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  • 1
    Online Resource
    Online Resource
    Regional variation in characteristics of patients with decompensated cirrhosis admitted to hospitals in the UK
    Elsevier BV ; 2023
    In:  The Lancet Gastroenterology & Hepatology Vol. 8, No. 7 ( 2023-07), p. 604-606
    Details
    In: The Lancet Gastroenterology & Hepatology, Elsevier BV, Vol. 8, No. 7 ( 2023-07), p. 604-606
    Type of Medium: Online Resource
    ISSN: 2468-1253
    URL: Article
    DOI: 10.1016/S2468-1253(23)00114-0
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
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  • 2
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    Defining characteristics and outcomes for patients with non-alcoholic fatty liver disease admitted to hospital with decompensated cirrhosis
    Elsevier BV ; 2023
    In:  Journal of Hepatology Vol. 79, No. 4 ( 2023-10), p. e165-e167
    Details
    In: Journal of Hepatology, Elsevier BV, Vol. 79, No. 4 ( 2023-10), p. e165-e167
    Type of Medium: Online Resource
    ISSN: 0168-8278
    URL: Article
    DOI: 10.1016/j.jhep.2023.05.035
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2027112-8
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  • 3
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    Awareness of human papillomavirus and acceptability of the vaccine among women in Palestine: is it time for policy adjustment?
    Springer Science and Business Media LLC ; 2022
    In:  BMC Women's Health Vol. 22, No. 1 ( 2022-08-19)
    Details
    In: BMC Women's Health, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-08-19)
    Abstract: Progress has been made in the reduction of morbidity and mortality of cervical cancer by the implementation of human papillomavirus (HPV) vaccination programs. This study aimed to assess the awareness of Palestinian women about HPV as well as their knowledge and acceptability of the HPV vaccine and to examine the factors associated with good awareness. Methods This was a national cross-sectional study. Adult women were recruited from hospitals, primary healthcare centers, and public spaces in 11 Palestinian governorates using convenience sampling. A structured questionnaire was used for data collection. For each correctly answered question, one point was given. The total score was calculated and categorized into poor (0–10) and good awareness (11–21). Results The questionnaire was completed by 7223 women out of 8086 who were approached (response rate = 89.3%). A total of 7058 questionnaires were included in the final analysis; 4403 from the West Bank and Jerusalem (WBJ) and 2655 from the Gaza Strip. Women recruited from the Gaza Strip were younger, getting lower monthly incomes, and with fewer chronic diseases than women recruited from the WBJ. Only 33 women (0.5%) displayed good awareness of HPV and its vaccine with 0.7% of women from WBJ and only 0.2% of women from the Gaza Strip. Completing post-secondary education, being employed or a student, and having a higher monthly income were associated with an increase in the likelihood of having good awareness. Among women who had heard of HPV (n = 571, 8.1%), only 46 women (8.1%) reported familiarity with its vaccine. Women from the WBJ were more likely than women from the Gaza Strip to have heard about the HPV vaccine (0.9% vs. 0.2%). Most women agreed to receive the HPV vaccine themselves or for their daughters if it was given without cost or with a co-payment. No differences were found in the likelihood of agreeing to receive the HPV vaccine among women in the WBJ versus the Gaza Strip. Conclusion The overall awareness of HPV and its vaccine was extremely low. Inclusion of the HPV vaccine in the national immunization program could change this, especially as the HPV vaccine appeared to be acceptable.
    Type of Medium: Online Resource
    ISSN: 1472-6874
    URL: Article
    DOI: 10.1186/s12905-022-01930-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2050444-5
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  • 4
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    Novel swine model of colonic diverticulosis
    American Physiological Society ; 2019
    In:  American Journal of Physiology-Gastrointestinal and Liver Physiology Vol. 317, No. 1 ( 2019-07-01), p. G51-G56
    Details
    In: American Journal of Physiology-Gastrointestinal and Liver Physiology, American Physiological Society, Vol. 317, No. 1 ( 2019-07-01), p. G51-G56
    Abstract: The pathophysiology of colonic diverticulosis has not been completely understood. The development of appropriate animal models is essential to study diverticular disease. To date, no large animal models are available for this disease condition. The objective of this study was to develop a swine model by damaging the colon wall, combined with or without a low-fiber diet to mimic the pathogenesis of diverticulosis. To create a weakness on the colon wall, collagenase was applied in vivo to degrade the collagen in the colon wall. Three groups of Yucatan minipigs were included. Group 1 ( n = 12) underwent collagenase injection (CI) with a low-fiber diet for 6 mo, group 2 ( n = 8) underwent CI alone with a standard swine diet for 6 mo, and group 3 ( n = 12) received a low-fiber diet alone for 6 mo. We found that diverticulosis occurred in 91.7% (11 of 12) of pigs in the CI + diet group and 100% (8 of 8) in CI-alone group. Moreover, around 30–75% of colon CI spots for each pig developed diverticular lesions. Diet alone for 6 mo did not induce diverticulosis. The endoscopic and histological examinations revealed the formation of multiple wide-mouthed diverticular lesions along the descending colon. Our results provide convincing evidence of the high efficacy of the reduced colon wall strength caused by CI in the development of a swine model of diverticulosis. Low-fiber diet consumption for 6 mo had no influence on the generation time or incidence rate of diverticulosis. In this model, digestion of the collagen in the colonic wall is sufficient to cause diverticulosis. NEW & NOTEWORTHY Effective large animal models of diverticulosis are currently lacking for the study of diverticular disease. This study marks the first time that a swine model of diverticulosis was developed by damaging colon wall structure, combined with or without a low-fiber diet. We found that a defect of colon wall could result in colon diverticular lesions within 6 mo in swine. This animal model mimicking the pathological process of diverticulosis is of great clinical value.
    Type of Medium: Online Resource
    ISSN: 0193-1857 , 1522-1547
    URL: Article
    DOI: 10.1152/ajpgi.00408.2018
    Language: English
    Publisher: American Physiological Society
    Publication Date: 2019
    detail.hit.zdb_id: 1477329-6
    SSG: 12
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  • 5
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    Localized aggressive periodontitis immune response to healthy and diseased subgingival plaque
    Wiley ; 2016
    In:  Journal of Clinical Periodontology Vol. 43, No. 9 ( 2016-09), p. 746-753
    Details
    In: Journal of Clinical Periodontology, Wiley, Vol. 43, No. 9 ( 2016-09), p. 746-753
    Abstract: The objective of this case–control study was to compare the inflammatory response of peripheral blood from localized aggressive periodontitis ( LAP ) patients when stimulated with healthy or diseased plaque samples. Materials and Methods Whole blood and subgingival plaque samples were collected from 13 LAP subjects, 14 siblings of LAP subjects and six periodontally healthy individuals. Whole blood was stimulated for 24 h with plaque samples generated from healthy or diseased sites. The levels of 14 cyto/chemokines were detected using multiplex technology. Results Localized aggressive periodontitis‐derived cultures displayed higher levels of G‐CSF , INF γ , IL 10, IL 12p40, IL 1 β , IL ‐6, IL ‐8, MCP ‐1, MIP ‐1 α , and TNF α , than control cultures regardless of stimulus used. Whole blood from healthy siblings displayed higher levels of IL ‐6 compared to control subjects, but lower levels than those observed in cultures from LAP participants. Conclusions This study suggests that although bacteria is an important factor in eliciting the hyper‐inflammatory response observed in LAP patients, the predisposition of host's response to bacterial presence may play a more significant role than the components of the stimulatory plaque.
    Type of Medium: Online Resource
    ISSN: 0303-6979 , 1600-051X
    URL: Issue
    URL: Article
    DOI: 10.1111/jcpe.2016.43.issue-9
    DOI: 10.1111/jcpe.12560
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2026349-1
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  • 6
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    Knowledge of cervical cancer risk factors among Palestinian women: a national cross-sectional study
    Springer Science and Business Media LLC ; 2021
    In:  BMC Women's Health Vol. 21, No. 1 ( 2021-12)
    Details
    In: BMC Women's Health, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)
    Abstract: High awareness of cervical cancer (CC) risk factors is important to decrease the morbidity and mortality associated with CC. This study aimed to assess the knowledge level of Palestinian women about CC risk factors and to determine the factors associated with good knowledge. Methods This was a national cross-sectional study. Adult women from hospitals, primary healthcare centers, and public spaces of 11 governorates in Palestine were recruited using a stratified convenience sampling. A translated-into-Arabic version of the validated CC awareness measure (CeCAM) was used to assess the knowledge about the 11 CC risk factors. For each correctly identified risk factor, the participant was given one point. The total score was calculated and was categorized into three categories: poor knowledge (0–3), fair knowledge (4–7), and good knowledge (8–11). Results A total of 7223 participants completed the Arabic CeCAM (response rate = 89.3%) and 7058 questionnaires were included in the final analysis: 2655 from the Gaza Strip and 4403 from the West Bank and Jerusalem. Participants recruited from the Gaza Strip were younger, getting lower monthly incomes, and with less chronic diseases than participants recruited from the West Bank and Jerusalem. The most frequently identified risk factor was ‘having a weakened immune system’ (n = 5458, 77.3%) followed by ‘infection with a sexually transmitted infection’ (n = 5388, 76.3%). The least identified risk factor was ‘having many children’ (n = 1597, 22.6%). Only 1670 women (23.7%) had good knowledge of CC risk factors. Women living in the Gaza Strip were more likely than women living in the West Bank and Jerusalem to have good knowledge (25.2% vs 22.7%). Completing a secondary or diploma degree, being employed, and having a monthly income of ≥ 1450 NIS (around $450) were all associated with lower likelihood of having good knowledge of CC risk factors. Conversely, knowing someone with cancer was associated with higher likelihood of having good knowledge. Conclusion The overall awareness of CC risk factors was low. There is a substantial need to establish educational programs to promote Palestinian women’s awareness of CC.
    Type of Medium: Online Resource
    ISSN: 1472-6874
    URL: Article
    DOI: 10.1186/s12905-021-01510-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2050444-5
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  • 7
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    Association of college entrance exam with changes in some lifestyle factors among adolescents
    Emerald ; 2013
    In:  Nutrition & Food Science Vol. 43, No. 6 ( 2013-10-28), p. 573-581
    Details
    In: Nutrition & Food Science, Emerald, Vol. 43, No. 6 ( 2013-10-28), p. 573-581
    Abstract: – The study was conducted to investigate the impact of competitive entrance exams on some lifestyle factors that may lead to body weight gain. The paper aims to discuss these issues. Design/methodology/approach – A cross-sectional study was conducted on high school students ( n =660), aged 16-20 years, to assess changes in body weight and fat percentage, dietary habits and physical activity practicing before and after the examination. Findings – During the examination period, both males and females experienced weight gain, but the mean change of body weight for males was higher compared to the mean change of body weight observed in females (3.6 vs 0.6 kg). Body fat percentage increased in males and females in approximately 2 and 0.3 percent, respectively. In addition, males were found to skip breakfast ( p =0.003) during the examination period as compared to females ( p =1.00). Both males and females reported an increased consumption of milk ( p =0.007 and 0.001), junk food ( p =0.0001 and 0.001), caffeinated beverages ( p 〈 0.001) and carbonated drinks ( p =0.001). A significant proportion from each gender reported that they quit recreational physical activity during the examination period ( p =0.0001). Originality/value – Several studies were conducted to investigate the impact of academic exams on stress among this vulnerable group; however, the relationship of body weight and obesity is still lacking in this population. Therefore, this study aims to investigate impact of competitive entrance exams on some lifestyle behaviours that may lead to body weight gain.
    Type of Medium: Online Resource
    ISSN: 0034-6659
    URL: Article
    DOI: 10.1108/NFS-09-2012-0100
    Language: English
    Publisher: Emerald
    Publication Date: 2013
    detail.hit.zdb_id: 2016217-0
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  • 8
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    Knowledge of Palestinian women about cervical cancer warning signs: a national cross- sectional study
    Springer Science and Business Media LLC ; 2021
    In:  BMC Public Health Vol. 21, No. 1 ( 2021-12)
    Details
    In: BMC Public Health, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)
    Abstract: Timely presentation and diagnosis of cervical cancer (CC) are crucial to decrease its mortality especially in low- and middle-income countries like Palestine. This study aimed to evaluate the knowledge of Palestinian women about CC warning signs and determine the factors associated with good knowledge. Methods This was a national cross-sectional study conducted between July 2019 and March 2020 in Palestine. Stratified convenience sampling was used to recruit adult women from hospitals, primary healthcare centers, and public spaces of 11 governorates. A translated-into-Arabic version of the validated CC awareness measure (CeCAM) was used to assess women’s knowledge of 12 CC warning signs. Results Of 8086 approached, 7223 participants completed the CeCAM (response rate = 89.3%). A total of 7058 questionnaires were included in the analysis: 2655 from the Gaza Strip and 4403 from the West Bank and Jerusalem (WBJ). The median age [interquartile range] for all participants was 34.0 [24.0, 42.0] years. Participants recruited from the WBJ were older, getting higher monthly income, and having more chronic diseases than those recruited from the Gaza Strip. The most frequently identified warning sign was ‘vaginal bleeding after menopause’ ( n  = 5028, 71.2%) followed by ‘extreme generalized fatigue’ ( n  = 4601, 65.2%) and ‘unexplained weight loss’ ( n  = 4578, 64.9%). Only 1934 participants (27.4%) demonstrated good knowledge of CC warning signs. Participants from the Gaza Strip were slightly more likely than participants from the WBJ to have a good level of knowledge. Factors associated with having good knowledge included having a bachelor or postgraduate degree, being married, divorced, or widowed as well as knowing someone with cancer. Conclusion The overall awareness of CC warning signs was low. Educational interventions are needed to increase Palestinian women’s awareness of CC warning signs.
    Type of Medium: Online Resource
    ISSN: 1471-2458
    URL: Article
    DOI: 10.1186/s12889-021-11792-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2041338-5
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