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  • 1
    Online Resource
    Online Resource
    Data_Sheet_1.PDF
    Frontiers Media SA ; 2020
    In:  Frontiers in Genetics Vol. 11 ( 2020-12-18)
    Details
    In: Frontiers in Genetics, Frontiers Media SA, Vol. 11 ( 2020-12-18)
    Abstract: Head and neck paragangliomas (HNPGLs) are rare neuroendocrine tumors that have a high degree of heritability and are predominantly associated with mutations in ten genes, such as SDHx, SDHAF2, VHL, RET, NF1, TMEM127, MAX, FH, MEN2 , and SLC25A11 . Elucidating the mutation prevalence is crucial for the development of genetic testing. In this study, we identified pathogenic/likely pathogenic variants in the main susceptibility genes in 102 Russian patients with HNPGLs (82 carotid and 23 vagal paragangliomas) using whole exome sequencing. Pathogenic/likely pathogenic variants were detected in 43% (44/102) of patients. We identified the following variant distribution of the tested genes: SDHA (1%), SDHB (10%), SDHC (5%), SDHD (24.5%), and RET (5%). SDHD variants were observed in the majority of the patients with bilateral/multiple paragangliomas. Thus, among Russian patients with HNPGLs the most frequently mutated gene was SDHD followed by SDHB, SDHC, RET , and SDHA .
    Type of Medium: Online Resource
    ISSN: 1664-8021
    URL: Article
    URL: Article
    DOI: 10.3389/fgene.2020.614908
    DOI: 10.3389/fgene.2020.614908.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2606823-0
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  • 2
    Online Resource
    Online Resource
    Leukocytes count and profile during early postnatal ontogenesis in domestic cats: Effect of litter size and multiple paternity
    Wiley ; 2021
    In:  Journal of Experimental Zoology Part A: Ecological and Integrative Physiology Vol. 335, No. 8 ( 2021-10), p. 637-648
    Details
    In: Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Wiley, Vol. 335, No. 8 ( 2021-10), p. 637-648
    Abstract: Number of leukocytes and their individual types changed in domestic kittens before the age of 3 months, when values reached adult level. Litter size and number of fathers in litter affected the number of leukocytes and neutrophils in kittens.
    Type of Medium: Online Resource
    ISSN: 2471-5638 , 2471-5646
    URL: Issue
    URL: Article
    DOI: 10.1002/jez.v335.8
    DOI: 10.1002/jez.2508
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1474896-4
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  • 3
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    Body mass of Procarpa gutturosa (Bovidae) calves: influence of climatic conditions and occurrence of pathogens in the group of the Daursky State Nature Reserve (Russia)
    Fund for Support and Development of Protected Areas ; 2022
    In:  Nature Conservation Research Vol. 7, No. 4 ( 2022)
    Details
    In: Nature Conservation Research, Fund for Support and Development of Protected Areas, Vol. 7, No. 4 ( 2022)
    Abstract: Procapra gutturosa (hereinafter – Mongolian gazelle) is one of the last large migratory mammal species in Asia, which population has declined considerably over the past century due to various anthropogenic factors. In Russia, the Mongolian gazelle inhabits the north of its natural range, which supposes suboptimal conditions for this species, and it is listed in the Red Data Book of the Russian Federation. The physiological status of its calves was studied in the Daursky State Nature Reserve in 2015–2021 by assessing their body mass and the presence of antibodies to several pathogens. It was found that the body mass of Mongolian gazelle calves averaged from 2.85 kg to 6.14 kg and varied depending on such factors as sex, age and year of data collection. It was also related to climatic conditions, especially during the last third of pregnancy. In addition, Mongolian gazelle individuals were identified, which are seropositive to foot-and-mouth disease and peste des petits ruminants, but not to pasteurellosis and brucellosis. The number of positive reactions to the pathogens varied from year to year. So, the highest number of seropositive individuals was detected in 2018, representing 63.3%. Being still connected with the main range, the Mongolian gazelle group in Russia (surroundings of the Daursky State Nature Reserve) is gradually increasing. The study of animals’ physiological condition makes it possible to predict changes in the status of this ungulate group.
    Type of Medium: Online Resource
    ISSN: 2500-008X
    URL: Article
    DOI: 10.24189/ncr.2022.038
    Language: Unknown
    Publisher: Fund for Support and Development of Protected Areas
    Publication Date: 2022
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  • 4
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    Online Resource
    Effect of population density on number of leukocytes in domestic cats
    Fund for Support and Development of Protected Areas ; 2020
    In:  Nature Conservation Research Vol. 5, No. 2 ( 2020)
    Details
    In: Nature Conservation Research, Fund for Support and Development of Protected Areas, Vol. 5, No. 2 ( 2020)
    Type of Medium: Online Resource
    ISSN: 2500-008X
    URL: Article
    DOI: 10.24189/ncr.2020.021
    Language: Unknown
    Publisher: Fund for Support and Development of Protected Areas
    Publication Date: 2020
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  • 5
    Online Resource
    Online Resource
    Application of Felid Hair for Non-Invasive Tracking of Animal Reproductive Status and Adrenal Activity
    MDPI AG ; 2022
    In:  Animals Vol. 12, No. 20 ( 2022-10-16), p. 2792-
    Details
    In: Animals, MDPI AG, Vol. 12, No. 20 ( 2022-10-16), p. 2792-
    Abstract: Hair can be a useful matrix to examine the hormonal status of an animal, although it is difficult to correlate the results to a specific time point. The aim of this study was to evaluate seasonal changes in cortisol and testosterone levels in the hair of four feline species (lynx, Lynx lynx, n = 8; Amur wildcat, Prionailurus bengalensis euptilurus, n = 8; caracal, Caracal caracal, n = 6 and domestic cat, Felis catus, n = 17) with different breeding strategies. Animals of both sexes were sampled over the year, once per season (every three months), and the concentrations of hair testosterone and cortisol were measured by EIA. Both hormones showed annual dynamic changes, which coincided with the reproductive seasonality of the studied species. Sexual differences in testosterone level were found only during the mating season (spring for lynx and Amur wildcats, spring–summer for domestic cats), when testosterone levels were higher in males than in females. Cortisol levels were higher in males than in females in domestic cats and Amur wildcat, but also only during the mating season. Seasonal increases in testosterone were observed in three seasonal breeders (lynx, Amur wildcat and domestic cat) but not in caracal, which had high testosterone levels over the whole year. In lynx and Amur wildcat, it decreased sharply in the summer. Cortisol levels increased during the mating period in domestic cat males and lynx of both sexes; in caracal, an increase in cortisol was related to the transfer of animals to smaller winter cages. Measurements of steroids in hair can provide a reliable method for evaluating the reproductive status and the activity of the hypothalamus–pituitary–adrenal axis in several felid species.
    Type of Medium: Online Resource
    ISSN: 2076-2615
    URL: Article
    DOI: 10.3390/ani12202792
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2606558-7
    SSG: 23
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  • 6
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    Online Resource
    The First Case of Cytauxzoon spp. in Russia: The Parasite Conquers Eurasia
    MDPI AG ; 2022
    In:  Animals Vol. 12, No. 5 ( 2022-02-27), p. 593-
    Details
    In: Animals, MDPI AG, Vol. 12, No. 5 ( 2022-02-27), p. 593-
    Abstract: Over the last two decades, Cytauxzoon spp. has been conquering Eurasia, although this fact has only been brought to light through recent more intensive research after the discovery of C. manul in Pallas’ cat. In Europe, Cytauxzoon was detected mainly in southern countries and later in central Europe. This pathogen has now been found in Russia for the first time (50 km from Moscow), this being the most northern sighting in Eurasia. A captive serval (Leptailurus serval) was found to be infected. Hematological analysis showed a crucial decrease in the number of leukocytes and erythrocytes, as well as in hemoglobin concentration. Genetic analysis confirmed the presence of Cytauxzoon spp. in serval blood at the beginning of the disease period. The identical pathogen was found in one bobcat at the same breeding center. Two other haplotypes of Cytauxzoon spp. were obtained from domestic cats at the same location, identical to the samples from Italy. One new haplotype, which was sequenced for the first time, was found in 7/7 investigated Amur wildcats (100%). The high occurrence and diversity of these pathogens suggest that they are present in free-ranging domestic cats and wild felids in Russia, and may be considered a potential threat to the endangered species. Current research shows that the genetic diversity of this pathogen may be even higher than it was suggested previously. Further genetic research is necessary to describe the diversity and phylogeny of this pathogen in Eurasia.
    Type of Medium: Online Resource
    ISSN: 2076-2615
    URL: Article
    DOI: 10.3390/ani12050593
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2606558-7
    SSG: 23
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  • 7
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    Online Resource
    Meows of captive feral domestic cats (Felis silvestris catus) in the mating season: acoustic correlates of caller identity and sex
    Brill ; 2023
    In:  Behaviour ( 2023-09-29), p. 1-20
    Details
    In: Behaviour, Brill, ( 2023-09-29), p. 1-20
    Abstract: This study investigates the frequency, temporal and power parameters in 11 (5 males, 6 females) captive feral domestic cats Felis silvestris catus , vocalising in their individual outdoor enclosures during the mating season. Discriminant function analysis (DFA) classified the meows to correct callers with 79.2% accuracy, which exceeded the chance level of 22.9 ± 2.8%, calculated with permutation test. Male meows were lower-frequency, with the maximum fundamental frequency of 0.37 ± 0.05 kHz vs 0.61 ± 0.16 kHz in females. Sex differences in the maximum, beginning and end fundamental frequencies varied from 32 to 39%, depending on acoustic parameter. The DFA classified the meows to correct sex with accuracy of 88.0%, which exceeded the chance level of 58.2 ± 3.1%. We discuss that the meows encode information about individual identity and sex and that acoustic differences in frequency parameters of the meows exceed sexual dimorphism of body size in domestic cat.
    Type of Medium: Online Resource
    ISSN: 0005-7959 , 1568-539X
    URL: Article
    DOI: 10.1163/1568539X-bja10239
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Brill
    Publication Date: 2023
    detail.hit.zdb_id: 2007939-4
    SSG: 12
    SSG: 5,2
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  • 8
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    Online Resource
    Stressed by Maternity: Changes of Cortisol Level in Lactating Domestic Cats
    MDPI AG ; 2020
    In:  Animals Vol. 10, No. 5 ( 2020-05-22), p. 903-
    Details
    In: Animals, MDPI AG, Vol. 10, No. 5 ( 2020-05-22), p. 903-
    Abstract: Lactation is the most energetically expensive component of maternal care in mammals. Increased reproductive investment can lead to physiological stress for the mothers, based on the exhaustion of energy resources and increase in glucocorticoids level. This study aimed to estimate the changes in cortisol concentrations during lactation in domestic cats and compared the differences among litter sizes. Eleven females gave birth to 27 litters, which were divided in two groups—small (1–3 kittens) and large (4–7 kittens) litters. Blood samples were collected from each female before mating, after parturition, at 4 and 8 weeks of lactation. We showed that the cortisol level in females changed significantly during lactation—the highest concentrations were observed at the peak of lactation at 4 weeks. Cortisol levels varied significantly among females but did not depend on their maternal experience. We also revealed that there were no differences in cortisol levels between females with small and large litters, but at 4 weeks of lactation, the hormone concentrations were higher in females with small litters. It is likely that these females initially invested less in reproduction, giving birth to fewer offspring.
    Type of Medium: Online Resource
    ISSN: 2076-2615
    URL: Article
    DOI: 10.3390/ani10050903
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2606558-7
    SSG: 23
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  • 9
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    Online Resource
    The method matters: The effect of handling time on cortisol level and blood parameters in wild cats
    Wiley ; 2018
    In:  Journal of Experimental Zoology Part A: Ecological and Integrative Physiology Vol. 329, No. 3 ( 2018-03), p. 112-119
    Details
    In: Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Wiley, Vol. 329, No. 3 ( 2018-03), p. 112-119
    Abstract: Blood analysis has recently become a popular tool to assess the welfare of the wild cats. However, the estimates of blood parameters may depend on the sampling method. We have tested (1) if the sampling procedure influences blood parameters and (2) what parameters are the most efficient in assessing the physiological status in wild cat species. We assessed the effect of handling time on red blood cells (RBC) and white blood cells (WBC) counts, the ratio of neutrophils to lymphocytes (N/L ratio), and serum cortisol level within 1 hr after the capture of the animal in six far‐east wild cats ( Prionailurus bengalensis euptilura ). Also, we analyzed literature data in 17 cat species to assess the effect of place of study, type of immobilization, and handling time on WBC count and N/L ratio. Serum cortisol level varied significantly with the handling time. RBC and WBC counts were strongly affected by the handling time. N/L ratio was very robust and did not depend on the handling time. However, the analysis of literature data has shown that the prolonged handling time (over 1 hr) and the type of immobilization significantly influence the N/L ratio, whereas the WBC count does not depend on any of considered factors. We conclude that while most blood parameters of cats are affected by routine handling time, the N/L ratio does not vary if the samples are collected within 1 hr after the capture of the animal. All other tested parameters should be treated with caution.
    Type of Medium: Online Resource
    ISSN: 2471-5638 , 2471-5646
    URL: Issue
    URL: Article
    DOI: 10.1002/jez.v329.3
    DOI: 10.1002/jez.2191
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1474896-4
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  • 10
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    Online Resource
    A clinical case of the use of a new selective μ1-opioid analgesic Tafalgin in the treatment of chronic cancer pain
    Consilium Medicum ; 2022
    In:  Journal of Modern Oncology Vol. 24, No. 3 ( 2022-11-25), p. 313-318
    Details
    In: Journal of Modern Oncology, Consilium Medicum, Vol. 24, No. 3 ( 2022-11-25), p. 313-318
    Abstract: In the Russian Federation, tetrapeptide tyrosyl-D-arginyl-phenylalanyl-glycine amide (Tafalgin), a novel analgesic, selective agonist of 1-opioid receptors, was developed and approved in 2022. The article presents the first experience of the successful use of Tafalgin in treating chronic pain in a cancer patient with poor tolerance to traditional opioids (tramadol, tapentadol, morphine). At baseline, pain severity, according to the Neurological Rating Scale (NRS), was 57 points at rest and up to 9 points in motion out of the maximum 10. The combination of 400 mg/day of tramadol with gabapentin and a non-steroidal anti-inflammatory drug was ineffective; 400 mg/day of tapentadol in combination with gabapentin and a non-steroidal anti-inflammatory drug also was ineffective. Morphine tablets 60 mg/day were effective (NRS score of 23), but unrelenting nausea and vomiting were unmanageable and significantly reduced quality of life. Reducing the dose of oral morphine to 20 mg/day mitigated adverse events but reduced the effectiveness of pain relief (resting NRS score of 4 points). Tafalgin 4 mg subcutaneously BID, then TID reduced the pain severity to an average daily NRS score of 1.22 over the first 3 days of treatment with no adverse events. Sleep, appetite, and physical activity improved. The patient received Tafalgin for 84 days, and she gained 5 kg due to improved nutrition during that time. The drug is comparable in efficacy to morphine and is associated with fewer adverse events. A limitation to widespread use is the availability of a formulation for subcutaneous injection only.
    Type of Medium: Online Resource
    ISSN: 1815-1442 , 1815-1434
    URL: Article
    DOI: 10.26442/18151434.2022.3.201913
    Language: Unknown
    Publisher: Consilium Medicum
    Publication Date: 2022
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