In:
Zeitschrift für Naturforschung B, Walter de Gruyter GmbH, Vol. 62, No. 4 ( 2007-4-1), p. 523-528
Abstract:
A series of 4-nitroimidazole derivatives bearing substituted piperazines (5, 8, 9, 12, 14, 16, 17, and 19 - 21) were synthesized with the aim to develop new non-nucleoside reverse transcriptase inhibitors (NNRTIs). The newly synthesized compounds were assayed against HIV-1 and HIV-2 in MT-4 cells. All compounds are inactive, except compound 21 which showed inhibition of HIV-1 with EC 50 0.20 μg/mL, and therapeutic indexes (SI) of 12.
Type of Medium:
Online Resource
ISSN:
1865-7117
,
0932-0776
DOI:
10.1515/znb-2007-0406
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2007
detail.hit.zdb_id:
2078109-X
detail.hit.zdb_id:
124635-5
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