154
    Abstract: This study was conducted to examine the ameliorative effects of foliar application of some micro-algal (Chlorella vulgaris and Spirulina platensis) and some medicinal plant leaves (Salix alba, Psidium guajava, and Olea europaea) extracts on Phaseolus vulgaris (Bean) under salinity stress. On a loamy soil, a pots trial was carried out on bean plants grown under salinity stress. Growth characteristics, pigments, osmolytes, total phenol, and antioxidant enzyme contents were determined. S. platensis extract application showed the greatest improvement in shoot length and fresh weight of shoot, which rose 23.5% and 65.1%, respectively compared to the control. The utilized bio-stimulants, particularly S. platensis extracts, remarkably increased the chlorophyll content compared to the control under salinity stress. The photosynthetic pigment, soluble sugars, and soluble protein levels were strengthened by foliar application of bio-stimulant extract. Proline and antioxidant enzyme levels are significantly reduced using algal and plant extracts treatment. These findings support the treatment’s increased contribution to reducing salt stress and their detrimental effects on bean plants.The findings of this study indicate that the use of these biostimulants, especially S. alba, P. guajava, and O. europaea leaf extracts can be considered as an unconventional, ecofriendly, and novel tool in the mitigation of salinity stress.
    Type of Medium: Online Resource
    ISSN: 1930-2126 , 1930-2126
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.15376/biores.18.3.
    DOI: 10.15376/biores
    DOI: 10.15376/biores.18.3.6142-6154
    Language: English
    Publisher: BioResources
    Publication Date: 2023
    detail.hit.zdb_id: 2238238-0
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  • 5
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    Online Resource
    Black Raisins Improved Experimentally Induced Iron Deficiency Anemia. Biochemical and Histological Evidence
    Sciencedomain International ; 2021
    In:  Journal of Pharmaceutical Research International ( 2021-07-01), p. 188-201
    Details
    In: Journal of Pharmaceutical Research International, Sciencedomain International, ( 2021-07-01), p. 188-201
    Abstract: Iron deficiency anemia is a challenging clinical problem with a profound impact on general health. Administration of iron-containing preparations were reported to be associated with many side effects. The current study aimed to evaluate black raisins’ therapeutic role against experimentally induced iron deficiency anemia in rats. Forty female rats were divided into 4 groups (n=10); control, anemia, anemia + iron, and anemia + raisins. Anemia was induced by bleeding and an iron-deficient diet for 4 weeks. Anemic rats were treated with ferric sulfate (200 mg/kg) or raisin extract (375 mg/kg) daily for 12 weeks. Complete blood count (CBC), blood films, body weight, splenic weight, and index were assessed. The spleens were processed and stained by hematoxylin and eosin (H & E) and immunohistochemically stained for CD3+ and CD68. Raisins contain a considerable amount of iron, vitamin B, phenolics, and flavonoid antioxidants. In raisins treated rats, CBC parameters displayed a significant increase compared to the anemic rats. Most of the RBCs in blood films showed normal shape, size, and central pallor. The spleen of raisins and iron-treated rats showed a marked increase in the area of white pulp. Their spleens also showed a significant increase in the CD3+ PALS area compared to anemic rats. Iron and raisins significantly decreased splenic CD68 macrophages. Consumption of black raisins could be considered an excellent natural source for flavonoids and iron to be used as an adjuvant supplement to iron for anemic patients with increased splenic T lymphocytes.
    Type of Medium: Online Resource
    ISSN: 2456-9119
    URL: Article
    DOI: 10.9734/jpri/2021/v33i34A31839
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2021
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  • 6
    Online Resource
    Online Resource
    Comparison between the effect of glibenclamide and captopril on experimentally induced diabetic nephropathy in rats
    Hindawi Limited ; 2013
    In:  Journal of the Renin-Angiotensin-Aldosterone System Vol. 14, No. 2 ( 2013-06), p. 103-115
    Details
    In: Journal of the Renin-Angiotensin-Aldosterone System, Hindawi Limited, Vol. 14, No. 2 ( 2013-06), p. 103-115
    Type of Medium: Online Resource
    ISSN: 1470-3203 , 1752-8976
    URL: Article
    DOI: 10.1177/1470320312460881
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2261873-9
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  • 7
    Online Resource
    Online Resource
    Production of a Yogurt Drink Enriched with Golden Berry (Physalispubescens L.) Juice and Its Therapeutic Effect on Hepatitis in Rats
    MDPI AG ; 2022
    In:  Fermentation Vol. 8, No. 3 ( 2022-03-06), p. 112-
    Details
    In: Fermentation, MDPI AG, Vol. 8, No. 3 ( 2022-03-06), p. 112-
    Abstract: Fermented dairy products have been associated with multiple health benefits. The present study aimed to produce a functional yogurt drink fortified with golden berry juice and assess its therapeutic effect on hepatitis rats. Thirty male albino rats were randomly divided into two major groups. The first group included the control (-) animals (six rats) and was fed a standard diet, whereas the second group included 24 rats that were fed a standard diet and injected with carbon tetrachloride (CCl4) for 2 weeks to trigger chronic damage of the liver (hepatitis); they were then divided into four groups (six rats/group): Group 2: hepatitis, fed on a standard diet as a positive control group; Group 3: received a basal diet with 5 mL of the yogurt drink; Group 4: received a basal diet with 5 mL of the yogurt drink fortified with 10% golden berry juice. Group 5: received a basal diet with 5 mL of the yogurt drink fortified with 20% golden berry juice. Various biological parameters were determined. Yogurt drink treatments were evaluated for their chemical, phytochemical, and sensory properties, as well as for their effects on hepatoprotective activity by determining various biochemical parameters. We found that the yogurt drinks containing golden berry juice exhibited no significant differences in fat, protein, and ash content compared with the control samples. Moreover, the yogurt drinks containing golden berry juice exhibited the highest content of total phenolic compounds, antioxidant activity, and organoleptic scores among all treatments. In addition, rats fed on a diet fortified with yogurt drinks containing golden berry juice for 8 weeks exhibited higher potential hepatoprotective effects compared with the liver injury control group. This improvement was partly observed in the group that received the yogurt drink containing golden berry juice. Therefore, we concluded that golden berry juice can be recommended as a natural additive in the manufacture of functional yogurt drinks, as it showed a potential hepatoprotective effect in rats with hepatitis.
    Type of Medium: Online Resource
    ISSN: 2311-5637
    URL: Article
    DOI: 10.3390/fermentation8030112
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2813985-9
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  • 8
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    Online Resource
    Arabic gum acacia improves diabetic peripheral neuropathy in rats: a biochemical and histopathological evidence
    Medip Academy ; 2018
    In:  International Journal of Basic & Clinical Pharmacology Vol. 7, No. 6 ( 2018-05-22), p. 1065-
    Details
    In: International Journal of Basic & Clinical Pharmacology, Medip Academy, Vol. 7, No. 6 ( 2018-05-22), p. 1065-
    Abstract: Background: Diabetic peripheral neuropathy (DPN) is a frequent complication of diabetes mellitus and unfortunately, its present therapeutic alternatives are exceptionally poor. Objectives of this study was to assess the antidiabetic, antioxidant and hypolipidemic action of Gum Arabic (GA) and its role in promoting the functional recovery from diabetic neuropathy developed in in an experimental model of diabetic neuropathy.Methods: Sixty adult male Sprague-Dawley rats were utilized and randomly assigned into six groups (n= 10); control, Arabic gum-treated, untreated diabetic, diabetic received metformin, diabetic received metformin and B12 vitamin and diabetic received metformin, B12 vitamin and AG. Locomotor activity and hyperalgesia were assed at the end of the study. Fasting and two hours post-prandial blood glucose, serum insulin levels, lipid Profile, oxidants/antioxidants parameters were assessed in the blood. Sciatic nerve was assessed histopathologically.Results: The locomotor activity of the untreated diabetic rats was significantly (p 〈 0.001) reduced compared to the control group while it was significantly increased in all treated groups. The lipid profile and Malondialdehyde were significantly improved in all treated groups. Levels of CAT, GSH, SOD, GPx were significantly decreased in untreated diabetic group compared to the control while they were significantly increased in all treated groups compared to the untreated diabetic group. Sciatic nerve fibers of untreated diabetic rats showed degenerated axons with dilated myelin sheaths and degenerated Schwann cells. The nerve had significantly fewer fiber compared to the control. These changes were alleviated in all the treated groups specifically that received metformin, vitamin B12 and GA.Conclusions: It could be concluded that Arabic gum had hypoglycemic, antioxidant and hypolipidemic activity and had a protective effect on diabetic neuropathy. Based on this it is recommended that human clinical trials are necessary to prove this therapeutic effect.
    Type of Medium: Online Resource
    ISSN: 2279-0780 , 2319-2003
    URL: Article
    DOI: 10.18203/2319-2003.ijbcp20181965
    Language: Unknown
    Publisher: Medip Academy
    Publication Date: 2018
    detail.hit.zdb_id: 2681376-2
    SSG: 15,3
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  • 9
    Online Resource
    Online Resource
    Potential Role of Thymoquinone in Imidaclopride Induced Testicular Toxicity in Male Albino Rats
    Egypts Presidential Specialized Council for Education and Scientific Research ; 2018
    In:  Benha Veterinary Medical Journal Vol. 34, No. 3 ( 2018-08-01), p. 64-82
    Details
    In: Benha Veterinary Medical Journal, Egypts Presidential Specialized Council for Education and Scientific Research, Vol. 34, No. 3 ( 2018-08-01), p. 64-82
    Type of Medium: Online Resource
    ISSN: 1110-6581
    URL: Article
    DOI: 10.21608/bvmj.2018.40917
    Language: English
    Publisher: Egypts Presidential Specialized Council for Education and Scientific Research
    Publication Date: 2018
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  • 10
    Online Resource
    Online Resource
    Green Synthesis of Zinc Oxide Nanoparticles (ZnO-NPs) Using Arthrospira platensis (Class: Cyanophyceae) and Evaluation of their Biomedical Activities
    MDPI AG ; 2021
    In:  Nanomaterials Vol. 11, No. 1 ( 2021-01-04), p. 95-
    Details
    In: Nanomaterials, MDPI AG, Vol. 11, No. 1 ( 2021-01-04), p. 95-
    Abstract: In this study, zinc oxide nanoparticles (ZnO-NPs) were successfully fabricated through the harnessing of metabolites present in the cell filtrate of a newly isolated and identified microalga Arthrospira platensis (Class: Cyanophyceae). The formed ZnO-NPs were characterized by UV–Vis spectroscopy, Fourier transform infrared (FT-IR), transmission electron microscopy (TEM), energy-dispersive spectroscopy (EDX), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). Data showed the efficacy of cyanobacterial metabolites in fabricating spherical, crystallographic ZnO-NPs with a size ≈30.0 to 55.0 nm at a wavelength of 370 nm. Moreover, FT-IR analysis showed varied absorption peaks related to nanoparticle formation. XPS analysis confirms the presence of Zn(II)O at different varied bending energies. Data analyses exhibit that the activities of biosynthesized ZnO-NPs were dose-dependent. Their application as an antimicrobial agent was examined and formed clear zones, 24.1 ± 0.3, 21.1 ± 0.06, 19.1 ± 0.3, 19.9 ± 0.1, and 21.6 ± 0.6 mm, at 200 ppm against Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans, respectively, and these activities were reduced as the NPs concentration decreased. The minimum inhibitory concentration (MIC) values were determined as 50 ppm for S. aureus, 25 ppm for P. aeruginosa, and 12.5 ppm for B. subtilis, E. coli, and C. albicans. More interestingly, ZnO-NPs exhibit high in vitro cytotoxic efficacy against cancerous (Caco-2) (IC50 = 9.95 ppm) as compared with normal (WI38) cell line (IC50 = 53.34 ppm).
    Type of Medium: Online Resource
    ISSN: 2079-4991
    URL: Article
    DOI: 10.3390/nano11010095
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2662255-5
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