In:
Chemistry – A European Journal, Wiley, Vol. 15, No. 14 ( 2009-03-23), p. 3457-3473
Abstract:
Jackpot: Two for one! Concise and highly convergent syntheses of the immunosuppressive agent FR252921 and the related antimicrobial natural product pseudotrienic acid B were achieved from one common intermediate by using optically active titanium complexes to control the configuration of the stereogenic centers, a highly stereo‐ and regioselective cross‐metathesis to generate the triene moieties, and a Stille cross‐coupling to install the dienic units. magnified image Concise and highly convergent syntheses of the immunosuppressive agent FR252921 and the related antimicrobial natural product pseudotrienic acid B were achieved from a common intermediate by using optically active titanium complexes to control the configuration of the stereogenic centers, a highly stereo‐ and regioselective cross‐metathesis to generate the triene moieties, and a Stille cross‐coupling to install the dienic units.
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.200802649
Language:
English
Publisher:
Wiley
Publication Date:
2009
detail.hit.zdb_id:
1478547-X
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